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2008 | 64 | 06 |
Tytuł artykułu

Blood serum ascorbic acid evaluated in patients suffering from liver and pancreas diseases and in the liver, heart, kidneys and lungs of rats intoxicated with CCl4 and galactosamine

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was to evaluate blood serum ascorbic acid levels in patients with hepatic cirrhosis, acute and chronic pancreatitis and in the liver, heart, kidneys and lungs of rats intoxicated with CCl₄ and galactosamine. The results revealed statistically significant increases in the blood plasma ascorbic acid levels in patients with acute and chronic pancreatitis and hepatic cirrhosis. In the group of patients with chronic pancreatitis, however, the blood plasma ascorbic acid levels were not different from the controls. In the group of control rats the highest ascorbic acid levels were observed in the liver and the lowest in the heart. In the intoxicated rats with CCl₄ and galactosamine the kidneys’ ascorbic acid contents increased significantly after administration of both toxins in single doses but decreased after 3-days of administration of CCl₄. In the liver, decreased ascorbic acid contents were observed after single doses of CCl4 and galactosamine, but after the 3-day administration its contents were increased. The content of ascorbic acid in the lung increased after each of the toxins used. In the heart, ascorbic acid contents decreased considerably after single and three-day CCl₄ and galactosamine administration as well.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
64
Numer
06
Opis fizyczny
p.778-781,ref.
Twórcy
autor
  • Department of Gastroenterology with Endoscopic Units, Skubiszewski Medical University, Jaczewski Str. 8, 20-954 Lublin, Poland
autor
autor
Bibliografia
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  • 4.Cervinhova Z., Bgatova N. P., Shorina T. G., Holecek M.: Structural and functional changes after the administration of CCl4 in the liver of rats fed on diets with different protein contents. Physiol. Bohemoslov. 1987, 36, 349-359.
  • 5.Du W. D., Yuan Z. R., Sun J., Tang J. X., Cheng A. Q., Shen D. M., Huang Ch., Song X. H., Yu X. F., Zheng S. B.: Therapeutic efficacy o high-dose ascorbic acid on acute pancreatitis and its potential mechanism. World J. Gastroenetrol. 2003, 9, 2565-2569.
  • 6.Ferenčikowá R., Červinková Z., Drahota Z.: Hepatotoxic effect of d-galactosamine and protective role of lipid emulsion. Physiol. Res. 2003, 52, 73-78.
  • 7.George J.: Ascorbic acid concentrations in dimethylnitrosamine-induced fibrosis in rats. Clin. Chim. Acta. 2003, 335, 39-47.
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  • 10.Kirk G. R., White J. S., Mc Kie L., Stevenson M., Young I., Clements W. D., Rowlands B. J. L.: Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J. Gastrointet. Surg. 2006, 10, 499-503.
  • 11.Loo van der B., Bachschmid M., Spitzer V., Brey, Ulrich V., Luscher T. F.: Decreased plasma and tissue levels of ascorbic acid in a rat model of aging: implications of antioxidative defense. Biochem. Biophys. Res. Commun. 2003, 303, 483-487.
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  • 14.Patra R. C., Swarup D., Dwivedi S. K.: Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001, 162, 81-88.
  • 15.Sajewicz W., Milnerowicz S., Nabzdyk S.: Blood plasma antioxidant defense in patients with pancreatitis. Pancreas 2006, 32, 139-144.
  • 16.Schwedhelm E., Maas R., Troost R., Böger R. H.: Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress. Clin Pharmacokinet. 2003, 42, 437-459.
  • 17.Scott P., Bruce C., Schofield D., Shiel N., Braganza J. M., McCloy R. F.: Ascorbic acid status with patients with acute pancreatitis. Br. J. Surg. 1993, 80, 750-754.
  • 18.Smialowicz R. J., Simons J. E., Luebke R. W., Allis J. W.: Immunotoxicologic assessment of subacute exposure of rats to carbon tetrachloride with comparison to hepatotoxicity and nephrotoxicity. Fundam. Appl. Toxicol. 1991, 17, 186-196.
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Bibliografia
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