Impact of iridovirus and methisoprinol on immunocompetent cells isolated from African catfish, Clarias gariepinus (Burchell), under in vitro conditions

• Autorzy: Kazun B. , Siwicki A. K.

Warianty tytułu

PL

Wpływ iridowirusa oraz methisoprinolu na komórki immunokompetentne izolowane od suma afrykańskiego Clarias gariepinus (Burchell) w warunkach in vitro

• Języki publikacji: EN

Abstrakty

EN

Experiments to assess the effectiveness of the immunostimulator methisoprinol (Polfa Grodzisk Pharmaceuticals, Poland) focused on its impact on the innate immune response. The impact of different doses of methisoprinol on organ leukocytes isolated from the kidneys and spleens of African catfish that were subjected to or not subjected to the suppressive impact of iridovirus. The results indicate that the addition of methisoprinol causes increased respiratory burst activity (RBA), potential killing activity (PKA), and proliferative activity of lymphocytes T and B in response to mitogens. Methisoprinol stimulates the mechanisms of cellular immunity that are linked to the activation of T lymphocytes, which can impact the antiviral activity of this preparation after its application in vivo.

PL

Słowa kluczowe

EN

iridovirus; methisoprinol; immunocompetent cell; isolation; African catfish; Clarias gariepinus; fish; in vitro condition; immunostimulation

• Wydawca: -
• Czasopismo: Archives of Polish Fisheries
• Rocznik: 2011
• Tom: 19
• Numer: 1
• Opis fizyczny: p.31-36,fig.,ref.

Twórcy

autor

Kazun B.

• Department of Fish Pathology and Immunology, Zabieniec, Inland Fisheries Institute in Olsztyn, Glowna 48, 05-500 Zabieniec, Poland

autor

Siwicki A. K.