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1

The effects on 8-OH-DPAT on food intake in non- and food-deprived mice

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Brosda J., Muller N., Bert B., Fink H.
Acta Neurobiologiae Experimentalis
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2011
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tom 71
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nr S
Brain serotonin (5-HT) plays an important role in the regulation of food intake. The ingestive effects of 5-HT are mediated by a number of different receptor subtypes. The 5-HT1A receptor agonist 8-OH-DPAT produces hyperphagia or a decrease of food intake depending on animal feeding regime. These hyper- and hypophagic effects of the 5-HT1A receptor agonist have been the subject of many studies mostly carried out in rats. However, there is still little known if (1) the effects are mediated by presynaptic 5-HT1A autoreceptors in the raphe nuclei or by postsynaptic 5-HT1A receptors in serotonergic terminal structures and if (2) 8-OHDPAT has similar effects in other species. This study investigates the impact of 8-OH-DPAT administration on feeding behaviour in non- and food-deprived NMRI and C57BL mice as well as transgenic L35 mice, characterized by an overexpression of postsynaptic 5-HT1A receptors. Additionally, the microstructure of feeding, water intake and home cage activity were examined. 8-OH-DPAT increased food intake in non-deprived NMRI but not in C57BL mice and induced a hypophagic effect in food-deprived NMRI and C57BL mice. Preliminary data indicate neither a difference in feeding behaviour in L35 mice after 8-OH-DPAT administration nor a variety in the other parameters measured compared to control mice. These results suggest a central role for the 5-HT1A receptor on feeding behaviour in mice, in which the hyperphagic effect of 8-OH-DPAT is most likely mediated by 5-HT1A autoreceptors. Understanding the neurophysiology role of the 5-HT system on food intake may help to achieve new insights in disturbances of eating and body weight disorders.
2

CO2, isoflurane, and sevoflurane: humane induction of euthanasia in mice?

100%
Marquardt N., Fink H., Bert B.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Carbon dioxide (CO2) is commonly used for euthanasia in mice but this method has been strongly criticised concerning animal welfare. Alternatives have not been sufficiently tested. Here, we investigate distress induced by exposure to CO2, isoflurane (Iso), and sevoflurane (Sevo). NMRI mice were exposed to 100% CO2 with different filling rates (20% (CO2 20), 60% (CO2 60), CO2 100% (CO2 100) of chamber volume/min) or Iso and Sevo in different concentrations (Iso 2%, Iso 5%, Sevo 4.8%, Sevo 8%). Control animals received airflow. We measured changes in behaviour, and vocalisations during induction until surgical tolerance (ST) or during 5 min of air exposure. Then, mice were decapitated and blood glucose, plasma adrenaline (A) and noradrenaline (NA) were measured. ST was reached fastest after exposure to CO2 100, followed by CO2 60,
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