Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 5

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Napoleon Nikodem Cybulski 91854-1919)-the founder of Electrophysiological School in Cracow

100%
Smyda J., Wrobel A.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Napoleon Cybulski was one of the most prominent Polish physiologists. He defended his PhD thesis in 1885 and became the Chair of the Department of Physiology at the Faculty of Medicine of Jagiellonian University, till 1919. He is known as a founder of the physiology school in Cracow. One of his greatest achievements was the construction of a device for precise measurements of blood movement in the vessels – the photohemotachometer. It provided a better insight into the physiology and pathophysiology of the circulatory system. In the fi eld of endocrinology Cybulski, together with Szymonowicz, found out that adrenal extracts contain biologically active substances that elevate blood pressure. He was also a constructor of an extremely sophisticated microcalorimeter to measure the quantity of heat produced during isolated muscle contraction. He applied, for the fi rst time, condensator discharges to stimulate nerves and analyzed changes in the excitability of the muscles. Cybulski proved that the cause of the electrical excitability of tissue depends on the electrical energy and the time of its duration. Together with Adolf Beck, he performed the experiments on the sensory centers in the central nervous system by means of the observations of the electrical evoked potentials. They discovered the continuous electrical oscillations in the brain and recorded the negative electrical potentials in brain areas. This invention had the great contribution to the development of physiology.
2

Liliana Lubinska (1904-1990) - the pioneer of investigations on axonal transport and nerve regeneration

81%
Oderfeld-Nowak B., Skangiel-Kramska J., Gorska T., Smyda J.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
Professor Liliana Lubińska has been working in the Nencki Institute since 1933. In 1946 she has founded together with Professor Jerzy Konorski the Department of Neurophysiology in the Institute. Liliana Lubińska devoted practically her whole life to studies on peripheral nervous system with the main aim to elucidate the mechanism of functioning of the neuron with its small cell body and long axon. She has studied thus the events taking place during regeneration and Wallerian degeneration as well as the mechanisms of axonal transport. She has used simple methods elaborated and tested in every detail. In the late fi fties Professor Liliana Lubińska encouraged Professor Stella Niemierko – the biochemist, to begin joint studies on transport of some compounds along axons. The joint work on this project as well as concomitantly carried on studies with Professor Jirina Zelena, brought to a formulation of basic, largely citated and referred to, hypothesis of bidirectional movement of axoplasm. Liliana Lubińska was an outstanding scientist with strong personality and with very brought knowledge of neurobiological phenomena and a unique intellectual capacity for posing and solving scientifi c problems. She has been the author of several original papers and reviews of fundamental signifi cance, still frequently quoted in world literature. They had a great impact on neurobiology, infl uenced the research of many scientists and triggered a new line of experiments.
3

Attention related beta activity in the lateral-posterior nucleus of the cat

81%
Wrobel A., Ghazaryn A., Bekisz M., Smyda J.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 5
4

Stella Niemierko (1906-2006) - the founder of functional neurochemistry in Poland

81%
Oderfeld-Nowk B., Skangiel-Kramska J., Smyda J.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
All the long and most fruitful scientifi c activity of Professor Stella Niemierko has been inseparably connected with the Nencki Institute of Experimental Biology which she entered in 1926 as a thirdyear student. For many years she was involved in the studies of various aspects of phosphorus metabolism. In 1959 Stella Niemierko established the fi rst national team to introduce a neurochemical approach to systems based physiology. Four years later she offi cially founded the Laboratory of Neurochemistry which she guided until her retirement in 1977. She actively participated in its further development until the end of her life. Collaborative work between Professor Stella Niemierko and Professor. Liliana Lubińska led to signifi - cant advances in the fi eld of axonal transport. The major fi ndings which brought to a formulation of basic hypothesis of bidirectional movement of axoplasm were published in the leading scientifi c journals Nature and Science. Encouraged by Prof. Jerzy Konorski, she undertook the studies on neurochemical basis of learning and memory. She also initiated investigations concerning biochemical changes occurring in the brain after fi rst visual stimulation, which were awarded a national prize. Professor Niemierko has contributed to the development of neurochemical research projects in several centers in Poland gaining the respect and admiration of the whole Polish biochemical and neurobiological Community. She was honored member of the Polish Neuroscience Society.
5

Cholinegric modulation of frequency potentiation at cortical layer 6 input to posteromedial thalamic nucleus

61%
Nersisyan S., Bekisz M., Kublik E., Smyda J., Granseth B., Wrobel A.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Besides sensory input from whiskers, higher order posteromedial nucleus (PoM) of the thalamus, receives rich and complex cortical feedback projections of modulatory and driving type (from layer 6 and 5, respectively). The function of these recurrent pathways is under control of the brain stem neuromodulatory systems. In this study we investigated cholinergic influence on facilitatory properties of cortical layer 6 input to PoM cells. For this purpose we prepared “classical” thalamocortical slices from brains of young (21-28 days) rats. Such slices are suitable for studying the physiology of synapses made on PoM cells by axons from cortical layer 6, because fibers descending from layer 5 are mostly cut off. Membrane potential of PoM neurons was recorded by whole-cell patch-clamp method while cholinergic agonist carbachol (5-8 µM) was added to the bath to activate cholinergic receptors. To evoke excitatory postsynaptic potentials (EPSPs), repetitive series of 5 electrical stimuli at 20 Hz frequency (15 s inter-trial interval, baseline membrane voltage at -56 mV) were applied by stimulation electrode placed at the cortico-thalamic fiber tract in the internal capsule. Bicuculline was present in the bath to block GABAA receptors. We found that carbachol led to almost threefold decrease of the first EPSP’s amplitude in the train. At the same time, however, the ratio between the second and the first postsynaptic potential (paired pulse facilitation) became nearly two times bigger. Moreover, with activated cholinergic receptors, the following EPSPs in the train also grew faster in amplitude. Our results indicate that modulatory cholinergic system may increase the frequency potentiation of cortical layer 6 input to PoM, most likely due to decrease of transmitter release through activation of presynaptic cholinergic receptors. This research and NS was supported by the Foundation for Polish Science through International PhD Program in Neurobiology.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.