Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis

• Autorzy: Chen S.Y. , Wan L. , Huang C.M. , Huang Y.C. , Sheu J.J.C. , Lin Y.J. , Liu S.P. , Lan Y.C. , Lai C.H. , Lin C.W. , Tsai C.H. , Tsai F.J.
• Języki publikacji: EN

Abstrakty

EN

Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. A previous study indicated that a DNA repair system was involved in the development of RA. In this study, we investigated the association of four N-methylpurine-DNA glycosylase (MPG) gene polymorphisms (rs3176364, rs710079, rs2858056, and rs2541632) with susceptibility to RA in 384 Taiwanese individuals (192 RA patients and 192 control subjects). Our data show a statistically significant difference in genotype frequency distributions at rs710079 and rs2858056 SNPs between RA patients and control groups (P = 0.040 and 0.029, respectively). Our data also indicated that individuals with the GG genotype at rs2858056 SNP may have a higher risk of developing RA. In addition, compared with the haplotype frequencies between case and control groups, individuals with the GCGC haplotype appeared to be at a greater risk of RA progression (P = 0.003, OR = 1.75; 95% CI = 1.20-1.55). Our results suggest that rs710079 and rs2858056 polymorphisms and the GCGC haplotype in the MPG gene are associated with the risk of RA progression, and thus may be used as molecular markers of RA if they are confirmed by further research.

Słowa kluczowe

EN

genetic polymorphism; DNA repair gene; susceptibility; rheumatoid arthritis; N-methylpurine-DNA glycosylase; single nucleotide polymorphism; autoimmune disease; disease risk

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2010
• Tom: 51
• Numer: 4
• Opis fizyczny: p.519-521,fig.,ref.

Twórcy

autor

Chen S.Y.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Wan L.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Huang C.M.

• Division of Immunology and Rheumatology, Taichung, Taiwan

autor

Huang Y.C.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Sheu J.J.C.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Lin Y.J.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Liu S.P.

• Center for Neuropsychiatry, Taichung, Taiwan

autor

Lan Y.C.

• Department of Health Risk Management Taichung, Taiwan

autor

Lai C.H.

• Department of Microbiology, School of Medicine Taichung, Taiwan

autor

Lin C.W.

• Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan

autor

Tsai C.H.

• Graduate Institute of Chinese Medical Science, College of Chinese Medicine, Taichung, Taiwan

autor

Tsai F.J.

• Genetic Center, Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan
• Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan

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