Effect of MK-801 and acute prenatal hypoxia on optical density of mi-opioid receptors in developing rat brain
Hypoxia induces an elevation of excitotoxic amino acid concentrations and may influence hypoxic-in- duced basal ganglia injury. During pregnancy, hypoxia as the destructive factor of CNS alters concentration and mental retardation during childhood. The NMDA antagonist, MK-801, is known to block the effect of amino acids and protect the developing brain against hypoxic insults. To test the hypothesis that MK-801 change prenatal hypoxia affects on the optical density of the μ-opioid receptor system in the developing brain, we quantified optical density of the μ-opioid receptors in several areas of newborn rat brain. In the analysed cerebral structures of rats' brains short-lasting hypoxia leads to the decrease in optical density of n-opioid receptors. MK-801 lessens optical density of μ-opioid receptors in CPu, NA and LMPoA structures.