p53 protein expression in gastric cancer cells - its correlation with clinicopathological features and selected serum neoplasmatic markers
The aim of the present study was to assess the possible correlation of p53 with CEA and Ca 19-9 serum levels as well as with selected clinicopathological data. 46 patients, who were gastrectomized due to gastric cancer between 1998 and 2001, were analyzed. The concentration of CEA and Ca 19.9 was estimated in serum. Mean percentage of p53-positive cells in present group was 33,69 %. The comparison of mean percentage of p53-positive cells with IHC reaction intensity revealed statistically significant, directly proportional correlation, with p<0,001. Mean CEA and Ca 19-9 serum concentration were 1,75± 1,71 ng/ml, and 17,34±44,73 U/ml respectively. No significant correlation between p53-expression, CEA and Cal9-9 was noted respecting several clinicopathological data of tumors. However clear trend of higher CEA and Cal9-9 values in groups of potentially worse prognosis (T3-T4; Nl-2; III grade of disease) was observed.