Komórki regulatorowe z populacji limfocytów CD4+

• Autorzy: Maslanka T.

Warianty tytułu

EN

CD4+ Regulatory cells

• Języki publikacji: PL

Abstrakty

EN

Regulatory T cells are heterogeneous with sub-populations which differ from each other in their phenotype, immune inhibitory mechanisms and function. These cells are responsible for the regulation of the immune response and play a leading role in developing immune tolerance through active suppression. Suggested functions for regulatory T cells include: prevention of autoimmune diseases by maintaining self-tolerance, oral tolerance, and, moreover, suppression of allergy and pathogen-induced immunopathology.There are two general types of the regulatory lymphocytes: natural cells, which develop in the thymus, and induced cells, which are derived from naive lymphocytes in the periphery. These cells consist of heterogeneous subsets that include CD4⁺ cells, CD8⁺ cells, γδ⁺ T cells and NK cells. The first two types of cells can be subdivided into several phenotypic groups. The present review will characterize the human and murine CD4⁺ regulatory cells, i.e., natural (nTreg) and induced (iTreg) CD4⁺CD25⁺Foxp3⁺ cells, IL-10 secreting Tr1 cells and TGF-β secreting Th3 cells. This paper focuses mainly on aspects concerning the phenotypic markers, development and functional activities of these cells, as well as their immune inhibitory mechanisms.

Słowa kluczowe

PL

komorki regulatorowe; limfocyty CD4 plus; limfocyty Foxp3; limfocyty Th3

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 12
• Opis fizyczny: s.827-832,rys.,bibliogr.

Twórcy

autor

Maslanka T.

• Katedra Farmakologii i Toksykologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Warmińsko-Mazurski w Olsztynie, ul.Oczapowskiego 13, 10-718 Olsztyn

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