Transporter protein and drug resistance of Trypanosoma

• Autorzy: Medina N.P. , Mingala C.N.
• Języki publikacji: EN

Abstrakty

EN

Trypanosoma infection is one of the most important infections in livestock and humans. One of the main problems of its therapeutic control and treatment is the resurgence of drug resistance. One of the most studied causes of such resistance is the function of its adenosine transporter gene. A trypanosomal gene TbAT1 from Trypanosoma brucei has been cloned in yeast to demonstrate its function in the transport of adenosine and trypanocidal agents. Drug resistant trypanosomes showed a defective TbAT1 variant; furthermore, deletion of the gene and set point mutations in the transporter gene has been demonstrated from isolates from relapse patients. The molecular understanding of the mechanism of action trypanocidal agents and function of transporter gene can lead to control of drug resistance of Trypanosomes.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2016
• Tom: 62
• Numer: 1
• Opis fizyczny: p.11–15,fig.,ref.

Twórcy

autor

Medina N.P.

• College of Veterinary Science and Medicine, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines

autor

Mingala C.N.

• Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz 3120, Nueva Ecija, Philippines
• Department of Animal Science, Affiliate Faculty, College of Agriculture, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines

Identyfikatory

DOI

10.17420/ap6201.26