Biochemical targets affected by subacute doses of new pesticide mixtures tested on albino rats

• Autorzy: Shalaby S.E.M. , El-Mageed A. E. M. A.

Warianty tytułu

PL

Wpływ podostrych dawek nowych mieszanin pestycydów na przemiany biochemiczne u szczurów albinosów

• Języki publikacji: EN

Abstrakty

EN

Few studies have characterize the toxicological effects of exposure to pesticide mixtures. For this reason, the present study aimed to estimate the median lethal doses (LD50) of some new pesticide mixtures; chlorosan, feroban, cygron, engeo and kingbo on albino rats. The in vivo effect of these compounds on some biochemical targets were also investigated. The estimated median lethal doses (LD50) of chlorosan, feroban, engeo and cygron were 140.8, 264.0, 281.5 and 352.0 mg/kg body weight (b.w.), respectively. The estimated median lethal dose was more than 160.0 mg/kg b.w. in the case of kingbo. The symptoms of the affected animals included salivation, bleeding, activity increase and the chlorosan treated rats closed their eyes. Some animals died after doses of chlorosan, feroban and engeo administered at different intervals. The results showed a significant increase in the activities of plasma transaminases [Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT)] and glutathione S-transferase (GST). It was found that the tested pesticides significantly inhibited acetylcholinesterase (AChE) activity 1 h after the last dose. Also, there was a significant increase in creatinine and urea levels. The obtained data concluded that chlorosan was the most effective against albino rats followed by feroban and engeo, while kingbo was the least effective. By the end of the experiment, the enzyme activities and kidney functions of animals treated with chlorosan, feroban and engeo did not return to normal.

PL

Z przeglądu literatury wynika, że doniesienia na temat zagrożenia toksycznym działaniem pestycydów są na ogół sporadyczne. Celem prezentowanych badań było ustalenie średniej dawki letalnej (LD50) wybranych nowych mieszanin pestycydów: chlorosan, feroban, cytron, engeo i kingbo dla szczura białego. Prowadzono również badania in vivo nad wpływem pestycydów na niektóre przemiany biochemiczne w organizmie testowanych zwierząt. Ustalone średnie dawki letalne następujących pestycydów: chlorosan, feroban, engeo i cytron wynosiły odpowiednio 140,8, 264,0, 281,5 i 352,0 mg/kg masy ciała. W przypadku preparatu kingbo ustalona średnia dawka letalna przekraczała 160 mg/kg masy ciała szczura. U zwierząt poddanych działaniu pestycydów stwierdzono symptomy nadmiernego wydzielania śliny, krwawienie wzmożoną aktywność ruchową, a szczury potraktowane pestycydem kingbo miały zamknięte oczy. Odnotowano również zgon niektórych zwierząt po zastosowaniu dawek pestycydów: chlorosan, feroban, i engeo w różnych odstępach czasu. Wyniki badań wykazały istotny wzrost aktywności transaminaz cytoplazmy (GOT &GTP) i S-transferazy glutationu (GTS). Stwierdzono, że badane pestycydy wyraźnie hamowały acetylocholinesterazy (AChE) po upływie 1 godziny od zastosowania ostatniej dawki. Ponadto u testowanych szczurów wystąpił silny wzrost poziomu kreatyniny i mocznika. Na podstawie uzyskanych wyników wyciągnięto wniosek, że pestycyd chlorosan w największym stopniu wpływał na białe szczury, a dalszej kolejności preparaty feroban i engeo, natomiast pestycyd Kingo wykazał najsłabsze działanie. Do czasu zakończenia doświadczenia aktywność enzymów i czynności nerek u zwierząt potraktowanych pestycydami chlorosan, feroban i engeo nie powróciły do normalnego stanu.

Słowa kluczowe

EN

biochemical target; subacute dose; new pesticide; pesticide mixture; toxicity; rat; albino rat

• Wydawca: -
• Czasopismo: Journal of Plant Protection Research
• Rocznik: 2010
• Tom: 50
• Numer: 4
• Opis fizyczny: p.513-519,fig.,ref.

Twórcy

autor

Shalaby S.E.M.

• Pestes and Plant Protection Department, National Research Centre, Dokki, Giza, Egypt

autor

El-Mageed A. E. M. A.

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