Magnesium in pathophysiology and therapy of affective disorders

• Autorzy: Poleszak E. , Nowak G.

Warianty tytułu

PL

Magnez w patofizjologii i terapii zaburzeń afektywnych

• Języki publikacji: EN

Abstrakty

EN

Magnesium possesses activity in a broad range of biochemical processes in living organisms. This review focus on the role of magnesium in pathophysiological and therapeutical mechanisms of affective disorders. Magnesium as an antagonist of the N-methyl-D- -aspartate (NMDA)/glutamate receptor complex, is active in the antidepressant screen test, forced swim test in rodents. Clinical studies, although providing very limited amount of data, suggest possible efficacy of magnesium in mania (bipolar affective disorders). Magnesium deficiency induced depression-like behavior in animals, and such an effect in humans is also suggested. All the available data indicate the importance of magnesium homeostasis in pathophysiology and therapy of affective disorders.

PL

Magnez odgrywa znaczącą rolę w funkcjonowaniu wielu procesów biochemicznych w żywym organizmie. W pracy dokonano oceny roli magnezu w patofizjologii i terapii zaburzeń afektywnych. Magnez jako antagonista receptora NMDA wykazuje aktywność w teście wymuszonego pływania u zwierząt. Badania kliniczne, chociaż dostarczają bardzo ograniczonej liczby danych, sugerują prawdopodobną skuteczność magnezu w terapii manii (zaburzenia afektywnego dwubiegunowego). Niedobór magnezu prowadzi do pojawienia się zaburzeń depresyjnych zarówno u zwierząt, jak i ludzi. Dostępne dane wskazują na ważną rolę homeostazy magnezowej w patofizjologii i terapii zaburzeń afektywnych.

Słowa kluczowe

EN

affective disorder; animal; biochemical process; depression-like behaviour; living organism; magnesium; magnesium deficiency; man; pathophysiology; therapy

• Wydawca: -
• Czasopismo: Journal of Elementology
• Rocznik: 2006
• Tom: 11
• Numer: 3

Twórcy

autor

Poleszak E.

• Department of Pharmacology and Pharmacodynamics, Skubiszewski Medical University of Lublin, Lublin, Poland

autor

Nowak G.

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