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1

Farmakokinetyka paracetamolu u cielat rasy cb oraz mieszancow cb x hf w okresie postnatalnym

100%
Grochowina B., Janus K.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 05
571-573
The aim of this study was to compare the pharmacokinetics of paracetamol in calves of the BW (Black- -and-White) breed and cross-breed calves (BW × HF Holstein-Friesian) (50% HF). The effect of age on interbreed differences in the values of selected pharmacokinetic parameters of this model drug were also examined. The experiment was carried out on 20 healthy calves: 10 of BW breed and 10 cross-breed (50% HF). The paracetamol test was performed on calves aged 10, 20 and 40 days of life. The animals received this model drug per os at a dose of 5 mg/kg body weight. The concentration of paracetamol in plasma was determined by the spectrophotometric method. The pharmacokinetics of paracetamol were calculated through a non-compartmental method, using The TopFit computer software. The obtained results indicate that the age of calves had an influence on the values of pharmacokinetic parameters of paracetamol. We observed that most of the estimated pharmacokinetic parameters of this model drug differed significantly (P < 0.01) between 10, 20 and 40-day-old calves. It was stated that 10 and 20-day-old BW calves metabolized paracetamol faster compared to 50% HF calves, but the observed results differed insignificantly (P > 0.05). We also observed that 40-day-old 50% HF calves metabolized paracetamol at a significantly (P < 0.01) quicker rate compared to BW animals.
2

Wplyw wieku na farmakokinetyke paracetamolu u cielat

100%
Grochowina B., Janus K.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 02
193-198
The aim of the study was to investigate the effects of age on the pharmacokinetics of paracetamol (as a model drug) in calves. The experiment was carried out on 15 healthy BW (Black-and-White) breed calves. Paracetamol (5 mg/kg bw.) was administered per os on day ten, fourteen and twenty of the calves' lives. The concentration of a model drug in plasma was determined by the spectrophotometer method. Pharmacokinetic parameters were estimated through a non-compartmental method, using the TopFit computer program. The obtained results indicate that the age of calves significantly influenced the pharmacokinetic parameters of paracetamol. A significant increase in the maximum concentration of the drug was noted, as well as in the volume of distribution and metabolic clearance. A significant decrease in mean residence time, biological half-life and area under curve was also observed. The results obtained in the study suggest that the activity of enzymes involved in the metabolism of paracetamol increases with the age of calves. It was therefore concluded that age should obviously be taken into account when studying drug metabolism in calves
3

Proba oceny biotransformacyjnej aktywnosci watroby u cielat przy pomocy uproszczonego testu paracetamolowego

100%
Grochowina B., Janus K.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 09
1084-1086
The aim of the investigation was the modification of the paracetamol (as a model drug) test for calves. We examined if a precise determination of the pharmacokinetics of paracetamol (indirectly the activity of enzymes catalyzing the reaction of phase II of hepatic biotransformation) was possible using a simplified paracetamol test. The experiment was carried out on 15 healthy calves of BW (Black-and-White) breed. Paracetamol (5 mg/kg bw.) was administered per os on the tenth, twentieth and fourteenth days of the calves’ lives. The concentration of a model drug in plasma was determined by the spectrophotometric method in 10, as well as 3 and 4 samples. Pharmacokinetic parameters were estimated using a non-compartmental method, via the TopFit computer program. The values of pharmacokinetic parameters of paracetamol estimated in “simplified variants” significantly correlated (r = 0.874-0.985) with data obtained in a full test. The highest coefficients of the correlation was observed when the concentration of paracetamol was determined at 3, 4, 6 and 8 hours after the model drug administration. Summing up, it was determined that it is possible to evaluate precisely and indirectly the biotransformation activity in calves (activity of UDP-glucuronyltransferase and sulfonyltransferase) using a simplified variant of paracetasmol test, based on the determination of the concentration of the model drug in 3-4 blood samples.
4

Farmakokinetyka paracetamolu w osoczu krwi i slinie cielat

100%
Grochowina B., Janus K.
Medycyna Weterynaryjna
|
2006
|
tom 62
|
nr 06
686-689
The aim of the investigation was the pharmacokinetics of paracetamol (as a model drug) in plasma and saliva in calves at different ages. The experiment was carried out on 15 healthy calves of BW (Black-and- -White) breed. Paracetamol (5 mg/kg bw.) was administered per os on the tenth, twentieth and fourteenth days of the calves' lives. The concentration of the model drug in the plasma was determined by the spectrophotometric method. Pharmacokinetic parameters were estimated using a non-compartmental method by means of the TopFit computer program. It was determined that paracetamol concentration in the plasma and saliva was significantly different in many analyzed time points. Insignificant differences were observed in 10-day-old calves after 1.5, 2 and 3 hours after drug administration. In 20 and 40-day-old calves, insignificant changes were observed after 2 and 3 hours after paracetamol administrations. In all examined animals maximal paracetamol concentration was observed after 1 hour following drug administration. The obtained results indicate that saliva is not a good biological fluid for the determination the paracetamol pharmacokinetic parameters in calves.
5

Fenotyp acetylacji u cielat rasy cb oraz mieszancow cb x hf

71%
Janus K., Antoszek J., Suszycki S., Grochowina B., Muszczynski Z.
Medycyna Weterynaryjna
|
2003
|
tom 59
|
nr 07
643-646
6

Diurnal changes of antipyrine pharmacokinetics in calves feed “high-carbohydrate”food ration

71%
Antoszek J., Suszycki S., Grochowina B., Muszczynski Z., Janus K.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
7

Dobowe zmiany farmakokinetyki antypiryny u cielat zywionych dieta bogatobialkowa

61%
Janus K., Krolak J., Antoszek J., Suszycki S., Grochowina B., Muszczynski Z.
Medycyna Weterynaryjna
|
2004
|
tom 60
|
nr 08
886-889
8

The influence of “high-protein” food on antipyrine pharmacokinetics in Black-and-White breed and Black-and-White x Holstein-Friesian cross-breed calves

61%
Suszycki S., Krolak J., Antoszek J., Grochowina B., Janus K., Muszynski Z.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
9

Dobowe zmiany farmakokinetyki antypiryny u cielat zywionych dieta bogatoweglowodanowa

61%
Janus K., Juszczuk M., Kwiecien A., Antoszek J., Suszycki S., Muszczynski Z., Grochowina B.
Medycyna Weterynaryjna
|
2005
|
tom 61
|
nr 10
1177-1180
10

Farmakokinetyka antypiryny w osoczu krwi i slinie u cielat rasy cb oraz mieszancow cb x hf

61%
Janus K., Prusak E., Woroniecka R., Antoszek J., Suszycki S., Grochowina B.
Medycyna Weterynaryjna
|
2002
|
tom 58
|
nr 03
218-222
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