Effect of MK-801 and acute prenatal hypoxia on optical density of mi-opioid receptors in developing rat brain

• Autorzy: Kraczkowski J. , Smolen A. , Billewicz-Kraczkowska A. , Semczuk M.
• Języki publikacji: EN

Abstrakty

EN

Hypoxia induces an elevation of excitotoxic amino acid concentrations and may influence hypoxic-in- duced basal ganglia injury. During pregnancy, hypoxia as the destructive factor of CNS alters concentration and mental retardation during childhood. The NMDA antagonist, MK-801, is known to block the effect of amino acids and protect the developing brain against hypoxic insults. To test the hypothesis that MK-801 change prenatal hypoxia affects on the optical density of the μ-opioid receptor system in the developing brain, we quantified optical density of the μ-opioid receptors in several areas of newborn rat brain. In the analysed cerebral structures of rats' brains short-lasting hypoxia leads to the decrease in optical density of n-opioid receptors. MK-801 lessens optical density of μ-opioid receptors in CPu, NA and LMPoA structures.

Słowa kluczowe

EN

rat; brain; acute hypoxia; mi-opioid receptor; optical density; prenatal hypoxia; hypoxia; pregnancy

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2004
• Tom: 13
• Numer: Suppl.2, Part 1
• Opis fizyczny: p.245-248,ref.

Twórcy

autor

Kraczkowski J.

• Department of Obstetrics and Pathology of Pregnancy, Medical University in Lublin, Lublin, Poland

autor

Smolen A.

autor

Billewicz-Kraczkowska A.

autor

Semczuk M.