The effects of polymorphisms in DGAT1, GH and GHR genes on reproduction and production traits in Jersey cows

• Autorzy: Komisarek J. , Michalak A. , Walendowska A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to examine the impact of four single nucleotide polymorphisms in DGAT1, GH and GHR genes on reproduction, production and udder health in Jersey cattle. The study was conducted on 209 cows from the Polish active dairy population and genotypes were identified using the PCR-RFLP technique. The significant effects on certain of analysed traits were revealed of GHL127V and GHR-F279Y polymorphisms. Replacement of the phenylalanine encoding T allele by the tyrosine encoding A variant at GHR-F279Y locus led to decrease in milk, fat and protein yields. The GH-L127V-CC genotype was found to be significantly associated with the shorter calving interval and shorter interval from calving to conception than the other two GH genotypes. No relations were found between DGAT1-K232A mutation and health or reproductive traits of cows.

Słowa kluczowe

EN

polymorphism; DGAT1 gene; gene polymorphism; gene; reproduction trait; production trait; Jersey breed; cow

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2011
• Tom: 29
• Numer: 1
• Opis fizyczny: p.29-36,ref.

Twórcy

autor

Komisarek J.

• Department of Cattle Breeding and Milk Production, Poznan University of Life Sciences, Wojska Polskiego 71 A, 60-625 Poznan, Poland

autor

Michalak A.

autor

Walendowska A.

Bibliografia

• BALOGH O., KOVÁCS K., KULCSÁR M., GÁSPÁRDY A., ZSOLNAI A., KÁTAI L., PÉCSI A.,FÉSÜS L., BUTLER W.R., HUSZENICZA G., 2009 – AluI polymorphism of the bovine growth hormone (GH) gene, resumption of ovarian cyclicity, milk production and loss of body condition at the onset of lactation in dairy cows. Theriogenology 71, 553-559.
• BLOTT S., KIM J.J., MOISIO S., SCHMIDT-KÜNTZEL A., CORNET A., BERZI P., CAMBISANO N., FORD C., GRISART B., JOHNSON D., KARIM L., SIMON P., SNELL R., SPELMAN R.,WONG J., VILKKI J., GEORGES M., FARNIR F., COPPIETERS W., 2003 – Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.Genetics 163, 253-266.
• DISKIN M.G., MACKEY D.R., ROCHE J.F., SREENAN J.M., 2003 – Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Animal Reproduction Science 78, 345-370.
• ETGEN A.M., GONZÁLEZ-FLORES O., TODD B.J., 2006 - The role of insulin-like growth factor-I and growth factor-associated signal transduction pathways in estradiol and progesterone facilitation of female reproductive behaviors. Frontiers in Neuroendocrinology 27, 363-375.
• ETHERTON T.D., 2004 – Somatotropic function: the somatomedin hypothesis revisited. Journal of Animal Science 82, E239-244.
• FARESE JR R.V., CASES S., SMITH S.J., 2000 – Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase. Current Opinion in Lipidology 11, 229-234.
• GE W., DAVIS M.E., HINES H.C., IRVIN K.M., 1999 – Two-allelic DGGE polymorphism detected in the promoter region of the bovine GHR gene. Animal Genetics 30, 71.
• GRISART B., COPPIETERS W., FARNIR F., KARIM L., FORD C., BERZI P., CAMBISANO N.,MNI M., REID S., SIMON P., SPELMAN R., GEORGES M., SNELL R., 2002 – Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Research 12, 222-231.
• GROCHOWSKA R., SORENSEN P., ZWIERZCHOWSKI L., SNOCHOWSKI M., LOVENDAHL P.J., 2001 – Genetic variation in stimulated GH release and in IGF-I of young dairy cattle and their associations with the leucine/valine polymorphism in the GH gene. Journal of Animal Science 79,470-476.
• KATOH K., KOUNO S., OKAZAKI A., SUZUKI K., OBARA Y., 2008 – Interaction of GH polymorphism with body weight and endocrine functions in Japanese black calves. Domestic Animal Endocrinology 34, 25-30.
• KAUPE B., BRANDT H., PRINZENBERG E.M., ERHARDT G., 2007 – Joint analysis of the influence of CYP11B1 and DGAT1 genetic variation on milk production, somatic cell score,conformation, reproduction, and productive lifespan in German Holstein cattle. Journal of Animal Science 85, 11-21.
• KOMISAREK J., MICHALAK A., 2008 – A relationship between DGAT1 K232A polymorphism and selected reproductive traits in Polish Holstein-Friesian cattle. Animal Science Papers and Reports 26, 89-95.
• KOMISAREK J., WAŚKOWICZ K., MICHALAK A., DORYNEK Z., 2004 – Effects of DGAT1 variants on milk production traits in Jersey cattle. Animal Science Papers and Reports 22, 307-313.
• KOVÁCS K., VÖLGYI-CSÍK J., ZSOLNAI A., GYÖRKÖS I., FÉSÜS L., 2006 – Associations between the AluI polymorphism of growth hormone gene and production and reproduction traits in a Hungarian Holstein-Friesian bull dam population. Archives of Animal Breeding 49, 236-249.
• LUCY M.C., HAUSER S.D., EPPARD P.J., KRIVI G.G., CLARK J.H., BAUMAN D.E., COLLIER R.J., 1993 – Variants of somatotropin in cattle: gene frequencies in major dairy breeds and associated milk production. Domestic Animal Endocrinology 10, 325-333.
• NÄSLUND J., FIKSE W.F., PIELBERG G.R., LUNDÉN A., 2008 – Frequency and effect of the bovine acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism in Swedish dairy cattle. Journal of Dairy Science 91, 2127-2134.
• OIKONOMOU G., ANGELOPOULOU K., ARSENOS G., ZYGOYIANNIS D., BANOS G., 2009 – The effects of polymorphisms in the DGAT1, leptin and growth hormone receptor gene loci on body energy, blood metabolic and reproductive traits of Holstein cows. Animal Genetics 40, 10-17.
• REIST M., ERDIN D.K., VON EUW D., TSCHÜMPERLIN K.M., LEUENBERGER H., HAMMON H.M., MOREL C., PHILIPONA C., ZBINDEN Y., KÜNZI N., BLUM J.W., 2003 – Postpartum reproductive function: association with energy, metabolic and endocrine status in high yielding dairy cows. Theriogenology 59, 1707-1723.
• SANDERS K., BENNEWITZ J., REINSCH N., THALLER G., PRINZENBERG E.-M., KÜHN C., KALM E., 2006 – Characterization of the DGAT1 mutations and the CSN1S1 promoter in the German Angeln dairy cattle population. Journal of Dairy Science 89, 3164-3174.
• SEAVEY B.K., SINGH R.N., LEWIS U.J., GESCHWIND I.I., 1971 - Bovine growth hormone:evidence for two allelic forms. Biochemical and Biophysical Research Communications 43, 189-195.
• SORENSEN P., GROCHOWSKA R., HOLM L., HENRYON M., LOVENDAHL P., 2002 –Polymorphism in the bovine growth hormone gene affects endocrine release in dairy calves. Journal of Dairy Science 85, 1887-1893.
• SPELMAN R.J., FORD C.A., MCELHINNEY P., GREGORY G.C., SNELL R.G., 2002 –Characterization of the DGAT1 gene in the New Zealand dairy population. Journal of Dairy Science 85, 3514-3517.
• SUCHOCKI T., KOMISAREK J., SZYDA J., 2010 – Testing candidate gene effects on milk production traits in dairy cattle under various parameterizations and inheritance modes. Journal of Dairy Science 93, 2703-2717.
• THALLER G., KRÄMER W., WINTER A., KAUPE B., ERHARDT G., FRIES R., 2003 – Effects of DGAT1 variants on milk production traits in German cattle breeds. Journal of Animal Science 81, 1911-1918.
• VELASQUEZ M.A., SPICER L.J., WATHES D.C., 2008 – The role of endocrine insulin-like growth factor-I (IGF-I) in female bovine reproduction. Domestic Animal Endocrinology 35, 325-342.
• VIITALA S., SZYDA J., BLOTT S., SCHULMAN N., LIDAUER M., MÄKI-TANILA A.,GEORGES M., VILKKI J., 2006 – The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Ayrshire dairy cattle. Genetics 173,2151-6214.
• WATHES D.C., FENWICK M., CHENG Z., BOURNE N., LLEWELLYN S., MORRIS D.G.,KENNY D., MURPHY J., FITZPATRICK R., 2007 – Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow. Theriogenology 68, S232-41.
• WINTER A., KRÄMER W., WERNER F.A.O., KOLLERS S., KATA S., DURSTEWITZ G.,BUITKAMP J., WOMACK J.E., THALLER G., FRIES R., 2002 – Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proceedings of the National Academy of Sciences of the USA 99, 9300-9305.
• ZHU L., POLLARD J.W., 2007 – Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling. Proceedings of the National Academy of Sciences of the USA 104, 15847-15851.