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2011 | 55 | 3 |
Tytuł artykułu

Porcine acute phase protein response to experimental infection with Bordetella bronchiseptica

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The response of five positive acute phase proteins (APP) was evaluated in pigs after infection with Bordetella bronchiseptica (Bbr). Twelve piglets from a herd with high health status were used. Six of them were infected intranasally with Bbr (3.4 x 10⁸ cfu). The standard bacteriological methods and PCR were used for detection of Bbr in nasal swabs, lungs, and bronchoalveolar fluids. Serum APP concentrations were measured using commercial tests. Various kinetics of response was identified within the APP tested. C-reactive protein and serum amyloid A was characterised as a ven fast, transient responder, while haptoglobin as a fast and very prolonged responder. Pig major acute phase protein was characterised as a fast, protracted responder. Alfa-l-acid-glycoprotein did not respond significantly after inoculation. No correlations were found between levels of APP in serum and changes in the turbinates. On the basis of the investigation we cannot state that evaluation of APP concentrations in serum may provide useful information about severity of atrophic rhinitis. However, the concentration of most investigated APP increased after inoculation. Thus, APP measurement could be the primary screening test prior to specific disease diagnosis. "APP-high" animals may be chosen next for pathogen-specific diagnostics. Moreover, monitoring of serum APP concentrations may be useful for selecting clinically healthy pigs before integration into an uninfected herd.
Wydawca
-
Rocznik
Tom
55
Numer
3
Opis fizyczny
p.371-375,fig.,ref.
Twórcy
  • Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
Bibliografia
  • 1. Alava M.A., González-Ramón N., Heegaard P., Guzylack S., Toussaint M. J. M., Lipperheide C., Madec F., Gruys E., Eckersal P.D., Lampreave F., Pifieiro A.: Pig-MAP, Porcine acute phase proteins and standardization of assays in Europe. Comp Haematol Int 1997, 7, 208-213.
  • 2. Asai T., Mori M., Okada M., Uruno K., Yazawa S., Shibata I.: Elevated serum haptoglobin in pigs infected with porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol 1999, 70, 143-148.
  • 3. Carpintero R., Alonso C., Pineiro M., Iturralde M., Andres M., La Potier M. F., Madec F., Alava M.A., Piñeiro A., Lampreave F.: Pig major acute phase protein and apolipoprotein A-I responses correlate with clinical course of experimentally induced African swine fever and Aujeszky's disease. Vet Res 2007, 38, 741-753.
  • 4. Christensen G., Sorensen V., Mousing J.: Diseases of the respiratory system. In: Diseases of swine. Edited by B.E. Straw, S. D'Allaire, W.L. Mengeling, and D.J. Taylor, Ames, USA, 1999, pp. 925-929.
  • 5. Chai L.A., Netea M.G., Teerenstra S., Earnest A., Vonk A.G., Schlamm H.T., Herbrecht R., Troke P.F., Kullberg B.J.: Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive aspergillosis. J Infect Dis 2010, 202, 1454-1462.
  • 6. Eckersall P.D., Saini P.K., McComb C.: The acute-phase response of acid-soluble glycoprotein, α(1)-acid glycoprotein, ceruloplasmin, haptoglobin and C-reactive protein, in the pig. Vet Immunol Immunopathol 1996, 51, 377-385.
  • 7. Francisco C.J., Shryock T.R., Bane D.P., Unverzagt L.: Serum haptoglobin concentration in growing swine after intranasal challenge with Bordatella bronchiseptica and toxigenic Pasteurella multocida tvpe D. Can J Vet Res 1996, 60, 222-227.
  • 8. Gatlin C.L., Jordan W.H., Shryock T.R., Smith W.C.: The quantitation of turbinate atrophy in pigs to measure the severity of induced atrophic rhinitis. Can J Vet Res 1996, 60, 121-126.
  • 9. Grau-Roma L., Heegaard P.M.H., Hjulsager C.K., Sibila M., Kristensen C.S., Allepuz A., Piñeiro M., Larsen L.E., Segalés J., Fraile L.: Pig-major acute phase protein and haptoglobin serum concentrations correlate with PCV2 viremia and the clinical course of postweaning multisystemic wasting syndrome. Vet Microbiol 2009, 138, 53-61.
  • 10. Gruys E., Obwolo M.J., Toussaint M.J.M.: Diagnostic significance of the major acute phase proteins in veterinary clinical medicine: A review. Vet Bull 1994, 64, 1011-1018.
  • 11. Hall W.F., Eurell T.E., Hansen R.D., Herr L.G.: Serum haptoglobin concentration in swine naturally or experimentally infected with Actinobacillus pleuropneumoniae. J Am Vet Med Assoc 1992, 201, 1730-1733.
  • 12. Heegaard P.M.H., Klausen J., Nielsen J.P., Gonzalez- Ramon N., Pineiro M., Lampreave F., Alava M.A.: The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection. Comp Biochem Physiol 1998, 119B, 365-373.
  • 13. Jong de M. F.: Progressive and nonprogressive atrophic rhinitis. In: Diseases of swine. Edited by B.E. Straw, J.J Zimmerman, S. D'Allaire, and D.J. Taylor. Blackwell Publishing, Ames, USA, 2006, pp. 577-602.
  • 14. Lampreave F., González-Ramón N., Martinez-Ayensa S., Hernández M., Lorenzo H., García-Gil A., Piñeiro A.: Characterization of the acute phase serum protein response in pigs. Electrophoresis 1994, 15, 672-676.
  • 15. Markowska-Daniel I., Stępniewska K., Pejsak Z.: Detection of Pasteurella multocida and Bordetella bronchiseptica, etiological agents of atrophic rhinitis, by means of PCR tests. Medycyna Wet 2010, 66, 45-50.
  • 16. Murata H., Shimada N., Yoshioka M.: Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J 2004, 168, 28-40.
  • 17. Petersen H.H., Nielsen J.P., Heegard P.M.: Application of the acute phase measurement in veterinary clinical chemistry. Vet Res 2004, 35, 163-187.
  • 18. Sorensen N.S., Tegtmeier C., Andresen L.O., Piñeiro M., Toussaint M.J., Campbell F.M., Lampreave F., Heegaard P.M.: The porcine acute phase protein response to acute clinical and subclinical experimental infection with Streptococcus suis. Vet Immunol Immunopathol 2006, 113, 157-168.
  • 19. Stepniewska K., Markowska-Daniel I.: Evaluation of PCR test for detection of dermonecrotoxin of Bordetella bronchiseptica. Bull Vet Inst Pulawy 2010, 54, 495-499.
  • 20. Tsiakalos A., Karatzaferis A., Ziakas P., Hatzis G.: Acute-phase proteins as indicators of bacterial infection in patients with cirrhosis. Liver Int 2009, 29, 1538-1542.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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