Infections caused by RSV among children and adults during two epidemic seasons

• Autorzy: Pancer K. , Ciacka A. , Gut W. , Lipka B. , Mierzejewska J. , Milewska-Bobula B. , Smorczewska-Kiljan A. , Jahnz-Rozyk K. , Dzierzanowska D. , Madalinski K. , Litwinska B.
• Języki publikacji: EN

Abstrakty

EN

Respiratory Syncytial Virus (RSV) is one of the most common causes of lower respiratory tract infections in young children, immunocompromised patients (children and adults), patients with chronic respiratory diseases and elderly people. Reinfections occur throughout the life, but the severity of disease decreased with subsequent infection. The aim of this study was to analyze the frequency of RSV infections in two selected subpopulations: young children (below 5 y.) and adults with chronic respiratory diseases (25–87 y.). Nasopharyngeal swabs (334) collected from October 2008 to March 2010 were examined. The presence of RSV genome was determined by RT-PCR and the presence of RSV antigen by quick immunochromatographic test. Positive results of RT-PCR were found in 45.2% of all swabs: 48.6% samples in 2008; 41.5% in 2009; 50.8% in 2010. The highest frequency of RSV-positive samples was in fall-winter months, but differences in RSV epidemic seasons were found. In the first season (2008–2009) an increased number of RSV infections was observed from November 2008, but in the second season – from January 2010. Generally, the frequency of RSV-positive RT-PCR among children was 53%, among adults 25%. The highest difference was observed in the first three-month period of 2010. RT-PCR positive samples were found in 68.5% of children and 5.9% of adults. However, the RSV antigen was found in 44.4% of samples collected from adults in this period. Our results indicate that the contribution of RSV infections during epidemic season of respiratory tract infections in Poland was really high among children and adults.

Słowa kluczowe

EN

epidemic season; child; infection; high-risk group; respiratory syncytial virus; risk group; Paramyxoviridae; RSV zob.respiratory syncytial virus; infant; respiratory tract infection

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2011
• Tom: 60
• Numer: 3
• Opis fizyczny: p.253-258,fig.,ref.

Twórcy

autor

Pancer K.

• Department of Virology, National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland

autor

Ciacka A.

autor

Gut W.

autor

Lipka B.

autor

Mierzejewska J.

autor

Milewska-Bobula B.

autor

Smorczewska-Kiljan A.

autor

Jahnz-Rozyk K.

autor

Dzierzanowska D.

autor

Madalinski K.

autor

Litwinska B.

Bibliografia

• Belino-Studzińska P. and Pancer K. 2008. Respiratory syncytial virus: as an etiological agent of respiratory tract infection in children and adults (in Polish). Przegl. Epidemiol. 62: 767–75.
• Black C.P. 2003. Systematic review of the biology and medical management of Respiratory syncytial virus infection. Respiratory Care 48: 209–233.
• Calvo C., F. Pozo, M.L. Garcia-Garcia, M. Sanchez, M. Lopez-Valero, P. Pérez-Breña and I. Casas. 2010. Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study. Acta Paediatr. 99: 883–887.
• Dowell S.F., L.J. Anderson, H.E. Jr Gary, D.D. Erdman, J.F. Plouffe, T.M. Jr File, B.J. Marston and R.F. Breiman. 1996. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J. Infect. Dis. 174: 456–462.
• Falsey A.R., P.A. Hennessey, M.A. Formica, M.S.C. Cox and E.E. Walsh. 2005. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352: 1749–1759.
• Falsey A.R., J.J. Treanor, R.F. Betts and E.E. Walsh. 1992. Viral respiratory infections in the institutionalized elderly: clinical and epidemiological findings. J. Am. Geriatr. Soc. 40: 115–119.
• Fjaerli H.O., T. Farstad and D. Bratlid. 2004. Hospitalizations for Respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993–2000: a population-based retrospective study. BMC Pediatric 4: 25–31.
• Hashem M. and C.B. Hall. 2003. Respiratory syncytial virus in healthy adults: the cost of cold. J. Clin. Virol. 27: 14–21.
• Iwane M.K., K.M. Edwards, P.G. Szilagyi, S.G. Humiston, R. Barth, T. McInerny, L. Shone and B. Schwartz. 2004. Population-based surveillance for hospitalizations associated with Respiratory syncytial virus, Influenza virus, and Parainfluenza viruses among young children. Pediatrics 113: 1758–1764 updated 2010: http://www.pediatrics.org/cgi/content/full/113/6/1758.
• Jaguś P., J. Chorostowska-Wynimko and A. Roży. 2010. Diagnostics of some viral infections of respiratory tract (in Polish). Pneumonol. Alergol. Pol. 78: 47–53.
• Krilov L.R. Respiratory Syncytial Virus (RSV) infection. eMedicine Pediatrics. http://emedicine.medscape.com/article/971488.
• Lamb R.A. and G.D. Parks. 2007. Paramyxoviridae. The Viruses and their Replication. pp. 1449–1496 In: Knipe D.M, Howley P.M (eds.) Fields of virology Lippincott Williams& Wilkins, Wolters Kluwer Business.
• Łuczak G., E. Kozielska, J. Tyl, A. Borkowska, A. Galińska, W. Radys and Z. Bohdan. 2003. Role of Respiratory syncytial virus in respiratory tract infections pathogenesis in infants and small children. Med. Sci. Monit. 9: 44–47.
• Mahony J.B. 2008. Detection of respiratory viruses by molecular methods. Clin. Microbiol. Rev. 21: 716–747
• Mills J.M., J. Harper, D. Broomfield and K.E. Templeton. 2010. Rapid testing for Respiratory syncytial virus in a pediatric emergency department: benefits for infection control and bed management. J. Hosp. Infect. doi:10.1016/j.jhin.2010.11.019
• Mlinaric-Galinovic G., R.C. Wellver, T. Vilibic-Cavlek, S. Ljubin-Sternak, V. Drazenovic, I. Galinovic and V. Tomic. 2008. The biennial cycle of Respiratory syncytial virus outbreaks in Croatia. Virology Journal. 5: 18–23.
• Murata Y. and A.R. Falsey. 2007. Respiratory syncytial virus infection in adults. Antivir. Ther. 12: 659–670.
• Nair H., D.J. Nokes, B.D. Gessner, M. Dherani, S.A. Madhi, R.J. Singleton, K.L. O’Brien, A. Roca, P.F. Wright, N. Bruce and others. 2010. Global burden of acute lower respiratory infections due to Respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375: 1545–1555.
• Olsen S.J., S. Thamthitiwat, S. Chandra, M. Chittaganpitch, A.M. Fry, J.M. Simmerman, H.C. Baggett, T.C. Peret, D. Erdman, R. Benson and others. 2010. Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand. Epidemiol. Infect. 21: 1–12.
• Pancer K., A. Panasik, W. Gut, B. Lipka, D. Puchta, B. Milewska-Bobula, D. Dzierżanowska and B. Litwińska. 2010a. Infections caused by RSV – problems of diagnostic based on serological examinations. pp. 115–122. In: M. Polz-Dacewicz (ed.) Viral Infectiondiagnostics, prevention and control. The role of viral infection in public health. Uniwersytet Medyczny w Lublinie, Polskie Towarzystwo Wirusologiczne, DA Studio
• Pancer K., A. Panasik, A. Makówka, P. Belino-Studzińska, W. Gut, D. Puchta, D. Dzierżanowska and B. Litwińska. 2010b. The influence of preanalytical factors on detection of RNA viruses by reverse transcription – polymerase chain reaction (RT-PCR). pp. 105–113. In: M. Polz-Dacewicz (ed.) Viral Infection-diagnostics, prevention and control. The role of viral infection in public health. Uniwersytet Medyczny w Lublinie, Polskie Towarzystwo Wirusologiczne, DA Studio.
• Roca A., M.P. Loscertales, L. Quintó, P. Pérez-Breña, N. Vaz, P.L. Alonso and J.C. Saiz. 2001. Genetic variability among group A and B Respiratory syncytial viruses in Mozambique: identification of a new cluster of group B isolates. J. Gen. Virol. 82: 103–11.
• Schutzle H., J. Weigl, W. Puppe, J. Forster and R. Berner. 2008. Diagnostic performance of a rapid antigen test for RSV in comparison with a 19-valent multiplex RT-PCR ELISA in children with acute respiratory tract infections. Eur. J. Pediatr. 167: 745–749.
• Sullender W.M. 2000. Respiratory syncytial virus genetic and antigenic diversity. Clin. Microbiol. Rew. 13: 1–15.
• Światły A. 2001. Acute bronchitis (in Polish). Przew Lek. 4: 6, 89–91.
• Tranda I., J. Wilczyński, M. Wróblewska-Kałużewska and E. Torbicka. 2000. Epidemiology of respiratory tract acute viral infections in children during first two years (in Polish). Ped. Pol. 75: 619–623.