Magnesium and calcium concentrations in tissues of mice receiving manganese in food
Manganese is very important trace element whose mechanism of actions involves activity regulation of enzymes taking part in key metabolic processes in organisms. It is a structural element of skin and bones, it also prevents osteoporosis. Its very important role in reproduction processes and in central nervous system has been already stated. The magnesium ion is of great importance in physiology by its intervention in 300 enzymatic systems, its membrane role and its function in neuromuscular excitability. The first pool of magnesium in organism is skeleton. The principal site of magnesium excretion are kidneys, which show important magnesium regulation mechanisms. For intestinal absorption, renal metabolism, bone accretion and resorption, magnesium shows analogies with calcium. Calcium is important macroelement in enzyme activation and inhibition, muscle and nerve function, and intracellular metabolism of all organisms. It is the main component of bones, where it is stored in organism. The aim of our work was to estimate influence of manganese chloride administration on concentrations of magnesium and calcium in mice tissues. Significant changes in magnesium and calcium content in dependence on the doses of administered manganese as well as the duration of the exposure have been stated in our experiment.