Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?

• Autorzy: Szweda M. , Szarek J. , Lew M. , Szarek-Beska A. , Gulda D.
• Języki publikacji: EN

Abstrakty

EN

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were performed before and on the 21 day treatment with robenacoxib (1), robenacoxib, herbal solution with liquorice extract (2), placebo – an empty capsule (3). There were 5 animals in each group. The greatest microscopic damage in the colon was observed in animals which received robenacoxib. Plant drug administration reduced the severity of lesions in the colon when administered with robenacoxib (ARI = – 0.15). Conclusion: concurrent administration of liquorice extract and plant solution with robenacoxib was associated with significant decreased severity of the robenacoxib-induced colonic mucosal lesions.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 4
• Opis fizyczny: p.793-798,fig.,ref.

Twórcy

autor

Szweda M.

• Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 13, 10-719 Olsztyn, Poland

autor

Szarek J.

• Department of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 13, 10-719 Olsztyn, Poland

autor

Lew M.

• Department of Surgery and Radiology with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 14, 10-719 Olsztyn, Poland

autor

Szarek-Beska A.

• Veterinary Practice „Pulsar”, Wiecherta St. 27A, 10-691 Olsztyn, Poland

autor

Gulda D.

• Department of Sheep, Goat and Fur Bearing Animal Breeding, University of Science and Technology, Kordeckiego 20F, 85-225 Bydgoszcz, Poland

Bibliografia

• Almansori M, Kovithavongs T, Qarni MU (2005) Cyclooxygenase-2 inhibitor-associated minimal change disease. Clin Nephrol 63: 381-384.
• Bernardi M, D’Intino PE, Trevisani F, Cantelli-Forti G, Raggi MA, Turchetto E, Gasbarrini G (1994) Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Life Sci 55: 863-872.
• Bjarnason I, Hayllar J, MacPherson AJ, Russell AS (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Scand J Gastroenterol 104: 1832-1847.
• Blumenthal M, Goldberg A, Brinckmann J, Foster S (2000) Licorice root. In: Herbal medicine – Expanded Commission E Monographs. American Botanical Council, Austin, USA, pp 233-239.
• Chen Q, Zhang H (1990) Clinical study on 118 cases of ulcerative colitis treated by integration of traditional Chinese and Western medicine. JTCM 19: 163-165.
• Deneuche AJ, Dufayet C, Goby L, Fayolle P, Desbois C (2004) Analgesic comparison of meloxicam or ketoprofen for orthopedic surgery in dogs. Vet Surg 33: 650-660.
• Frondoza CG, Sohrabi A, Polotsky A, Phan PV, Hungerford DS, Lindmark L (2004) An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cell Dev Biol Anim 40: 95-101.
• Fujimori S, Seo T, Gudis K, Ehara A, Kobayashi T, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C (2009) Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy. Gastrointest Endosc 69: 1339-1346.
• Gruet P, Seewald W, King JN (2013) Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial. BMC Vet Res 9: 92.
• Gruet P, Seewald W, King JN (2011) Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopedic surgery in dogs. Am J Vet Res 72: 184-193.
• Huo HZ, Wang B, Liang YK, Bao YY, Gu Y (2011) Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. Int J Mol Sci 12: 6529-6543.
• Jackson LM, Wu KC, Mahida YR, Jenkins D, Hawkey CJ (2000) Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. Gut 47: 762-770.
• Jacobs G, Collins-Kelly L, Lappin M, Tyler D (1990) Lymphocytic-plasmacytic enteritis in 24 dogs. J Vet Intern Med 4: 45-53.
• Jankowski M, Spużak J, Kubiak K, Glińska-Suchocka K, Biernat M, Kiełbowicz Z (2015) Risk factors of gastric ulcers in dogs. Pak Vet J 35: 93-97.
• Jones RD, Baynes RE, Nimitz CT (1992) Nonsteroidal anti-inflammatory drug toxicosis in dogs and cats: 240 cases (1989-1990). J Am Vet Med Assoc 201: 475-477.
• King JN, Dawson J, Esser RE, Fujimoto R, Kimble EF, Maniara W, Marshall PJ, O’Byrne L, Quadros E, Toutain PL, Lees P (2009) Preclinical pharmacology of robenacoxib: a novel selective inhibitor of cyclooxygenase-2. J Vet Pharmacol Ther 32: 1-17.
• King JN, Rudaz C, Borer L, Jung M, Seewald W, Lees P (2010) In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study. Res Vet Sci 88: 497-506.
• Kleinschmidt S, Meneses F, Nolte I, Hewicker-Trautwein M (2006) Retrospective study on the diagnostic value of full-thickness biopsies from the stomach and intestines of dogs with chronic gastrointestinal disease symptoms. Vet Pathol 43: 1000-1003.
• Langmead L, Rampton DS (2001) Review article: herbal treatment in gastrointestinal and liver disease – benefits and dangers. Aliment Pharmacol Ther 15: 1239-1252.
• Lascelles BD, Hansen BD, Roe S, DePuy V, Thomson A, Pierce CC, Smith ES, Rowinski E (2007) Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis. J Vet Intern Med 21: 410-416.
• Luna SP, Bastlio AC, Steagall PV, Machado LP, Moutinho FQ, Takahira RK, Brand4o CV (2007) Evaluation of adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen and meloxicam in dogs. Am J Vet Res 68: 258-264.
• Morris TJ, Calcraft BJ, Rhodes J, Hole D, Morton MS (1974) Effect of deglycyrrhizinised liquorice compound on the gastric mucosal barrier of the dog. Digestion 11: 355-363.
• Poppenga RH (2001) Herbal medicine: potential for intoxication and interactions with conventional drugs. Clin Tech Small Anim Pract 17: 6-18.
• Sakamoto C, Sugano K, Ota S, Sakaki N, Takahashi S, Yoshida Y, Tsukui T, Osawa H, Sakurai Y, Yoshino J, Mizokami Y, Mine T, Arakawa T, Kuwayama H, Saigenji K, Yakabi K, Chiba T, Shimosegawa T, Sheehan JE, Perez-Gutthann S, Yamaguchi T, Kaufman DW, Sato T, Kubota K, Terano A (2006) Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan. Eur J Clin Pharmacol 62: 765-772.
• Smart HL, Mayberry JF, Atkinson M (1986) Alternative medicine consultations and remedies in patients with the irritable bowel syndrome. Gut 27: 826-828.
• Viegi L, Pieroni A, Guarrera PM, Vangelisti R (2003) A review of plants used in folk veterinary medicine in Italy as basis for a databank. J Ethnopharmacol 89: 221-244.

Identyfikatory

DOI

10.1515/pjvs-2015-0103