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2011 | 67 | 02 |

Tytuł artykułu

Ocena aktywności wybranych enzymów antyoksydacyjnych we krwi koni z nawracającą chorobą obturacyjną dróg oddechowych

Warianty tytułu

EN
Evaluation of selected antioxidant enzymes in the blood of horses with recurrent airways obstruction

Języki publikacji

PL

Abstrakty

EN
The aim of this study was to evaluate the activity of antioxidant enzymes in horses diagnosed with recurrent airway obstruction (RAO). The study was conducted on a group of 40 horses, various breeds, divided into two groups, aged 8-15 years, including 15 males and 25 mares. Blood was collected for antioxidant analyses from 20 recurrent airway obstruction (RAO)-affected horses and 20 healthy control horses. The authors determined the activity of glutathione reductase, glutathione peroxidase and glutathione S-transferase in the blood. Average reductase activity in a group of healthy horses was 79.7 U/g, while in the group of RAO-affected horses it was 39.7 U/g. The average activity of glutathione peroxidase in the group of healthy horses was 47.8 U/g, while in the group of RAO-affected horses it was 37.8 U/g. The average activity of glutathione S-transferase in the group of healthy horses was 39.8 U/g, while in the group of RAO-affected horses it was 21.8 U/g. The resulting research indicates that oxidative stress is a consequence of chronic airway inflammation in the course of RAO in horses.

Wydawca

-

Rocznik

Tom

67

Numer

02

Opis fizyczny

s.129-132,rys.,bibliogr.

Twórcy

  • Katedra Chorób Wewnętrznych, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, pl.Grunwaldzki 47, 50-366 Wrocław
autor
autor
autor
autor

Bibliografia

  • 1.Art T., Kirschvink N., Smith N., Lekeux P.: Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Vet. J. 1999, 31, 397-401.
  • 2.Bannister W. H.: From haemocuprein to copper-zinc superoxide dismutase: a history on the fiftieth anniversary of the discovery of haemocuprein and the twentieth anniversary of the discovery of superoxide dismutase. Free Radic. Res. Commun. 1988, 5, 35-42.
  • 3.Byung P. Y.: Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 1994, 74, 139-162.
  • 4.Cannio R., Fiorentino G., Morana A., Rossi M., Bartolucci S.: Oxygen: friend or foe? Archaeal superoxide dismutases in the protection of intra- and extracellular oxidative stress. Front Biosci. 2000, 5, 768-779.
  • 5.Commoner B., Townsend J., Pake G. E.: Free radicals in biological materials. Nature 1954, 174, 689-691.
  • 6.Cuzzocrea S., Riley D. P., Caputi A. P., Salvemini D.: Antioxidant therapy: a new pharmacological approachin shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 2001, 53, 135-159.
  • 7.Deaton C. M., Marlin D. J., Smith N. C., Roberts C. A., Harris P. A., Schroter R. C., Kelley F. J.: Antioxidant and inflammatory responses of healthy horses and horses affected by recurrent airway obstruction to inhaled ozone. Equine Vet. J. 2005, 37, 243-249.
  • 8.Górecka R., Sitarska E., Kluciński W.: Antioxidant parameters of horses according to age, sex, breed and environment. Pol. J. Vet. Sci. 2002, 5, 209-216.
  • 9.Halliwell B.: How to characterize a biological antioxidant. Free Radic. Res. Commun. 1990, 9, 1-32.
  • 10.Halliwell B., Gutteridge J. M. C.: Role of free radicals and catalytic metal ions human disease: an overview. Methods Enzymol. 1990, 186, 1-85.
  • 11.Harman D.: Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11, 298-300.
  • 12.Harman D.: The aging process. Proc. Natl. Acad. Sci. USA 1981, 78, 7124-7128.
  • 13.Harvey J. W.: Pathogenesis, laboratory diagnosis, and clinical implications of erythrocyte enzyme deficiencies in dogs, cats, and horses. Vet. Clin. Pathol. 2006, 35, 144-156.
  • 14.Heaton M. B., Paiva M., Mayer J., Miller R.: Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum. Neurosci. Lett. 2002, 334, 83-86.
  • 15.Jacob R. A., Sotoudeh G.: Vitamin C function and status in chronic disease. Nutr. Clin. Care. 2002, 5, 66-74.
  • 16.Ji L. L., Dillon D. A., Bump K. D.: Antioxidant enzyme response to exercise in equine erythrocytes. Equine Vet. Sci. 1990, 10, 380-388.
  • 17.Kirschvink N., Art T., de Moffarts B., Smith N., Marlin D., Roberts C., Lekeux P.: Relationship between markers of blood oxidant status and physiologic variables in healthy and heaves-affected horses after exercise. Equine Vet. J. Suppl. 2002, 34, 159-164.
  • 18.Kirschvink N., Art T., Smith N., Lekeux P.: Effect of exercise and COPD crisis on isoprostane concentrationin plasma and bronchoalveolar lavage fluid in horses. Equine Vet. J. Suppl. 1999, 30, 88-91.
  • 19.Kirschvink N., Lekeux P.: Pferdeheilkunde. Oxidative stress in equine medicine - current knowledge. 2002, 18, 569-573.
  • 20.Matskevich G. N., Korotkina R. N., Devlikanova A. Sh., Vishnevskii A. A., Karelin A. A.: The study of the antioxidant enzymes in erythrocytes in lung diseases. Patol. Fizjol. Eksp. Ter. 2003, 2, 23-25.
  • 21.Mills P. C., Roberts C. A., Smith N. C.: Effects of ozone and airway inflammation on glutathionestatus and iron homeostasis in the lungs of horses. Am. J. Vet. Res. 1996, 57, 1359-1363.
  • 22.Mittal C. K., Murad F.: Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation. Proc. Natl. Acad. Sci. USA 1977, 74, 4360-4364.
  • 23.Moore R. M., Muir W. W., Granger D. N.: Mechanisms of gastrointestinal ischemia-reperfusion injury and potential therapeutic interventions: a review and its implications in the horse. J. Vet. Intern. Med. 1995, 9, 115-132.
  • 24.Nozik-Grayck E., Suliman H. B., Piantadosi C. A.: Extracellular superoxide dismutase. Int J. Biochem. Cell Biol. 2005, 37, 2466-2471.
  • 25.Williams C. A., Kronfeld D. S., Hess T. M., Saker T. E.: Antioxidant supplementation and subsequent oxidative stress of horses during an 80-km endurance race. J. Anim. Sci. 2004, 82, 588-594.
  • 26.Young I., Woodside J.: Antioxidants in health and Diseases. J. Clin. Pathol. 2001, 54, 176-186.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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