AVE 0991 - angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE - knockout mice

• Autorzy: Toton-Zuranska J. , Gajda M. , Pyka-Fosciak G. , Kus K. , Pawlowska M. , Niepsuj A. , Wolkow P. , Olszanecki R. , Jawien J. , Korbut R.
• Języki publikacji: EN

Abstrakty

EN

Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by “en face” method (7.63±1.6% vs. 14.6±2.1%) and “cross-section” method (47 235±7 546 µm2 vs. 91 416±8 357 µm2). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.

Słowa kluczowe

EN

angiotensin [1-7]; apoE-knockout mice; apolipoprotein E; atherogenesis; atherosclerosis; cardiovascular system; plasma lipid; renin-angiotensin system; mice; mouse

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 2
• Opis fizyczny: p.181-183,fig.,ref.

Twórcy

autor

Toton-Zuranska J.

• Jagiellonian University Medical College, Grzegorzecka Str. 16, 31-531 Krakow, Poland

autor

Gajda M.

autor

Pyka-Fosciak G.

autor

Kus K.

autor

Pawlowska M.

autor

Niepsuj A.

autor

Wolkow P.

autor

Olszanecki R.

autor

Jawien J.

autor

Korbut R.

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