PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2013 | 57 | 3 |

Tytuł artykułu

Pituitary adenylate cyclase activating peptide-27 – like immunoreactive nerve fibers in the mucosal layer of canine gastrointestinal tract in physiology and during inflammatory bowel disease

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Changes in the density of mucosal pituitary adenylate cyclase activating peptide-27 -like immunoreactive (PACAP-27 - LI) nerve fibers within various parts of the canine gastrointestinal (GI) tract during inflammatory bowel disease (IBD) were investigated. The distribution of nerves were studied, using a single-labelling immunofluorescence technique, in the mucosal layer of canine stomach, duodenum, jejunum, and descending colon. Canine IBD caused an increase in the density of PACAP- 27-LI mucosal nerves in all studied parts of GI tract. The results suggest that PACAP in the nervous system may be involved in pathological processes during IBD.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

57

Numer

3

Opis fizyczny

p.375-380,fig.,ref.

Twórcy

autor
  • Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957 Olsztyn, Poland
autor
  • Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-957 Olsztyn, Poland
autor
  • Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-957 Olsztyn, Poland

Bibliografia

  • 1. Abad C., Martinez C, Leceta J., Gomariz R.P., Delgado M.: Pituitary adenylate cyclase activating polypeptide inhibits collagen-induced arthritis: an experimental immunomodulatory therapy. J Immunol 2001, 167, 3182-3189.
  • 2. Allenspach K., Wieland B., Grone A., Gaschen F.: Chronic enteropathies in dogs, evaluation of risk factors for negative outcome. J Vet Int Med 2007, 21, 700- 708.
  • 3. Armstrong B.D., Abad C., Chhith S., Cheung-Lau G., Hajji O.E., Nobuta H., Washek J.A.: Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide (PACAP). Neuroscience 2008, 151, 63-73.
  • 4. Azuma Y.T., Hagi K., Shintani N., Kuwamura M., Nakajima H., Hashimoti H., Baba A., Takeuchi T.: PACAP provides colonic protection against dextran sodium sulfate induced colitis. J Cell Physiol 2008, 216, 111-119.
  • 5. Dejda A., Seaborn T., Bourgault S., Touzani O., Fournier A., Vaudry H., Vaudry D.: PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action. Peptides 2011, 32, 1207-1216.
  • 6. Delgado M., Abad C., Martinez C., Juarranz M.G., Leceta J., Ganea D., Gomariz R.P.: PACAP in immunity and inflammation. Ann N Y Acad Sci 2003, 992. 141-157.
  • 7. Ferencz A., Kiss P., Weber G., Helyes Z., Shintani N., Baba A., Reglodi D.: Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice. J Mol Neurosci 2010, 42, 435-442.
  • 8. Fox-Threlkeld J.A., McDonald T.J., Woskowska Z., Iesaki K., Daniel E.E.: Pituitary adenylate cyclase-activating peptide as a neurotransmitter in the canine ileal circular muscle. J Pharmacol Exp Ther 1999, 290, 66-75.
  • 9. Fuchs M., Adermann K., Raab H R., Forssmann W.G., Kuhn M.: Pituitary adenylate cyclase activating polypeptide: a potent activator of human intestinal ion transport. Ann N Y Acad Sci 1996, 805, 640-647.
  • 10. Godlewski J., Lakomy M.: Changes in vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide and neuropeptide Y-ergic structures of the enteric nervous system in the carcinoma of the human large intestine. Folia Histochem Cytobiol 2010, 48, 208-216.
  • 11. Gonkowski S., Kaminska B., Burlinski P., Kroll A., Calka J.: The influence of drug-resistant ulcerative colitis on the number of cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) mucosal nerve fibres of the descending colon in children. Przegląd Gastroenterologiczny 2009, 4, 147-151.
  • 12. Gonkowski S., Burliński P., Skobowiat C., Majewski M., Calka J.: Inflammation- and axotomy-induced changes in galanin-like immunoreactive (GAL-LI) nerve structures in the porcine descending colon. Acta Vet Hung 2010, 58, 91 -103.
  • 13. Gonkowski S., Calka J.: Changes in the somatostatin (SOM)- like immunoreactivity within nervous structures of the porcine descending colon under various pathological factors. Exp Mol Pathol 2010, 88, 416-423.
  • 14. Gonkowski S., Calka J.: Changes in pituitary adenylate cyclase- activating peptide 27-like immunoreactive nervous structures in the porcine descending colon during selected pathological processes. Mol Neurosci 2012, 48, 777-787.
  • 15. Helyes Z., Pozsgai G., Börzsei R.J., Németh R., Bagoly T.L., Márk L., Pintèr E., Tóth G., Elekes K., Szolcsányi J., Reglodi D.: Inhibitory effect of PACAP-38 on acute neurogenic and nonneurogenic inflammatory processes in the rat. Peptides 2007, 28, 1847-1855.
  • 16. Jergens A.E., Schreiner C.A., Frank D.E., Niyo Y., Ahrens F.E., Eckersall P.D., Benson T.J., Evans R.: A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med 2003, 17, 291-297.
  • 17. Jongsma H., Danielsen N., Sundler F., Kanje M.: Alteration of PACAP distribution and PACAP receptor binding in the rat sensory nervous system following sciatic nerve transection. Brain Res 2000, 853, 186-196.
  • 18. Kanekar S., Gandham M., Lucero M.T.: PACAP protects against TNFa-induced cell death m olfactory epithelium and olfactory placodal cell lines. Mol Cell Neurosci 2010, 45. 345-54.
  • 19. Läuffer J.M., Modlin I.M., Tanga L.H.: Biological relevance of pituitary adenylate cyclase-activating polypeptide (PACAP) in the gastrointestinal tract. Regul Pept 1999, 84, 1-12.
  • 20. Mao Y.K., Wang Y.F., Moogk C., Fox-Threlkeld J.E., Xiao Q., McDonald T.J., Daniel E.E.: Locations and molecular forms of PACAP and sites and characteristics of PACAP receptors in canine ileum. Am J Physiol 1998, 274, 217-225.
  • 21. Miyata A., Arimura A., Dahl R R., Minamino N., Uehara A., Jiang L., Culler M.D., Coy D.H.: Isolation of a novel 38 residuehypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 1989, 164, 567-574.
  • 22. Moller K., Reimer M., Ekblad E., Hannibal J., Fahrenkrug J., Kanje M., Sundler F.: Hie effects of axotomy and preganglionic denervation on the expression of pituitary adenylate cyclase activating peptide (PACAP), galanin and PACAP type 1 receptors in the rat superior cervical ganglion. Brain Res 1997, 775, 166-182.
  • 23. Packey C.D., Sartor R.B.: Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr Opm Infect Dis 2009, 22, 292-301.
  • 24. Philips R.J., Powley T.L.: Innervation of the gastrointestinal tract: patterns of aging. Auton Neurosci 2007, 136, 1-19.
  • 25. Sandgren K., Lin Z., Ekblad E.: Differential effects of VIP and PACAP on survival of cultured adult rat myenteric neurons. Regul Pept 2003, 111, 211-217.
  • 26. Simpson J., Sundler F., Humes D.J., Jenkins D., Scholefield J.H., Spiller R.C.: Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms. Neurogastroenterol Motil 2009, 21, 847-858.
  • 27. Skobowiat C., Gonkowski S., Calka J.: Phenotyping of sympathetic chain ganglia (SChG) neurons in porcine colitis. J Vet Med Sci 2010, 72, 1269-1274.
  • 28. Suchodolski J.S., Xenouli, P.G., Paddock C.G., Steiner J.M., Jergens A.E.: Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Vet Microbiol 2010, 19, 394-400.
  • 29. Takei N., Skoglosa Y., Lindholm D.: Neurotrophic and neuroprotective effects of pituitary adenylate cyclase activating polypeptide (PACAP) on mesencephalic dopaminergic neurons. J Neurosci Res 1998, 54, 698-706.
  • 30. Vaudry D., Pamantung T.F., Basille M., Rousselle C., Fournier A., Vaudry H., Beauvillain J.C., Gonzalez B.J.: PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis. Eur J Neurosci 2002, 15, 1451-1460.
  • 31. Vaudry D., Falluel-Morel A., Bourgault S., Basille M., Burel D., Wurtz O., Fournier A., Chow B.K.C., Hashimoto H., Galas L., Vaudry H.: Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 2009, 61, 283-357.
  • 32. Wojtkiewicz J., Gonkowski S., Bladowski M., Majewski M.: Characterization of cocaine- and amphetamine- regulated transcript -like immunoreactive (CART-LI) enteric neurons in the porcine small intestine. Acta Vet Hung 2012, 60, 371-381.
  • 33. Wojtkiewicz J., Równiak M., Crayton R., Gonkowski S., Robak A., Zalecki M., Majewski M., Klimaschewski L.: Axotomy - induced changes in the chemical coding pattern of colon projecting calbindin positive neurons in the inferior mesenteric ganglia of the pig. J Mol Neurosci 2013, DOI 10.1007/s12031- 013-0007-7.
  • 34. Wojtkiewicz J., Równiak M., Crayton R., Majewski M., Gonkowski S.: Chemical coding of zinc -enriched neurons in the intramural ganglia of the porcine jejunum. Cell Tissue Res 2012, 350, 215-223.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-8a6ddecc-edbe-46a4-83ee-7a228703a712
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.