Evaluation of vitamin C and vitamin B6 influence on the level of carnitine in plasma of healthy adults
Efficiency of L-carnitine endogenous biosynthesis in humans depends on the presence of cofactors of numerous enzymatic reactions. Among others, the role of cofactor is played by vitamin C and vitamin B6. The objective of our study was to evaluate the influence of vitamins C and B6 stores on plasma carnitine level in healthy humans. The examined group consisted of 52 healthy volunteers. Total (TC) and free (FC) carnitine, ascorbic acid (AA) in plasma and indices of vitamin B6 in plasma and in erythrocytes were determined. Mean TC was 52.2 ± 10.7 mmol/1 and FC 44.4 ± 9.5 mmol/1. Mean AA was 0.4 ± 0.3 mg/dl. In 40% of examined group AA levels were out of the reference range. B6 indices in plasma and erythrocytes were 1.21 ± 0.23 and 1.42 ± 0.33, respectively. Vitamin C and vitamin B6 did not influence carnitine plasma levels, that confirms the marginal role of endogenous biosynthesis in the carnitine balance in healthy subjects. Moreover, a significant distribution of vitamin C deficiency was found in the evaluated population.