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2011 | 20 | 1 |

Tytuł artykułu

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP - producing neurons but through the corticosterone releasing hormone (CRH) - expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitoneal-injected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelin-induced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day- old broiler chickens. These results indicate that the peripheral ghrelin - induced anorexia is caused by the stimulation of HPA axis in chickens.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

20

Numer

1

Opis fizyczny

p.118-130,fig.,ref.

Twórcy

autor
  • Department of Animal Physiology and Endocrinology, University of Agriculture of Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland
autor

Bibliografia

  • Ahmed S., Harvey S., 2002. Ghrelin: a hypothalamic GH – releasing factor in domestic fowl (Gallus domesticus). J. Endocrinol. 172, 117-125
  • Baudet M.L., Harvey S., 2003. Ghrelin – induced GH secretion in domestic fowl in vivo and n vitro. J. Endocrinol. 179, 97-105
  • Chen C.Y., Inui A., Asakawa A., Fujino K., Kato I., Chen C.C., Ueno N., Fujimiya M., 2005. Des - acylghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 129, 8-25
  • Chomczynski P., Sacchi N., 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
  • Geelissen S.M., Swennen Q., Geyten S.V., Kühn E.R., Kaiya H., Kangawa K., Decuypere E., Buyse J., Darras V.M.. 2006. Peripheral ghrelin reduces food intake and respiratory quotient in chicken. Domest. Anim. Endocrinol. 30, 108-116
  • Kaiya H., van der Geyten S., Kojima M., Hosoda H., Kitajima Y., Matsumoto M., Geelissen S., Darras V.M. Kangawa K., 2002. Chicken ghrelin: purification cDNA cloning and biological activity. Endocrinology 143, 3454-3463
  • Kaiya H., Saito E.S., Tachibana T., Furuse M., Kangawa K., 2007. Changes in ghrelin levels of plasma and proventriculus and ghrelin mRNA of proventriculus in fasted and refed layer chicks. Domest. Anim. Endocrinol. 32, 447-259
  • Khan M.S.I., Dodo K., Yahata K., Nishimoto S., Ueda H., Taneike T., Kitazawa T., Hosaka Y., Bungo T., 2006. Intracerebroventricular administration of growth hormone releasing peptide – 6 (GHRP - 6) inhibits food intake, but not food retention of crop and stomach in neonatal chicks. J. Poultry Sci. 43, 35-40
  • Kojima M., Hosoda H., Date Y., Nakazato M., Matuso H., Kangawa K., 1999. Ghrelin is a growth - hormone releasing acylated peptide from stomach. Nature 402, 656-660
  • Kojima M., Kangawa K., 2005. Ghrelin: structure and function. Physiol. Rev. 85, 495-522
  • Korbonits M., Goldstone A.P., Gueorguiev M., Grossman A.B., 2004. Ghrelin--a hormone with multiple functions. Front. Neuroendocrinol. 25, 27-68
  • Nie Q., Zeng H., Lei M., Oshag N.A., Fang M., Sun B., Yang G., Zhang X., 2004. Genomic organisation of the chicken ghrelin gene and its single nucleotide polymorphisms detected by denaturing high-performance liquid chromatography. Brit. Poultry Sci. 45, 611–618
  • Richards M.P., 2003. Genetic regulation of feed intake and energy balance in poultry. Poultry Sci. 82, 907-916
  • Richards M.P., McMurtry J.P., 2010. The avian proghrelin system. Int. J. Peptides 10, 401-414
  • Saito E.S., Kaiya H., Tachibana T., Tomonaga S., Denbow D.M., Kangawa K., Furuse M., 2005. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin - releasing factor system in neoatal chicks. Regul. Peptides 125, 201-208
  • Saito E.S., Takagi T., Nakanishi T., Sashihara K., Furuse M., 2002. Ghrelin activates behavior of neonatal chicks in a short period of post – intracerebroventricular injection. J. Appl. Anim. Res. 22, 33- 41
  • Shousha S., Nakahara K., Kojima M., Miyazato M., Hosoda H., Kangawa K., Murakami N., 2005. Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail. Gen. Comp. Endocrinol. 141, 178-183
  • Tamura H., Kamegai J., Sugihara H., Kineman R.D., Frohman L.A., Wakabayashi I., 2000. Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression. J. Neuroendocrinol. 12, 481-485
  • Toshinai K., Mondal M.S., Nakazato M., Date Y., Murakami N., Kojima M., Kangawa K., Matsukura S., 2001. Upregulation of ghrelin expression in the stomach upon fasting, insulin – induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Commun. 281, 1220-1225
  • Wang X., Day J.R., Vasilatos-Younken R., 2001. The distribution of neuropeptide Y gene expression in the chicken brain. Mol. Cell. Endocrinol. 174, 129-136
  • Zhou W., Murakami M., Hasegawa S., Yoshizawa F., Sugahara K., 2005. Neuropeptide Y content in the hypothalamic paraventricular nucleus responds to fasting and refeeding in broiler chickens. Comp. Biochem. Physiol. Pty. A 141, 146-152

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Bibliografia

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