Parasitic infestation and atopic diseases have common features. The aim of our study was to evaluate the occurrence of Trichinella and Echinococcus seropositivity in children with atopic diseases. The study group involved 72 children aged from 2,5 to 18 years with asthma and allergic rhinitis. The control group comprised 30 children without allergic diseases. In 12 children with atopic diseases the serological tests were positive for Trichinella spiralis, in 11 for Echinococcus spp. and in 5 both for Trichinella and Echinococcus. In control group the serological tests were positive in 3,6 and 3 children respectively. There were no differences in occurrenee of positive results of serological tests in children with atopy and children without alillergic diseases.
The high infant mortality rate in Poland is influenced primarily by an excessive number of low-weight births, which are most often associated with prematurity. Among important causes of premature, we have to name economic situation, women' health condition during progenitive period and also their vices. Patients and methods. 100 questionnaires, obtained from the parents preterm children during hospitalization in the Deparment of Paediatric Propedeutics by the years 1995-1998, were analysed. The following data were collected: number and course of gestation (and also vices) and delivery, data about sibilings, data about parents (age, place of birth, origin, place of residence, level of education, profession) and apartment's conditions. Results. We obtained results: the great percentage of mothers presented pathology of gestation period: young mothers - 18%, teenage mothers 5.5%, with body weight deficit (Body Mass Index <19) - 26%, smoking cigarettes - 25%. The majority number of families had bad apartments' condition. Conclusions. The high rate of mothers of preterm babies presented pathology of pregnancies.
The aim of the study is proteomic analysis of the plasma profile in children with recurrent bone fractures. The study involved 16 children: 6 patients with recurrent low-energy fractures and normal bone mass and 10 with osteogenesis imperfecta. In the analysis of the protein profile, the two-dimensional protein electrophoresis was used (Ettan DALT II, Amersham Bioscience). The images of protein gels were compared with controls. The protein spots with changed expression were cut from the gel and the amino acid sequence was analyzed with the mass spectrometry method (Q-Tof PremierTM API MASS SPECTROMETR, Waters) for protein identification. The most prevalent protein with changed expression, with respect to controls, was haptoglobin observed in 6 patients with a severe form of osteogenesis imperfecta. Increased haptoglobin concentration in these patients was confirmed by the ELISA method. Peptides corresponding to alpha-1 acid glycoprotein and serum amyloid P-component, apolipoprotein A-I, and transthyretin were detected in one, two and three children, respectively. Conclusions: 1) The results show increased haptoglobin which may be suggestive of an inflammatory component taking part in the course of osteogenesis imperfecta. 2) Further studies to explain the possible relationship of this protein with increased bone fragility are necessary.
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