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Czynniki ostrej fazy w zawale serca i udarze mózgowym

100%

Ponikowski P., Sawicki G., Hanczycowna H., Malus-Gronowska D., Dobryszycka W.

Diagnostyka Laboratoryjna

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1989

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tom 25

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nr 1

2

Effect of short-term rapid ventricular pacing followed by pacing interruption on arterial blood pressure in healthy pigs and pigs with tachycardiomyopathy

59%

Skrzypczak P., Zysko D., Paslawska U., Noszczyk-Nowak A., Janiszewski A., Gajek J., Nicpon J., Kiczak L., Bania J., Zacharski M., Tomaszek A., Jankowska E. A., Ponikowski P., Witkiewicz W.

Polish Journal of Veterinary Sciences

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2014

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tom 17

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nr 1

Ventricular tachycardia may lead to haemodynamic deterioration and, in the case of long term persistence, is associated with the development of tachycardiomyopathy. The effect of ventricular tachycardia on haemodynamics in individuals with tachycardiomyopathy, but being in sinus rhythm has not been studied. Rapid ventricular pacing is a model of ventricular tachycardia. The aim of this study was to determine the effect of rapid ventricular pacing on blood pressure in healthy animals and those with tachycardiomyopathy. A total of 66 animals were studied: 32 in the control group and 34 in the study group. The results of two groups of examinations were compared: the first performed in healthy animals (133 examinations) and the second performed in animals paced for at least one month (77 examinations). Blood pressure measurements were taken during chronic pacing - 20 min after onset of general anaesthesia, in baseline conditions (20 min after pacing cessation or 20 min after onset of general anaesthesia in healthy animals) and immediately after short-term rapid pacing. In baseline conditions significantly higher systolic and diastolic blood pressure was found in healthy animals than in those with tachycardiomyopathy. During an event of rapid ventricular pacing, a significant decrease in systolic and diastolic blood pressure was found in both groups of animals. In the group of chronically paced animals the blood pressure was lower just after restarting ventricular pacing than during chronic pacing. Cardiovascular adaptation to ventricular tachycardia develops with the length of its duration. Relapse of ventricular tachycardia leads to a blood pressure decrease more pronounced than during chronic ventricular pacing.

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Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

59%

Kiczak L., Tomaszek A., Bania J., Paslawska U., Zacharski M., Janiszewski A., Rybinska I., Dziegiel P., von Haehling S., Ardehali H., Jankowska E. A., Ponikowski P.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 3

4

Technika implantacji sztucznego stymulatora serca u świni domowej w modelu przewlekłej niewydolności serca indukowanej tachykardią

59%

Janiszewski A., Paslawska U., Gajek J., Skrzypczak P., Noszczyk-Nowak A., Zosko D., Kiczak L., Bania J., Tomaszek A., Zacharski M., Nicpon J., Banasiak W., Jankowska E., Ponikowski P.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

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2011

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tom 48

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P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy

59%

Skrzypczak P., Zysko D., Paslawska U., Noszczyk-Nowak A., Janiszewski A., Kiczak L., Bania J., Zacharski M., Tomaszek A., Rybinska I., Nicpon J., Paslawski R., Gajek J., Jankowska E. A., Ponikowski P.

Bulletin of the Veterinary Institute in Puławy

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2013

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tom 57

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nr 3

The aim of the study was to assess the atrioventricular conduction in the model of porcine pacing induced tachycardiomyopathy. Fifty-one swine were examined: 27 were paced and 24 served as a control group. Every 4 weeks, the animals were anaesthetised for 1 h and an ECG Holter was performed. Thirty minutes after the onset of anaesthesia, P-R and R-R intervals were measured. Each result was assigned to the subgroup according to the animal's weight and the presence or absence of previous pacing. P-R interval was longer in animals after at least 4 weeks of rapid ventricular stimulation than in adjusted group of the animals according to the body mass. Multivariate analysis has showed that longer P-R interval was related to male gender, higher body mass, slower heart rate, and history of previous pacing. Chronic ventricular pacing led to the slowing of atrioventricular conduction. The presence of differences in the duration of R-R intervals between groups was only found in swine weighing 120-139 kg. The R-R interval was shorter in paced animals, whereas PR interval was longer in that group, indicating that PR prolongation is related to electrical or structural remodelling of the cardiac conductive tissue but not increased sympathetic nervous system activity, which is expected to produce corresponding changes in PR and R-R intervals.

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Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

59%

Tomaszek A., Kiczak L., Bania J., Paslawska U., Zacharski M., Janiszewski A., Noszczyk-Nowak A., Dziegiel P., Kuropka P., Ponikowski P., Jankowska E. A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 2

7

Duze zwierzeta modelem niewydolnosci serca

59%

Noszczyk-Nowak A., Jankowska E., Paslawska U., Janiszewski A., Kiczak L., Bania J., Tomaszek A., Zacharski M., Nicpon J., Ugorski M., Ponikowski P., Banasiak W.

Medycyna Weterynaryjna

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2010

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tom 66

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nr 06

378-382

Congestive heart failure is a clinical syndrome whose hallmarks are fatigue and dyspnea. Common pathophysiologic features of heart failure include changes in the structure of the left ventricle of the heart, function, and neurohormonal activation. A recapitulation of the heart failure phenotype in a large animal model can make it possible to translate basic science discoveries into clinical therapies. Models of myocardial infarction/ischemia, ischemic cardiomyopatyhy, ventricular pressure and volume overload and pacing- -induced dilated cardiomyopathy have been created for dogs, pigs and sheep to investigate heart failure and potential therapies. This article presents types of large animal models of heart failure, methods of their development and their clinical usefulness.

Ograniczanie wyników

Czynniki ostrej fazy w zawale serca i udarze mózgowym

Effect of short-term rapid ventricular pacing followed by pacing interruption on arterial blood pressure in healthy pigs and pigs with tachycardiomyopathy

Matrix metalloproteinase 9/neutrophil gelatinase associated lipocalin/tissue inhibitor of metalloproteinases 1 complexes are localized within cardiomyocytes and serve as a reservoir of active metalloproteinases in porcine female myocardium

Technika implantacji sztucznego stymulatora serca u świni domowej w modelu przewlekłej niewydolności serca indukowanej tachykardią

P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy

Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

Duze zwierzeta modelem niewydolnosci serca