Apoptosis monitoring in human acute leukaemia cells stimulated by Bcl-2 antisense oligonucleotide and BAY K 8644

• Autorzy: Kocki J. , Kocki T. , Lancut M. , Bogucka-Kocka A. , Cioch M. , Dmoszynska A. , Wojcierowski J.
• Języki publikacji: EN

Abstrakty

EN

In this study we investigated effects of bcl-2 antisense oligonucleotides (AS) and BAY K 8644 (B), calcium channel agonist, on human leukaemic cells from non-treatment patients with acute myeloblastic leukaemias. Apoptotic cells were observed in electron and fluorescent microscopes. When we examined the effects of AS + B on cells, level of bcl-2 mRNA decreased more as in cells stimulated by AS only. These observations indicate that AS with B in human leukaemic cells disturb cell viability by inducing apoptosis.

Słowa kluczowe

EN

acute leukemia; acute leukemia cell; apoptosis; Bcl-2 gene; human disease; monitoring; oligonucleotide; antisense oligonucleotide; drug resistance

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2004
• Tom: 13
• Numer: Suppl.2, Part 1
• Opis fizyczny: p.225-227,fig.,ref.

Twórcy

autor

Kocki J.

• Department of Medical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-950 Lublin, Poland

autor

Kocki T.

autor

Lancut M.

autor

Bogucka-Kocka A.

autor

Cioch M.

autor

Dmoszynska A.

autor

Wojcierowski J.