Wyniki wyszukiwania

1

Inhibition in learning - induced cortical plasticity

100%

Kossut M.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 5

2

Modifications of the single cortical vibrissal column

100%

Kossut M.

Acta Neurobiologiae Experimentalis

|

1988

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tom 48

|

nr 2-3

3

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Engram

100%

Kossut M.

Wszechświat

|

2016

|

tom 117

|

nr 01-03

4

Contribution of the GABAergic system to cortical plasticity

100%

Kossut M.

Acta Neurobiologiae Experimentalis

|

2015

|

tom 75

|

nr Supl.

Experience-induced plastic changes in the cerebral cortex are accompanied by alterationsin excitatory and inhibitory transmission. Increased excitatory drive, necessary for plasticity, precedes the occurrence of plastic change, while decreased inhibitory signaling often facilitates plasticity. However, an increase of inhibitory interactions was noted in some instances of experience-dependent changes. We found upregulation of the number of inhibitory markers in the barrel cortex of mice after classical conditioning engaging vibrissae, observed concurrently with enlargement of the cortical representational area of the row of vibrissae receiving conditioned stimulus (CS). We also observed that an increase of GABA level accompanied the conditioning. Moreover, Npas4, a transcription factor important for structural and functional neuronal plasticity and identified as an element of the program controlling inhibitory synapse development, was affected by conditioning. With real-time PCR on laser-dissected individual rows of barrels we found that Npas4 mRNA level was upregulated following conditioning. In order to find whether unaltered GABAergic signaling is necessary for learning-dependent rewiring in the murine barrel cortex, we locally decreased GABA production in the barrel cortex or reduced transmission through GABAA receptors at the time of the conditioning. Both treatments prevented learninginduced enlargement of the conditioned vibrissae representation. At the behavioral level, consolidation of the conditioned response (cessation of head movements in response to CS) was impaired. These results show that appropriate functioning of the GABAergic system is required for both manifestation of functional cortical representation plasticity and for the development of a conditioned response.

5

Fear learning and the barrel cortex

100%

Kossut M.

Acta Neurobiologiae Experimentalis

|

2017

|

tom 77

|

nr Suppl.1

The sensory system linking mystacial vibrissae to barrels in somatosensory cortex is an object of many studies concerning brain plasticity. Sensory denervation, sensory deprivation and learning paradigms have been used to explore mechanisms of use-dependent plastic changes of cortical physiology, anatomy, neurochemistry and microstructure. The lecture will describe experiments examining changes in functioning of the barrel cortex evoked by classical conditioning in which stimulation of vibrissae was used as CS and tail shock as UCS. Plastic modification of the barrel cortex activation pattern following fear learning was revealed by 2-deoxyglucose autoradiography, showing expanded cortical representation of vibrissae to which CS was applied. This effect was NMDA receptor‑dependent, and modified inhibitory and xcitatory neurotransmission within the barrels. Changes in electrophysiological properties of neurons were observed, together with rapid inhibitory synaptogenesis. Activity dependent alterations were found in the ultrastructure of both inhibitory and excitatory synapses. The role of GABAergic transmission in learning-dependent plasticity of the barrel cortex will be discussed

6

Plastycznosc w rozwoju ukladu nerwowego

100%

Kossut M.

Kosmos

|

1993

|

tom 42

|

nr 2

213-236

7

Neuromodulacja - magnetyczna i elektryczna ingerencja w pracę mózgu

100%

Kossut M.

Wszechświat

|

2020

|

tom 121

|

nr 01-03

8

Neurotransmitter receptors and the plasticity of the brain cortex

100%

Kossut M.

Cellular and Molecular Biology Letters

|

2002

|

tom 07

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nr Suppl.

9

The impact of sensory experience on cortical function

88%

Kossut M.

Acta Neurobiologiae Experimentalis

|

1997

|

tom 57

|

nr 5

10

Neuroplastycznosc i neurorehabilitacja

88%

Kossut M.

Wszechświat

|

2010

|

tom 111

|

nr 01-03

5-7

11

Glutamatergic and GABA-ergic involvement in learning-dependent plasticity of sensory cortex

88%

Kossut M.

Acta Neurobiologiae Experimentalis

|

2001

|

tom 61

|

nr 3

12

Different forms of plasticity in the barrel cortex

75%

Kossut M.

Acta Neurobiologiae Experimentalis

|

1992

|

tom 52

|

nr 3

13

Increase of gaba receptor biding activity after short lasting monocular deprivation in kittens

63%

Skangiel-Kramska J., Kossut M.

Acta Neurobiologiae Experimentalis

|

1984

|

tom 44

14

Short-term sensory learning does not alter Parvalbumin neurons in the barrel cortex of adult mice

63%

Siucinska E., Kossut M.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 3

15

The learning brain - activation during classical conditioning

63%

Kossut M., Cybulska A.

Acta Neurobiologiae Experimentalis

|

2009

|

tom 69

|

nr 3

The neural bases of appetitive and aversive conditioning are different, and at various stages of learning may engage distinct cortical and subcortical networks. Using [14C]2-deoxyglucose (2-DG) autoradiography we examined brain activation in mice during classical conditioning involving stimulation of whiskers on one side of the muzzle paired with an aversive or appetitive UCS. Both variants result in modifi cation of cortical representations of vibrissae activated during the conditioning. Analysis of autoradiograms revealed that the nucleus basalis of Meynert (NBM) and ventral pallidum showed stronger labeling during appetitive training while the lateral hypothalamus (LH) and basolateral amygdala (BLA) were activated only by aversive learning. Apart from that, classicalconditioning with appetitive or aversive UCS increased 2-DG uptake in a similar set of brain structures – the posterior parietal cortex (PPC), cingulate (CG) and retrosplenial gyrus (RET), caudate nucleus (CPU) and nucleus accumbens (NA). Formation of sensory association, compared to pseudoconditioning, induces more activity in the subcortical sensory processing pathway (ventral postero-medial and posterior nuclei of the thalamus) but not in the barrel cortex. Also, conditioning contrasted with pseudoconditioning increases activity in structures important for cognitive and attentional functions (PPC, NA, CG, RET, CPU), which might provide the enhancing input necessary for memory trace formation.

16

Differential effects of short-lasting appetitive and aversive classical conditioning upon cortical body maps in the barrel field of adult mice, a 2DG study

63%

Siucinska E., Kossut M.

Acta Neurobiologiae Experimentalis

|

1995

|

tom 55

|

nr 5

17

The distribution of 5-HT1 receptor sites in the visual structures of kitten's brain

63%

Skangiel-Kramska J., Kossut M.

Acta Neurobiologiae Experimentalis

|

1992

|

tom 52

|

nr 3

18

Learning-induced changes in alphaCaMkII and PSD95 protein levels in cortical synapses

63%

Skibinska A., Kossut M.

Acta Neurobiologiae Experimentalis

|

2001

|

tom 61

|

nr 3

19

Focal stroke in the barrel cortex of rats enhances ipsilateral response to vibrissal input

63%

Jablonka J., Kossut M.

Acta Neurobiologiae Experimentalis

|

2006

|

tom 66

|

nr 3

20

Brain activity mapping in mice during classical conditioning and roughness discrimination task

63%

Cybulska-Klosowicz A., Kossut M.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 5

Ograniczanie wyników

Inhibition in learning - induced cortical plasticity

Modifications of the single cortical vibrissal column

Engram

Contribution of the GABAergic system to cortical plasticity

Fear learning and the barrel cortex

Plastycznosc w rozwoju ukladu nerwowego

Neuromodulacja - magnetyczna i elektryczna ingerencja w pracę mózgu

Neurotransmitter receptors and the plasticity of the brain cortex

The impact of sensory experience on cortical function

Neuroplastycznosc i neurorehabilitacja

Glutamatergic and GABA-ergic involvement in learning-dependent plasticity of sensory cortex

Different forms of plasticity in the barrel cortex

Increase of gaba receptor biding activity after short lasting monocular deprivation in kittens

Short-term sensory learning does not alter Parvalbumin neurons in the barrel cortex of adult mice

The learning brain - activation during classical conditioning

Differential effects of short-lasting appetitive and aversive classical conditioning upon cortical body maps in the barrel field of adult mice, a 2DG study

The distribution of 5-HT1 receptor sites in the visual structures of kitten's brain

Learning-induced changes in alphaCaMkII and PSD95 protein levels in cortical synapses