Alterations in the hypoxic ventilatory response with advancing age in awake rats

• Autorzy: Pokorski M. , Antosiewicz J.
• Języki publikacji: EN

Abstrakty

EN

This study seeks to determine the influence of aging on hypoxic ventilatory responsiveness. We addressed the issue by comparing the hypoxic ventilatory responses in three age-groups of conscious rats: 3, 12, and 24 months old animals. Ventilation was recorded in a whole body rodent plethysmograph. Minute ventilation (E), respiratory rate, and tidal volume were considered for analysis. The rats were subjected to two levels of acute hypoxia: 14 and 11% O2 in N2. Hypoxic exposures were separated by a 15 min recovery interval in air. The part of the study between the 12 and 24 months age interval was longitudinal in that the same animals were studied twice, whereas the youngest animals belonged to a separate breed. All data were normalized to body mass. All hypoxic responses were biphasic with the stimulatory peak at 0.5 min after onset of hypoxia. The results demonstrate that there were no appreciable differences in magnitude of the peak hypoxic E responses between 3 and 12 months old rats. The hypoxic E responses and also the hypoxic ventilatory gain were, however, enhanced in the senescent rats. In these rats, the increment in peak E from 14 to 11% hypoxia amounted to 364.1±95.8 ml.min-1.kg-1, which was more than double compared with 12 and 3 months old rats (P<0.02). We conclude that ventilatory responsiveness is not curtailed in senescent rats. The respiratory system is able to compensate for any age-related handicaps in the respiratory system to maintain a stimulatory response to ventilatory stress.

Słowa kluczowe

EN

aging; body mass; breathing frequency; hypoxia; hypoxic ventilatory gain; hypoxic ventilatory response; rat; respiratory system; ventilation; ventilatory stress; man

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 2
• Opis fizyczny: p.227-232,fig.,ref.

Twórcy

autor

Pokorski M.

• Polish Academy of Science, 5 Pawinskiego Street, 02-106 Warsaw, Poland

autor

Antosiewicz J.

Bibliografia

• Grassi V, Cossi S, Leonardi R, Tantucci C. The aging lung: functional aspects. Aging (Milano) 1998; 10: 176-177.
• Janssens JP, Pache JC, Nicod LP. Physiological changes of respiratory function associated with ageing. Eur Respir J 1999; 13: 197-205.
• Levitzky MG. Effects of aging on the respiratory system. Physiologist 1984; 27: 102-107.
• DeLorey DS, Babb TG. Progressive mechanical ventilatory constraints with aging. Am J Respir Crit Care Med 1999; 160: 169-177.
• Pokorski M, Walski M, Dymecka A, Marczak M. The aging carotid body. J Physiol Pharmacol 2004; 55(Suppl 3): 107-113.
• Dymecka A, Walski M, Pokorski M. Ultrastructural degradation of the carotid body in the aged rat: is there a role for atherosclerosis in the main carotid arteries? J Physiol Pharmacol 2006; 57(Suppl 4): 85-90.
• Di Giulio C, Di Muzio M, Sabatino G, et al. Effect of chronic hyperoxia on young and old rat carotid body ultrastructure. Exp Gerontol 1998; 33: 319-329.
• Kronenberg RS, Drage CW. Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 1973; 52: 1812-1819.
• Peterson DD, Pack AI, Silage DA, Fishman AP. Effects of aging on ventilatory and occlusion pressure responses to hypoxia and hypercapnia. Am Rev Respir Dis 1981; 124: 387-391.
• Kawakami Y, Yoshikawa T, Shida A, Asanuma Y. Relationship between hypoxic and hypercapnic ventilatory responses in man. Jpn J Physiol 1981; 31: 357-368.
• Pokorski M, Marczak M. Ventilatory response to hypoxia in elderly women. Ann Human Biol 2003: 30: 53-64.
• Chapman KR, Cherniack NS. Aging effects on the interaction of hypercapnia and hypoxia as ventilatory stimuli. J Gerontol 1987; 42: 202-209.
• Serebrovskaya T, Karaban I, Mankovskaya I, Bernardi L, Passino C, Appenzeller O. Hypoxic ventilatory responses and gas exchange in patients with Parkinson’s disease. Respiration 1998; 65: 28-33.
• Schlenker EH, Goldman M. Ventilatory responses of aged male and female rats to hypercapnia and to hypoxia. Gerontology 1985; 31: 301-308.
• Fukuda Y. Changes in ventilatory response to hypoxia in the rat during growth and aging. Pflugers Arch 1992; 421: 200-203.
• Di Giulio C, Verratti V, Artese L, Petruccelli G, Walski M, Pokorski M. Aging and expression of heme oxygenase-1 and endothelin-1 in the rat carotid body after chronic hypoxia. J Physiol Pharmacol 2009; 60(Suppl 5): 41-44.
• Sokolowska B, Rekawek A, Jozwik A. Respiratory responses to acute intermittent hypoxia and hypercapnia in awake rats. J Physiol Pharmacol 2008; 59(Suppl 6): 659-667.
• Wysocka E, Cofta S, Cymerys M, Gozdzik J, Torlinski L, Batura-Gabryel H. The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients. J Physiol Pharmacol 2008; 59(Suppl 6): 761-769.
• Schlenker EH, Goldmann M. A developmental evaluation of ventilation in aspartic-acid obese rats. Fed Proc 1984; 43: 433.
• Ide T, Sakurai Y, Aono M, Nishino T. Contribution of peripheral chemoreception to the depression of the hypoxic ventilatory response during halothane anesthesia in cats. Anesthesiology 1999; 90: 1084-1091.
• Wenninger JM, Olson EB Jr, Cotter CJ, Thomas CF, Behan M. Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats. J Appl Physiol 2009; 106: 1522-1528.
• Budzinska K, Glowicki K, Karczewski WA, Kulesza J, Ryba M. The respiratory response to magnetic stimulation of the cortex in the unanaesthetized baboon. Acta Neurobiol Exp 1991; 51: 125-128.
• Aminnoff MJ, Sears TA. Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones. J Physiol 1971; 215: 557-575.
• Lipski J, Bektas A, Porter R. Short latency inputs to phrenic motoneurons from the sensorimotor cortex in the cat. Exp Brain Res 1986; 61: 280-290.
• Gandevia SC, Rothwell JC. Activation of the human diaphragm from the motor cortex. J Physiol 1987; 384: 109-118.
• Pokorski M, Trojecka A, Marczak M, Wierzbicka A, Jernajczyk W. Cortical activity during hypoxic hyperventilation. J Physiol Pharmacol 2003; 54(Suppl 1): 29-34.
• Marek W, Muckenhoff K, Prabhakar NR. Significance of pulmonary vagal afferents for respiratory muscle activity in the cat. J Physiol Pharmacol 2008; 59(Suppl 6): 407-420.
• Izumizaki M, Pokorski M, Homma I. Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse. J Appl Physiol 2004; 97: 1401-1407.
• Bouverot P, Candas V, Libert JP. Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits. Respir Physiol 1973; 17: 209-219.
• Martin-Body RL, Robson GJ, Sinclair JD. Respiratory effects of sectioning the carotid sinus glossopharyngeal and abdominal vagal nerves in the awake rat. J Physiol 1985; 361: 35-45.
• Olson EB Jr, Vidruk EH, Dempsey JA. Carotid body excision significantly changes ventilatory control in awake rats. J Appl Physiol 1988; 64: 666-671.
• Cragg PA, Schwenke DO. Role of carotid bodies in the guinea-pig. Adv Exp Med Biol 1996; 410: 377-381.
• Shock NW. Physiological aspects of aging in man. Ann Rev Physiol 1961; 23: 97-122.