Porcine acute phase protein response to experimental infection with Bordetella bronchiseptica

• Autorzy: Pomorska-Mol M. , Urbaniak K. , Markowska-Daniel I.
• Języki publikacji: EN

Abstrakty

EN

The response of five positive acute phase proteins (APP) was evaluated in pigs after infection with Bordetella bronchiseptica (Bbr). Twelve piglets from a herd with high health status were used. Six of them were infected intranasally with Bbr (3.4 x 10⁸ cfu). The standard bacteriological methods and PCR were used for detection of Bbr in nasal swabs, lungs, and bronchoalveolar fluids. Serum APP concentrations were measured using commercial tests. Various kinetics of response was identified within the APP tested. C-reactive protein and serum amyloid A was characterised as a ven fast, transient responder, while haptoglobin as a fast and very prolonged responder. Pig major acute phase protein was characterised as a fast, protracted responder. Alfa-l-acid-glycoprotein did not respond significantly after inoculation. No correlations were found between levels of APP in serum and changes in the turbinates. On the basis of the investigation we cannot state that evaluation of APP concentrations in serum may provide useful information about severity of atrophic rhinitis. However, the concentration of most investigated APP increased after inoculation. Thus, APP measurement could be the primary screening test prior to specific disease diagnosis. "APP-high" animals may be chosen next for pathogen-specific diagnostics. Moreover, monitoring of serum APP concentrations may be useful for selecting clinically healthy pigs before integration into an uninfected herd.

Słowa kluczowe

EN

acute phase; protein response; experimental infection; Bordetella bronchiseptica; pig; acute phase protein; early diagnosis; diagnosis; animal infection; piglet; herd

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2011
• Tom: 55
• Numer: 3
• Opis fizyczny: p.371-375,fig.,ref.

Twórcy

autor

Pomorska-Mol M.

• Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland

autor

Urbaniak K.

autor

Markowska-Daniel I.

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