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2010 | 66 | 07 |

Tytuł artykułu

Wirus zapalenia wątroby typu A (HAV) - czynnik etiologiczny infekcji pokarmowych człowieka

Warianty tytułu

EN
Hepatitis A virus (HAV): an etiological agent of food borne human infection

Języki publikacji

PL

Abstrakty

EN
Hepatitis A virus (HAV) is the most common cause of hepatitis in humans all over the world. Non-enveloped HAV is classified to the Picornaviridae family. The virus is highly resistant to physico-chemical factors. The genome contains the single-strand RNA encoding a long polyprotein. This polyprotein is used to form four structural and seven non-structural proteins in the post translating process. All polyprotein cleavage sites have not been identified, yet infection with HAV frequently occurs through the consumption of contaminated food or water. The disease is often asymptomatic in young children. In older children and adults different clinical symptoms may be observed, from mild (without jaundice) to severe liver failure. In many regions of the world the disease occurs endemically and in developed countries outbreaks and epidemics are noted. Inactivated vaccines are used in specific protection.

Wydawca

-

Rocznik

Tom

66

Numer

07

Opis fizyczny

s.439-443,rys.,fot.,tab.,bibliogr.

Twórcy

autor
  • Zakład Wirusologii Żywności i Środowiska, Państwy Instytut Weterynaryjny - Państwowy Instytut Badawczy, Al. Partyzantów 57, 24-100 Puławy

Bibliografia

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  • 12.Feinstone S. M., Kapikian A. Z., Purcell R. H.: Hepatitis A: detection by immune electron microscopy of a virus-like antigen associated with acute illness. Science 1973, 182, 1026-1028.
  • 13.Fiore A. E., Wasley A., Bell B. P.: Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2006, 55, RR-7.
  • 14.García-Aguirre L., Cristina J.: Analysis of the full-length genome of hepatitis A virus isolated in South America: heterogeneity and evolutionary constraints. Arch. Vir. 2008, 153, 1473-1478.
  • 15.Harmon S. A., Richards O. C., Summers D. F., Ehrenfeld E.: The 5'-terminal nucleotides of hepatitis A virus RNA, but not poliovirus RNA, are required for infectivity. J. Virol. 1991, 65, 2757-2760.
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  • 17.Knipe D. M., Howley P. M.: Fields Virology. T. 2, Philadelphia, USA 2007, 911-940.
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  • 21.Magdzik W.: Wirusowe zapalenie w¹troby typu A (wzw A) w 2003 roku. Przegl. Epidemiol. 2005, 59, 289-295.
  • 22.Martin A., Lemon S. M.: Hepatitis A virus: from discovery to vaccines. Hepatology 2006, 43, 164-172.
  • 23.Morace G., Kusov Y., Dzagurov G., Beneduce F., Gauss-Müller V.: The unique role of domain 2A of the hepatitis A virusprecursor polypeptide P1-2A in viral morphogenesis. BMB, Rep. 2008, 41, 678-683.
  • 24.Mrozińska M., Miksa G.: Wirusowe zapalenie wątroby typu A - nowoczesna, skuteczna, bezpieczna metoda zwalczania epidemii wzw A. Przew. Lek. 2002, 5, 18-20.
  • 25.Paul A. V., Rieder E., Kim D. W., Van Boom J. H., Wimmer E.: Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg. J. Virol. 2000, 74, 10359-10370.
  • 26.Peters H., Kusov Y. Y., Meyer S., Benie A. J., Bäuml E., Wolff M., Rademacher C., Peters T., Gauss-Müller V.: Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization. Biochem. J. 2005, 385, 363-370.
  • 27.Probst C., Jecht M., Gauss-Muller V.: Intrinsic signals for the assembly of hepatitis A virus particles. J. Biol. Chem. 1999, 274, 4527-4531.
  • 28.Robertson B. H., Jansen R. W., Khanna B., Totsuka A., Nainan O. V., Siegl G., Widell A., Margolis H. S., Isomura S., Ito K., Ishizu T., Moritsugu Y., Lemon S. M.: Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J. Gen. Virol. 1992, 73, 1365-1377.
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  • 33.Totsuka A., Moritsugu Y.: Hepatitis A virus proteins. Intervirol. 1999, 42, 63-68.
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  • 35.Zhang H., Chao S. F., Ping L. H., Grace K., Clarke B., Lemon S. M.: An infectious cDNA clone of a cytopathic hepatitis A virus: Genomic regions associated with rapid replication and cytopathic effect. Virol. 1995, 212, 686-697.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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