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2004 | 13 | Suppl.2, Part 1 |
Tytuł artykułu

A comparison of Bcl-2 expression, microvessel density and color Doppler sonography in the benign and malignant ovarian tumors

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
To compare Color Doppler sonography with immunohistochemical microvessel density and Bcl-2 assessement in women with benign and malignant adnexal tumors we examined 112 women with adnexal tumors with the use color Doppler sonography (B&K 2002 ADI and GE Voluson 730 scanners) performed before the surgical procedure. Histological type, grading, FIGO stage and menopausal status were compared with MVD and Bcl-2 expression assessed with immunohistochemistry on parafín embedded tumor specimens. Results: Sixty-seven tumors were benign and 45 tumors were malignant. The mean age of the studied women was 40,4 years; ±SD, 11,5 years. Color Doppler sonography revealed that in most malignant tumors there was a low resistance to flow (mean PI= 0,56, SD=0,36). Benign tumors also had higher pulsatility indices than malignant tumors (PI=1,21 and SD=0,48; p=0,02, Mann-Whitney U-test). Also, there was a statistically significant difference between MVD in benign and malignant tumors (Mann-Whitney U test, PO.OO 1). No significant difference in the percentage of Bcl-2 stained cells in both malignant and benign tumor samples was found. Conclusion: Microvessel density assessed with CD-34 and color Doppler blood flow assessement are useful in ovarian tumors vascularity studies. Bcl-2 expression is probably not a useful marker of angiogenic tumor character.
Wydawca
-
Rocznik
Tom
13
Opis fizyczny
s.89-92,fig.,ref.
Twórcy
  • Department of Clinical Immunology, Medical University in Lublin, Lublin, Poland
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Bibliografia
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.dl-catalog-f67edee2-e685-493b-ba84-bb03da45549b
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