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2010 | 54 | 3 |
Tytuł artykułu

Plasma level of protein C, fibrinogen concentration, and platelet number in dogs with Leg-Calve-Perthes disease and osteochondrosis. Preliminary studies

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The possible role of coagulatory disorders in pathogenesis of Legg-Calve-Perthes disease (Lepo) and osteochondrosis (OC) was examined. A decrease in protein C level in dogs with LCPD (94.31±4.74%) in comparison with healthy dogs (95.8±6.35%) was observed. Moreover, in OC affected animals, the value varied between 92.25±2.5% and 94.33±5.5%. The mean plasma fibrinogen level in control group was 2.69±0.65 mg/mL, whereas in OC groups significantly higher values were found. Platelets number varied between individuals but was within normal range in all groups. Taking into account a decrease in protein C plasma level and an increase in fibrinogen concentration, the relationship between developmental diseases and coagulation disorders was revealed in dogs.
Wydawca
-
Rocznik
Tom
54
Numer
3
Opis fizyczny
p.433-436,fig.,ref.
Twórcy
autor
  • Department and Clinic of Animal Surgery, 20-612 Lublin, Poland
Bibliografia
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  • 2. Cook W.T., Smith M.M.: Perthes' Disease. In: Textbook of Small Animal Surgery. Edited by Sanders, New York, 2003, vol. II, pp. 2260-2263.
  • 3. Gambardella P.C.: Legg-Calve-Perthes disease in dogs. In: Disease Mechanisms in Small Animal Surgery. Edited by Lea & Febiger, New York, 1993, pp. 804-807.
  • 4. Gando S., Kameue T., Matsuda N., Hayakawa M., Hoshino H., Kato H.: Serial changes in neutrophil- endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb Res 2005, 116, 91-100.
  • 5. Glueck C.J., Crawford A., Roy D., Freiberg R., Glueck H., Stroop D.: Association of antithrombic factor deficiencies and hypofibrinolysis with Legg-Perthes disease. J Bone Joint Surg 1996, 78, 3-13.
  • 6. Glueck C.J., Glueck H.I., Greenfield D., Freiberg R., Kahn A., Hamer T., Stroop D., Tracy T.: Protein C and S deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease. Pediatr Res 1994, 35, 383-388.
  • 7. Handley D.A., Hughes T.E.: Pharmacological approaches and strategies for therapeutic modulation of fibrinogen. Thromb Res 1997, 87, 1-36.
  • 8. Hegemann N., Kohn B., Brunnberg L., Schmidt M.F.: Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. Osteoarthritis Cartilage 2002, 10, 714-721.
  • 9. Herrick S., Blanc-Brude O., Gray A., Laurent G.: Fibrinogen. Internad J Biochem Cell Biol 1999, 31, 741- 746.
  • 10. Matos M.A.: The role of protein C deficiency in the etiology of Perthes disease. Ortop Traumatol Rehabil 2008, 10, 274-278.
  • 11. Murakawa M., Okamura T., Kamura T., Kuroiwa M., Harada M., Niho Y.: A comparative study of partial primary structures of the catalytic region of mammalian protein C. Br J Haematol 1994, 86, 590-600.
  • 12. Murata H., Shimada N., Yoshioka M.: Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J 2004, 168, 28-40.
  • 13. Olsson S.-E.: Pathophysiology, morphology, and clinical signs of osteochondrosis in the dog. In: Disease Mechanisms in Small Animal Surgery. Edited by Lea & Febiger, New York, 1993, pp. 777-796.
  • 14. Seguin C., Kassis J., Busque L., Bestawros A., Theodoropoulos J., Alonso M.-L., Harvey E.J.: Nontraumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia. Reumatology 2008, 47, 1151-1155.
  • 15. Wainwright A.M., Benson M.K.D.: Legg-Calve-Perthes disease. Curr Orthop 2001, 15, 127-134.
  • 16. Yilmaz D., Karapinar L., Karapinar B., Ozturk H., Kavakli K.: Evaluation of anticoagulant system in Turkish children with Perthes disease. Pediatr Int 2005, 47, 43-48.
  • 17. Yotsuyanagi S.E., Rosa N.M., Burger C.P., Moraes P.C.: Legg-Calve-Perthes disease: A retrospective study - 307. Proc 34th WSAVA Congress. Sao Paulo, 2009, p. 307.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.dl-catalog-c749e1ff-61f8-47bb-ae42-059ef984efc6
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