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2011 | 55 | 3 |
Tytuł artykułu

In vitro studies of the effect of theophylline and/or N-acetylcysteine on redox homeostasis and ketogenesis in rat hepatocytes

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The examinations were conducted on hepatocvtes isolated by means of enzymatic method from the liver of three-month-old Wistar rats. The cells were incubated in medium with addition of theophylline and/or N-acetylcysteine. Significant changes in the activity of SOD, GPx, and GR in hepatocvtes incubated in the presence of the compounds in comparison with control cells demonstrated that theophylline and/or N-acetylcysteine disturb oxidative-reductive homeostasis of the cells. Changes in concentrations of ketone bodies, resulting in disturbances of acetoacetate to ß-hydroxybutyrate molar ratio, point to an unfavourable interference of theophylline into ketogenesis, which is equivalent with the disturbance of the balance between NAD⁺ and NADH+H⁺ in hepatocvtes. N-acetylcysteine simultaneously present with theophylline in incubation medium exerted a protective action on ketogenesis.
Wydawca
-
Rocznik
Tom
55
Numer
3
Opis fizyczny
p.519-524,ref.
Twórcy
autor
  • Department of Food and Nutrition, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
autor
autor
autor
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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