Wyniki wyszukiwania

1

Effect of differentiating agents [all-trans retinoic acid and phorbol 12-myristate 13-acetate] on drug sensitivity of HL60 and NB4 cells in vitro

100%

Jasek E., Mirecka J., Litwin J. A.

Folia Histochemica et Cytobiologica

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2008

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tom 46

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nr 3

323-330

2

Effect of nebivolol treatment on atherosclerotic plaque components in apoE-knockout mice

88%

Pyka-Fosciak G., Jawien J., Gajda M., Jasek E., Litwin J. A.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 6

3

Daily rhythm of synapse turnover in mouse somatosensory cortex

76%

Jasinska M., Grzegorczyk A., Jasek E., Litwin J. A., Kossut M., Barbacka-Surowiak G., Pyza E.

Acta Neurobiologiae Experimentalis

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2014

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tom 74

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nr 1

The whisker representations in the somatosensory barrel cortex of mice are modulated by sensory inputs associated with animal motor behavior which shows circadian rhythmicity. In a C57/BL mouse strain kept under a light/dark (LD 12:12) regime, we observed daily structural changes in the barrel cortex, correlated with the locomotor activity level. Stereological analysis of serial electron microscopic sections of the barrel cortex of mice sacrificed during their active or rest period, revealed an increase in the total numerical density of synapses and in the density of excitatory synapses located on dendritic spines during the rest, as well as an increase in the density of inhibitory synapses located on double-synapse spines during the active period. This is the first report demonstrating a daily rhythm in remodeling of the mammalian somatosensory cortex, manifested by changes in the density of synapses and dendritic spines. Moreover, we have found that the excitatory and inhibitory synapses are differently regulated during the day/night cycle.

4

Expression of basal cell marker revealed by RAM11 antibody during epithelial regeneration in rabbits

76%

Lis G. J., Jasek E., Litwin J. A., Gajda M., Zarzecka J., Cichocki T.

Folia Histochemica et Cytobiologica

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2010

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tom 48

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nr 1

89-92

5

Sodium hydrosulfide exerts a transitional attenuating effect on spermatozoa migration in vitro

76%

Wilinski B., Wilinski J., Gajda M., Jasek E., Somogyl E., Glowacki M., Sliwa L.

Folia Biologica

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2015

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tom 63

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nr 2

6

Circadian synaptic plasticity in the mouse barrel cortex

76%

Jasinska M., Grzegorczyk A., Jasek E., Litwin J. A., Kossut M., Barbacka-Surowiak G., Pyza E.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr Suppl.1

Mice show circadian rhythms in behaviour and metabolic processes but also in neuronal plasticity associated with the sensory input to the whisker representations in the somatosensory (barrel) cortex. We analyzed daily structural changes in the barrel cortex of the C57/BL mice in a light/dark (LD 12:12) regime and in constant darkness (DD). Using serial EM sections of the barrel cortex of mice sacrificed during their active or rest period, we observed up-regulation of the density of excitatory synapses located on single-synapse spines during the rest period in LD 12:12 and an increase in the density of inhibitory synapses located on double-synapse spines during the active period in LD 12:12 and DD. In conclusion, the mouse barrel cortex shows daily changes in the density of synapses and dendritic spines similar to the daily pattern of locomotor activity of the animals. Moreover, the excitatory and inhibitory synapses are differently regulated during the day/night cycle. This example of plasticity seems to be regulated by both, the circadian clock and light. Supported by a grant to MJ (2011/01/D/NZ3/00207).

7

Elevated serum osteoprotegerin is associated with decreased osteoclastic differentiation in stenotic aortic valves

64%

Lis G. J., Czubek U., Jasinska M., Jasek E., Laboda A., Dulak J., Nessler J., Sadowski J., Litwin J. A.