Changes of internal temperature and locomotor activity under the conditions of endotoxin fever, pyrogenic tolerance and its suppression in pigeons

• Autorzy: Dudek K. , Bednarek D. , Soszynski D. , Kozlowska M.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to investigate changes of internal temperature and locomotor activity of birds in conditions of endotoxin fever, pyrogenic tolerance and its suppression. The experiment was performed in pigeons (n = 12). On the first day of the experiment a state of endotoxin fever was evoked. The pigeons were categorized into two groups: experimental and control. The first group of the animals (n = 8) received Escherichia coli LPS intravenously once at the dose of 10 µg/kg b.w. whereas the control pigeons (n = 4) were administered in the apyrogenic saline intravenously once at the dose of 1 ml/kg b.w. On the second and third day of the experiment the state of pyrogenic tolerance was induced in the pigeons and their internal temperature and locomotor activity were investigated. To this end the experimental group of birds received E. coli LPS intravenously twice at 24 h intervals at a dose of 10 µg/kg b.w. Conversely, the control pigeons were twice treated with saline (1 ml/kg b.w.). On the fourth day of the study an attempt of pyrogenic tolerance suppression in the pigeons was carried out. The experimental birds with the stable state of pyrogenic tolerance were then categorized into two subgroups. The first subgroup (n = 4) received Salmonella Abortusequi LPS intravenously at the dose of 10 µg/kg b.w., whereas the second one (n = 4) - E. coli LPS at a double amount of the pyrogen (20 µg/kg b.w.). The control pigeons were administered S. Abortusequi LPS in an analogical dose as the first experimental subgroup. Results of the study indicated the occurrence of endotoxin fever and depression of locomotor activity of the pigeons in response to the first injection of E. coli LPS. The third administration of the pyrogen stabilized the state of pyrogenic tolerance, manifested by the reduction of the increased internal temperature and the stimulation of pigeon locomotor activity. Whereas in the state of stable pyrogenic tolerance in pigeons the intravenous injection of the other exogenous pyrogen, i.e. S. Abortusequi LPS, and also the double dose of E. coli pyrogen caused the suppression of the tolerance and the restoration of endotoxin fever in the birds.

Słowa kluczowe

EN

behavioural change; Escherichia coli; animal behaviour; bird; endotoxin; fever; internal temperature; lipopolysaccharide; locomotor activity; pigeon; pyrogenic tolerance; suppression; temperature change

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2011
• Tom: 67
• Numer: 01
• Opis fizyczny: p.38-47,fig.,ref.

Twórcy

autor

Dudek K.

• Department of Cattle and Sheep Diseases, National Veterinary Research Institute, 57 Partyzantow Avenue, 24-100 Pulawy, Poland

autor

Bednarek D.

autor

Soszynski D.

autor

Kozlowska M.

Bibliografia

• 1. Atkins E., Bodel P., Francis L.: Release of an endogenous pyrogen in vitro from rabbit mononuclear cells. J. Exp. Med. 1967, 126, 357-384.
• 2. Baert K., De Boever S., Duchateau L., De Backer P.: Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens. Br. Poult. Sci. 2005, 46, 144-148.
• 3. Berlin R. D., Wood W. B. Jr.: Studies on the pathogenesis of fever XIII. The effect of phagocytosis on the release of endogenous pyrogen by polymorphonuclear leukocytes. J. Exp. Med. 1964, 119, 715-726.
• 4. Blatteis C. M., Sehic E.: Fever: How may circulating pyrogens signal the brain? News Physiol. Sci. 1997, 12, 1-9.
• 5. Bodel P.: Studies on the mechanism of endogenous pyrogen production III. Human blood monocytes. J. Exp. Med. 1974, 140, 954-965.
• 6. Derijk R. H., Berkenbosch F.: Hypothermia to endotoxin involves the cytokine tumor necrosis factor and the neuropeptide vasopressin in rats. Am. J. Physiol. 1994, 266, R9-R14.
• 7. Dudek K.: Wpływ lipopolisacharydu na wystąpienie i przebieg gorączki, kształtowanie się tolerancji pirogenowej oraz wskaźniki immunologiczne i zapalne u gołębi. Praca dokt., Wydział Medycyny Weterynaryjnej AR, Lublin 2007.
• 8. Gourine A. V., Leon L. R., Rudolph K., Tesfaigzi J., Kluger M. J.: Cytokine cascade induced by endotoxin in TNF double receptor knockout mice: evidence supporting a role for IL-10 in mediating antipyretic action of TNF. J. Therm. Biol. 2000, 25, 21-27.
• 9. Gregorut F. P., Baptista L. C., Paulim A. S., Guerreiro J. R., Secato E. R., Macari M.: Influence of age on the febrile response to E. coli and S. typhimurium endotoxins in growing pullets. Br .Poult. Sci. 1992, 33, 769-774.
• 10. Hahn H. H., Char D. C., Postel W. B., Wood W. B. Jr.: Studies on the pathogenesis of fever XV. The production of endogenous pyrogen by peritoneal macrophages. J. Exp. Med. 1967, 126, 385-394.
• 11. Henderson B., Wilson M.: Cytokines induction by bacteria: beyond lipopolysaccharide. Cytokine 1996, 8, 269-282.
• 12. Jenkin C. R., Rowley D.: The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J. Exp. Med. 1961, 114, 1223-1236.
• 13. Johnson R. W., Curtis S. E., Dantzer R., Bahr J. M., Kelley K. W.: Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol. Behav. 1993, 53, 343-348.
• 14. Johnson R. W., Curtis S. E., Dantzer R., Kelley K. W.: Central and peripheral prostaglandins are involved in sickness behavior in birds. Physiol. Behav. 1993, 53, 127-131.
• 15. Jones C. A., Edens F. W., Denbow D. M.: Influence of age on the temperature response of chickens to Escherichia coli and Salmonella typhimurium endotoxins. Poult. Sci. 1983, 62, 1553-1558.
• 16. Kaszowska M.: Chemical stucture and biosynthesis of lipopolysaccharide - important component of the cell envelope of Gram-negative bacteria. Post. Hig. Med. Dosw. 2004, 58, 333-342.
• 17. Kawasaki H., Moriyama M., Ohtani Y., Naitoh M., Tanaka A., Nariuchi H.: Analysis of endotoxin fever in rabbits by using a monoclonal antibody to tumor necrosis factor (cachectin). Infect. Immun. 1989, 57, 3131-3135.
• 18. Kluger M. J.: Fever: role of pyrogens and cryogens. Physiol. Rev. 1991, 71, 93-127.
• 19. Kluger M. J., Kozak W., Leon L. R., Soszynski D., Conn C. A.: Cytokines and fever. Neuroimmunomodulation 1995, 2, 216-223.
• 20. Koutsos E. A., Klasing K. C.: The acute phase response in Japanese quail (Coturnix coturnix japonica). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2001, 128, 255-263.
• 21. Kozak W.: Fever as a homeostatic process accompanying infection. Post. Hig. Med. Dosw. 1992, 46, 67-91.
• 22. Kozak W., Soszynski D., Szewczenko M., Bodurka M.: Lack of pyrogenic tolerance transmission between brain and periphery in the rabbit. Experientia 1990, 46, 1010-1011.
• 23. Leshchinsky T. V., Klasing K. C.: Divergence of the inflammatory response in two types of chickens. Dev. Comp. Immunol. 2001, 25, 629-638.
• 24. Long N. C., Otterness I., Kunkel S. L., Vander A. J., Kluger M. J.: Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats. Am. J. Physiol. 1990, 259, R724-R728.
• 25. Macari M., Furlan R. L., Gregorut F. P., Secato E. R., Guerreiro J. R.: Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers. Br. Poult. Sci. 1993, 34, 1035-1042.
• 26. Mackowiak P. A., Bartlett J. G., Borden E. C., Goldblum S. E., Hasday J. D., Munford R. S., Nasraway S. A., Stolley P. D., Woodward T. E.: Concepts of fever: recent advances and lingering dogma. Clin. Infect. Dis. 1997, 25, 119-138.
• 27. Maloney S. K., Gray D. A.: Characteristics of the febrile response in Pekin ducks. J. Comp. Physiol. B 1998, 168, 177-182.
• 28. Nomoto S.: Diurnal variations in fever induced by intravenous LPS injection in pigeons. Pflügers Arch. – Eur. J. Physiol. 1996, 431, 987-989.
• 29. Nomoto S.: LPS fever in pigeons. Ann. N. Y. Acad. Sci. 1997, 813, 508-511.
• 30. Nomoto S.: Role of prostaglandin E2 and indomethacin in the febrile response of pigeons. Jpn. J. Physiol. 2003, 53, 253-258.
• 31. Nordlund J. J., Root R. K., Wolff S. M.: Studies on the origin of human leukocytic pyrogen. J. Exp. Med. 1970, 131, 727-743.
• 32. Roberts N. J. Jr.: Fever: Basic Mechanisms and Management. Raven Press. Ltd., New York 1991, pp. 125-142.
• 33. Roth J., deSouza G. E. P.: Fever induction pathways: evidence from responses to systemic or local cytokine formation. Braz. J. Med. Biol. Res. 2001, 34, 301-314.
• 34. Soszyński D.: Mechanisms for development of tolerance to repeated injections of exogenous pyrogens. Post. Hig. Med. Dośw. 2000, 54, 537-551.
• 35. Soszyński D.: Mechanizmy indukowania gorączki w stanach pobudzenia emocjonalnego. Praca hab., Wydział Lekarski AM, Bydgoszcz 2002.
• 36. Soszyński D., Kozak W., Szewczenko M.: Course of fever response to repeated administration of sublethal doses of lipopolysaccharides, polyinosinic:polycytidylic acid and muramyl dipeptide to rabbits. Experientia 1991, 47, 43-47.
• 37. Soszyński D., Krajewska M.: Lack of cross tolerance between pyrogenic effects of LPS and turpentine in rats. J. Therm. Biol. 2002, 27, 229-237.
• 38. Wilkinson M. F., Kasting N. W.: Centrally acting vasopressin contributes to endotoxin tolerance. Am. J. Physiol. 1990, 258, R443-R449.