Molekularne aspekty interakcji plemnika z oocytem u ssaków

• Autorzy: Kempisty B. , Bukowska D. , Wozna M. , Sikora J. , Jaskowski J.M.

Warianty tytułu

EN

Molecular aspects of sperm-egg fusion in mammals

• Języki publikacji: PL

Abstrakty

EN

The process of spermegg fusion is one of the most important mechanisms involved in successful fertilization. Studies conducted in an effort to elucidate this process are mainly focused on analyzing the interaction between the membrane proteins of male and female gametes. In the last few years, the genes coding proteins which may play an integral role in the process of sperm-egg binding and fusion have been identified. It has been suggested that sperm ADAMs family proteins are involved in this process. The sperm specific fertilin α, fertilin β and cyritestin are among this protein family. The oocyte’s integrins, which are included in egg cell membrane, form receptors specific for those proteins. The other group of proteins, which are connected with sperm-egg fusion, are specific for oocyte CD9 protein and sperm epididymal protein DE. The aim of this review was to present the characteristics of several proteins involved in the sperm-egg interaction process. The exploration of fertilization mechanisms may become the basic element that will improve assisted reproductive techniques and in vitro fertilization in mammals.

Słowa kluczowe

PL

aspekty molekularne; bialka ADAM; bialko CD9; bialko DE; integryny; interakcje plemnik-oocyt; rozrod zwierzat; ssaki; zaplodnienie

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 08
• Opis fizyczny: s.544-546,bibliogr

Twórcy

autor

Kempisty B.

• Katedra i Zakład Histologii i Embriologii, Wydział Lekarski II, Uniwersytet Medyczny w Poznaniu, ul.Święcickiego 6, 60-781 Poznań

autor

Bukowska D.

autor

Wozna M.

autor

Sikora J.

autor

Jaskowski J.M.

Bibliografia

• 1. Abou-Haila A., Tulsiani D. R.: Mammalian sperm acrosome: formation, contents, and function. Arch. Biochem. Biophys. 2000, 379, 173-182.
• 2. Almeida E. A., Huovila A. P., Sutherland A. E., Stephens L. E., Calarco P. G., Shaw L. M., Mercurio A. M., Sonnenberg A., Primakoff P., Myles D. G., White J. M.: Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Cell 1995, 81, 1095-1104.
• 3. Bedford J. M., Moore H. D., Franklin L. E.: Significance of the equatorial segment of the acrosome of the spermatozoon in eutherian mammals. Exp. Cell. Res. 1979, 119, 119-126.
• 4. Blobel C. P., Wolfsberg T. G., Turck C. W., Myles D. G., Primakoff P., White J. M.: A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 1992, 356, 248-252.
• 5. Boucheix C., Benoit P., Frachet P, Billard M., Worthington R. E., Gagnon J., Uzan G.: Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J. Biol. Chem. 1991, 266, 117-122.
• 6. Boucheix C., Rubinstein E.: Tetraspanins. Cell. Mol. Life Sci. 2001, 58, 1189-1205.
• 7. Chen H., Sampson N. S.: Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta. Chem. Biol. 1999, 6, 1-10.
• 8. Cho C., Bunch D. O., Faure J. E., Goulding E. H., Eddy E. M., Primakoff P., Myles D. G.: Fertilization defects in sperm from mice lacking fertilin beta. Science 1998, 281, 1857-1859.
• 9. Cuasnicu P. S., Gonzalez Echeverria F. M., Piazza A. D., Cameo M. S., Blaquier J. A.: Antibodies against epididymal glycoproteins block fertilizing ability in rat. J. Reprod. Fertil. 1984, 72, 467-471.
• 10. Evans J. P., Kopf G. S., Schultz R. M.: Characterization of the binding of recombinant mouse sperm fertilin beta subunit to mouse eggs: evidence for adhesive activity via an egg beta1 integrin-mediated interaction. Dev. Biol. 1997, 187, 79-93.
• 11. Evans J. P., Schultz R. M., Kopf G. S.: Characterization of the binding of recombinant mouse sperm fertilin alpha subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding. Dev. Biol. 1997, 187, 94-106.
• 12. He Z. Y., Brakebusch C., Fassler R., Kreidberg J. A., Primakoff P., Myles D. G.: None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev. Biol. 2003, 254, 226-237.
• 13. Kaji K., Oda S., Miyazaki S., Kudo A.: Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion. Dev. Biol. 2002, 247, 327-334.
• 14. Kaji K., Oda S., Shikano T., Ohnuki T., Uematsu Y., Sakagami J., Tada N., Miyazaki S., Kudo A.: The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat. Genet. 2000, 24, 279-282.
• 15. Kohane A. C., Cameo M. S., Pineiro L., Garberi J. C., Blaquier J. A. et al.: Distribution and site of production of specific proteins in the rat epididymis. Biol. Reprod. 1980, 23, 181-187.
• 16. Kohane A. C., Gonzalez Echeverria F. M., Pineiro L., Blaquier J. A.: Interaction of proteins of epididymal origin with spermatozoa. Biol. Reprod. 1980, 23, 737-742.
• 17. Le Naour F., Rubinstein E., Jasmin C., Prenant M., Boucheix C.: Severely reduced female fertility in CD9-deficient mice. Science 2000, 287, 319-321.
• 18. Longo F. J., Chen D. Y.: Development of surface polarity in mouse eggs. Scan. Electron. Microsc. 1984, 2, 703-716.
• 19. Miller B. J., Georges-Labouesse E., Primakoff P., Myles D. G.: Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent. J. Cell. Biol. 2000, 149, 1289-1296.
• 20. Miyado K., Yamada G., Yamada S., Hasuwa H., Nakamura Y., Ryu F., Suzuki K., Kosai K., Inoue K., Ogura A., Okabe M., Mekada E.: Requirement of CD9 on the egg plasma membrane for fertilization. Science 2000, 287, 321-324.
• 21. Nishimura H., Cho C., Branciforte D. R., Myles D. G., Primakoff P.: Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta. Dev. Biol. 2001, 233, 204-213.
• 22. Parseval A. de, Lerner D. L., Borrow P., Willett B. J., Elder J. H.: Blocking of feline immunodeficiency virus infection by a monoclonal antibody to CD9 is via inhibition of virus release rather than interference with receptor binding. J. Virol. 1997, 71, 5742-5749.
• 23. Rochwerger L., Cohen D. J., Cuasnicu P. S.: Mammalian sperm-egg fusion: the rat egg has complementary sites for a sperm protein that mediates gamete fusion. Dev. Biol. 1992, 153, 83-90.
• 24. Rochwerger L., Cuasnicu P. S.: Redistribution of a rat sperm epididymal glycoprotein after in vitro and in vivo capacitation. Mol. Reprod. Dev. 1992, 31, 34-41.
• 25. Seigneuret M., Delaguillaumie A., Lagaudriere-Gesbert C., Conjeaud H.: Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. J. Biol. Chem. 2001, 276, 40055-40064.
• 26. Tachibana I., Hemler M. E.: Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance. J. Cell Biol. 1999, 146, 893-904.
• 27. Takahashi Y., Yamakawa N., Matsumoto K., Toyoda Y., Furukawa K., Sato E.: Analysis of the role of egg integrins in sperm-egg binding and fusion. Mol. Reprod. Dev. 2000, 56, 412-423.
• 28. Wong G. E., Zhu X., Prater C. E., Oh E., Evans J. P.: Analysis of fertilin alpha (ADAM1)-mediated sperm-egg cell adhesion during fertilization and identification of an adhesion-mediating sequence in the disintegrin-like domain. J. Biol. Chem. 2001, 276, 24937-24945.
• 29. Yanagimachi R., Yanagimachi H., Rogers B. J.: The use of zona-free animal ova as a test-system for the assessment of the fertilizing capacity of human spermatozoa. Biol. Reprod. 1976, 15, 471-476.
• 30. Zhu G. Z., Miller B. J., Boucheix C., Rubinstein E., Liu C. C., Hynes R. O., Myles D. G., Primakoff P.: Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion. Development 2002, 129, 1995-2002.
• 31. Zhu X., Evans J. P.: Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane. Biol. Reprod. 2002, 66, 1193-1202.

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