Wyniki wyszukiwania

1

Episjalina - nowopoznany skladnik glikokaliksu i blony komorkowej komorek nablonkowych

100%

Gindzienski A., Zwierz K.

Postępy Biochemii

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1997

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tom 43

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nr 2

80-84

2

Aktywność N-acetylo-B-D-heksozoaminidazy i jej izoenzymów w surowicy krwi, moczu i aspiratach treści dwunastniczej chorych z giardiazą

100%

Gabrylewska A., Zwierz K.

Diagnostyka Laboratoryjna

|

2004

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tom 40

|

nr 3

3

Śluz i mucyna - problem biochemiczny i medyczny

100%

Gindzienski A., Zwierz K.

Postępy Biochemii

|

1991

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tom 37

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nr 3-4

4

Niemucynowe bialka sliny o wysokim stopniu homologii lancucha polipeptydowego

81%

Zalewska A., Pietruska M. D., Knas M., Zwierz K.

Postępy Higieny i Medycyny Doświadczalnej

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2001

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tom 55

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nr 5

733-754

5

Aktywność N-acetylo-B-D-heksozoaminidazy i jej izoenzymów w treści dwunastniczej i surowicy krwi chorych z giardiazą

81%

Gabrylewska A., Knas M., Dudzik D., Zwierz K.

Diagnostyka Laboratoryjna

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2006

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tom 42

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nr 1

6

Endoglikozydazy i glikoamidazy

81%

Stypulkowska A., Zwierz P., Zwierz K.

Postępy Biochemii

|

2004

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tom 50

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nr 1

82-88

7

Diagnostyka laboratoryjna zespolu uzaleznienia od alkoholu etylowego

81%

Markowski T., Arciuch L. P., Zwierz K., Bakush A. A.

Postępy Higieny i Medycyny Doświadczalnej

|

2001

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tom 55

|

nr 1

113-120

8

Aktywność N-acetylo-B-D-heksozoaminy i jej izoenzymów w moczu chorych z giardiazą

81%

Gabrylewska A., Knas M., Dudzik D., Zwierz K.

Diagnostyka Laboratoryjna

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2005

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tom 41

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nr 2

9

Activity of α-fucosidase in serum and urine of smoking patients with colon adenocarcinoma

81%

Szajda S.-D., Snarska J., Zwierz K.

Acta Biochimica Polonica

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2007

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tom 54

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nr Supplement 4

10

The role of mucus and its components in protection and repair within the alimentary tract mucosa: Polish experience

81%

Gindzienski A., Zwierz K., Sarosiek J.

Journal of Physiology and Pharmacology. Supplement

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2003

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tom 54

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nr 3

127-144

The Gastroenterology Research Laboratory at New York Medical College, New York City, NY, directed by Prof. Dr. George B. Jerzy Glass and after his retirement by Prof. Dr. Bronislaw L. Slomiany and Prof. Dr. Amalia Slomiany served as a lunching pad for successful careers in exploration of mucus for Dr. Andrzej Gindzienski and Dr. Krzysztof Zwierz and Janusz Badurski at the Medical School in Bialystok, Poland as well as Dr. Jerzy Sarosiek at Gastroenterology Research Laboratory, University of Virginia Health Sciences Center, Charlottesville, VA and currently, Gastroenterology Research Laboratory, Kansas University Medical Center, Kansas City, KS, USA. The dynamic and insightful research endeavors implemented at the Medical School of Bialystok revealed new information regarding enzymatic pathways of mucin synthesis especially its carbohydrate components such as hexosamines. These discoveries become instrumental in our understanding of the alimentary tract mucin synthesis and function in health and disease. Similarly innovative mucus research conducted across the Atlantic Ocean uncovered the novelty of mucin elaborated within the esophageal submucosal mucous glands in humans by demonstration that its chemical characteristics are different both from human salivary and gastric mucins. In addition, a novel method for the measurement of the thickness of the gastric mucus layer ex vivo in humans has also been developed. These pioneering works are continued at both mucus exploration centers attracting younger generation of investigators enticed by the mystery of the structure and function of the mucus barrier and its leading role in mucosal protection against injury as well as immediate and unequivocal contribution to mucosal repair and reconstitution process.

11

Aktywność katepsyny D w osoczu krwi chorych na nowotwory płuc

81%

Saied Salloun M., Roszkowska-Jakimiec W., Kreczko S., Zwierz K.

Diagnostyka Laboratoryjna

|

2000

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tom 36

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nr 2

12

A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

81%

Czykier E., Dzieciol J., Zalewska A., Zwierz K.

Folia Morphologica

|

2003

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tom 62

|

nr 3

305-307

The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm³ affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm³, while the group II animals were given 50 mg Cd/dm³. The highest concentration of cadmium was observed in group II, with a concomitant increase in the number of PCNA-positive cells. In group I, cadmium concentration was significantly less compared to group II, and there were fewer PCNA-positive cells. The reaction for Ki-67 in both experimental groups was negative.

13

N-acetylo-beta-D-heksozoaminidaza - enzym chorob Tay-Sachsa i Sandhoffa

81%

Zwierz K., Juszkiewicz J., Arciuch L., Gindzienski A.

Postępy Biochemii

|

1992

|

tom 38

|

nr 3

127-132

14

N-acetylo-Beta-D-heksozoaminidaza płynu stawowego jako ważny wskaźnik choroby reumatoidalnej

81%

Marciniak J., Popko J., Zwierz K.

Diagnostyka Laboratoryjna

|

2004

|

tom 40

|

nr 3

15

Exoglycosidases profile of patients with rheumatiod arthritis and osteoarthritis

81%

Popko J., Zwierz K., Guszczyn T.

Acta Biochimica Polonica

|

2006

|

tom 53

|

nr Supplement 1

16

Molekularne mechanizmy regulacji transportu substancji drobnoczasteczkowych w obrebie hepatocyta

81%

Zwierz K., Wielgat P., Borzym-Kluczyk M.

Postępy Higieny i Medycyny Doświadczalnej

|

2003

|

tom 57

|

nr 1

91-116

17

Role of N-acetyl-beta-D-hexosaminidase in cholesteatoma tissue

81%

Olszewska E., Olszewski S., Borzym-Kluczyk M., Zwierz K.

Acta Biochimica Polonica

|

2007

|

tom 54

|

nr 2

Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-gangliosides and glycosaminoglycans (GAGs). In this study the activities of HEX were measured in cholesteatoma tissue and in normal skin to demonstrate a possible role of HEX in bone resorption in the area adjacent to cholesteatoma. Cholesteatomas (n = 21) and normal adult retroauricular skin (controls, n = 21), were collected from patients during surgery due to chronic otitis media. In 20 of 21 specimens a significantly higher activity of HEX was observed in cholesteatoma tissue compared with that in normal skin. Mean release of HEX from the activated cells was 68.55 ± 30.77 nkat/g wet tissue in cholesteatoma and 31.79 ± 10.02 nkat/g wet tissue in skin specimens. It may explain the process of bone resorption in the area adjacent to cholesteatoma, i.e. ossicles or temporal bone. This study suggests that drugs inhibiting HEX activity, such as iminocyclitols, may be useful in cholesteatoma treatment.

18

Isoenzymes of N-acetyl-beta-hexosaminidase

81%

Zwierz K., Zalewska A., Zoch-Zwierz W.

Acta Biochimica Polonica

|

1999

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tom 46

|

nr 3

Biological significance, structure and posttranslational processing of N-acetyl-β-hexosaminidase isoenzymes are described. Clinical application of N-acetyl-β-hexosaminidase is also reviewed.

19

Urinary activities of N-acetyl-beta-D-glucosaminidase and its isoenzyme B in cadmium-exposed rats

81%

Brzoska M. M., Stypulkowska A., Zwierz K., Moniuszko-Jakoniuk J.

Polish Journal of Environmental Studies

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2004

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tom 13

|

nr 2

This paper aims to assess the relationship between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and its isoenzyme B (NAG-B) and cadmium (Cd) concentration in the urine as well as to evaluate which of these lysosomal enzymes may be a more useful biomarker for the monitoring of Cd-induced tubular damage. For this purpose we have used an experimental model in rats chronically exposed to Cd in which we noted damage to the proximal tubules, including lysosomes. In rats intoxicated with 5 mg Cd/dm3, the urinary activities of NAG and NAG-B increased after 12 weeks of treatment, while at 50 mg Cd/dm3 - activities increased already after the 1st week. The urinary Cd excretion in Cd-exposed rats, but not in the non-exposed ones, positively correlated with the activities of NAG and NAG-B. A positive correlation which was observed between NAG and NAG-B activities was stronger in Cd-exposed animals than in those not exposed. The results of the present and our previous histopathological and histoenzymatic studies, confirm the usefulness of total NAG and NAG-B as sensitive markers of proximal tubular injury for the monitoring of chronic exposure to Cd. Taking into account the strong correlation between the total NAG and its isoenzyme B, similar correlation coefficients between their activities and Cd concentration in urine and simplicity of total NAG determination compared to that of NAG-B, one can conclude that the determination of total NAG is suitable for the monitoring of exposure to Cd. As the urinary activity of total NAG is a sum of activities of several isoenzymes, which may be influenced by various factors, and the intralysosomal localization of NAG-B, we hypothesize that NAG-B should be recommended as a sensitive and useful marker for routine monitoring of chronic exposure to Cd.

20

The carbohydrate moiety of human glycophorin in CDG syndrome

81%

Krotkiewska B., Zwierz K., Krotkiewski H.

Acta Biochimica Polonica

|

1999

|

tom 46

|

nr 2

Human glycophorin, the major sialoglycoprotein of erythrocyte membranes, was isolated from erythrocytes of healthy individuals and four patients with CDG syndrome. Sugar analysis revealed lower carbohydrate content in three out of four CDG-glycophorin samples. In order to characterize closer the glycosylation differences between glycophorin samples in health and disease, reaction with four biotinylated lectins was performed, using ELISA procedure on polystyrene microplates. Results obtained so far strongly suggest that both N- and O-glycans of glycophorin are affected in CDG syndrome.

Ograniczanie wyników

Episjalina - nowopoznany skladnik glikokaliksu i blony komorkowej komorek nablonkowych

Aktywność N-acetylo-B-D-heksozoaminidazy i jej izoenzymów w surowicy krwi, moczu i aspiratach treści dwunastniczej chorych z giardiazą

Śluz i mucyna - problem biochemiczny i medyczny

Niemucynowe bialka sliny o wysokim stopniu homologii lancucha polipeptydowego

Aktywność N-acetylo-B-D-heksozoaminidazy i jej izoenzymów w treści dwunastniczej i surowicy krwi chorych z giardiazą

Endoglikozydazy i glikoamidazy

Diagnostyka laboratoryjna zespolu uzaleznienia od alkoholu etylowego

Aktywność N-acetylo-B-D-heksozoaminy i jej izoenzymów w moczu chorych z giardiazą

Activity of α-fucosidase in serum and urine of smoking patients with colon adenocarcinoma

The role of mucus and its components in protection and repair within the alimentary tract mucosa: Polish experience

Aktywność katepsyny D w osoczu krwi chorych na nowotwory płuc

A preliminary study of the submandibular gland of the rat after long-term cadmium intoxication

N-acetylo-beta-D-heksozoaminidaza - enzym chorob Tay-Sachsa i Sandhoffa

N-acetylo-Beta-D-heksozoaminidaza płynu stawowego jako ważny wskaźnik choroby reumatoidalnej

Exoglycosidases profile of patients with rheumatiod arthritis and osteoarthritis

Molekularne mechanizmy regulacji transportu substancji drobnoczasteczkowych w obrebie hepatocyta