PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 66 | 12 |
Tytuł artykułu

Cytotoksyczność nanocząsteczek srebra

Autorzy
Warianty tytułu
EN
Cytotoxicity of silver nanoparticles
Języki publikacji
PL
Abstrakty
EN
Nanotechnology concerns the study, creation and manipulation of structures, devices, and systems at a nanoscale level. Such materials exhibit unique biological, physical and chemical properties compared to bulk materials, and are readily utilized in modern medicine and industry. Currently silver nanoparticles (SNP) are among the most commonly used nanomaterials due to their antimicrobial properties. Nanosilver can be found in medical devices, filters for water purification and in many consumer products as well. However, some recent studies indicate that nanosilver formulations may be cytotoxic to various types of both animal and human cells. Because their size is similar to cellular components they are able to bypass cell membranes, which results in cytotoxicity, although the exact mechanism of such an interaction is yet to be established. Several studies have reported the accumulation of SNP inside cells and their impact on cell morphology, while many of them claim that nanosilver induces cell necrosis or apoptosis due to decreasing function of mitochondria and catalyzes the production of reactive oxygen species, which leads to oxidative stress. Some reports indicate NPS can affect the physiology of immune competence and even of stem cells, which is of great importance for such crucial biological phenomena as the immunity and fertility of organisms. Taking into consideration all of the above and the fact of growing exposure of human bodies to increasing doses of nanoparticles, there is a real need for evaluating the potential risks of using nanosilver in our everyday lives.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
66
Numer
12
Opis fizyczny
s.833-838,bibliogr.
Twórcy
  • Katedra Mikrobiologii i Immunologii Klinicznej, Wydział Medycyny Weterynaryjnej, Uniwersytet Warmińsko-Mazurski w Olsztynie, ul.Oczapowskiego 13, 10-718 Olsztyn
Bibliografia
  • 1.Agarwal A., Weis T. L., Schurr M. J., Faith N. G., Czuprynski C. J., McAnulty J. F., Murphy C. J., Abbott N. L.: Surfaces modified with nanometr-thick silver-impregnated polymeric films that kill bacteria but support growth of mammalian cells. Biomaterials 2010, 31, 680-690.
  • 2.Arora S., Jain J., Rajwade J. M., Paknikar K. M.: Cellular responses induced by silver nanoparticles: In vitro studies. Toxicol. Lett. 2008, 179, 93-100.
  • 3.Arora S., Jain J., Rajwade J. M., Paknikar K. M.: Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicol. Appl. Pharmacol. 2009, 236, 310-318.
  • 4.Bogacka A., Kucharska E.: Wpływ hemodializy na produkcję wolnych rodników i nasilenie stresu oksydacyjnego. Immunologia kliniczna: wybrane aspekty. EDYCJA s.c., Olsztyn 2010, 193-202.
  • 5.Braydich-Stolle L., Hussain S., Schlager J. J., Hofmann M. C.: In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol. Sci. 2005, 2, 412-419.
  • 6.Farkas J., Christian P., Gallego Urea J. A., Roos N., Hassellöv M., Tollefsen K. E., Thomas K. V.: Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 2010, 96, 44-52.
  • 7.Foldbjerg R., Olsen P., Hougaard M., Dang D. A., Hoffmann H. J., Autrup H.: PVP-coated silver nanoparticles and silver ions induced reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol. Lett. 2009, 190, 156-162.
  • 8.Gopinath P., Gogoi S. K., Chattopadhyay A., Ghosh S. S.: Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy. Nanotechnology 2008, 19, 1-10.
  • 9.Hsin Y. H., Chen C. F., Huang S., Shih T. S., Lai P. S., Chueh P. J.: The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol. Lett. 2008, 179, 130-139.
  • 10.Hussain S. M., Hess K. L., Gearhart J. M., Geiss K. T., Schlager J. J.: In vitro toxicity of nanoparticles in BRL3A rat liver cells. Toxicol. in Vitro 2005, 19, 975-983.
  • 11.Kalishwaralal K., Banumathi E., Ram Kumar Pandian S., Deepak V., Muniyandi J., Eom S. H., Gurunathan S.: Silver nanoparticles inhibit VEGF induced cell proliferation and migration in bovine retinal endothelial cells. Colloids Surf. B 2009, 73, 51-57.
  • 12.Kumari M., Mukherjee A., Chandrasekaran N.: Genotoxicity of silver nanoparticles in Allium cepa. Sci. Total Environ. 2009, 407, 5243-5246.
  • 13.Lubick N.: Nanosilver toxicity: ions, nanoparticles - or both? Environ. Sci. Technol. 2008, 42, 8617.
  • 14.Luoma S. N.: Silver nanotechnologies and the environment: old problems or new challenges? PEN 15, september 2008 (report by Project on Emerging Nanotechnologies; http://www.nanotechproject.org/publications/).
  • 15.Miura N., Shinohara Y.: Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells. Biochem. Biophys. Res. Commun. 2009, 390, 733-737.
  • 16.Murawala P., Phadnis S. M., Bhonde R. R., Prasad B. L.: In situ synthesis of water dispersible bovine serum albumin capped gold and silver nanoparticles and their cytocompatibility studies. Colloids Surf. B 2009, 73, 224-228.
  • 17.Park E. J., Yi J., Kim Y., Choi K., Park K.: Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol. in Vitro 2010, 24, 872-878.
  • 18.Poon V. K., Burd A.: In vitro cytotoxicity of silver: implication for clinical wound care. Burns 2004, 30, 140-147.
  • 19.Rosas-Hernandez H., Jimenez-Badillo S., Martinez-Cuevas P. P., Gracia-Espino E., Terrones H., Terrones M., Hussain S. M., Ali S. F., Gonzalez C.: Effects of 45-nm silver nanoparticles on coronary endothelial cells and isolated rat aortic rings. Toxicol. Lett. 2009, 191, 305-313.
  • 20.Santoro C. M., Duchsherer N. L., Grainger D. W.: Minimal in vitro antimicrobial efficacy and ocular cell toxicity from silver nanoparticles. Nanobiotechnol. 2007, 3, 55-65.
  • 21.Shin S. H., Ye M. K., Kim H. S., Kang H. S.: The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells. Int. Immunopharmacol. 2007, 7, 1813-1818.
  • 22.Sir Wise J. P., Goodale B. C., Wise S. S., Craig G. A., Pongan A. F., Walter R. B., Thompson W. D., Ng A.-K., Aboueissa A. M., Mitani H., Spalding M. J., Mason M. D.: Silver nanospheres are cytotoxic and genotoxic to fish cells. Aquat. Toxicol. 2010, 97, 34-41.
  • 23.Wataha J. C., Lockwood P. E., Schedle A., Noda M.: Ag, Cu, Hg and Ni ions alter the metabolizm of human monocytes during extender low-dose exposures. J. Oral Rehabil. 2002, 29, 133-139.
  • 24.Yen H. J., Hsu S. H., Tsai C. L.: Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 2009, 5, 1553-1561.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.dl-catalog-34bd7984-e487-46b2-b467-9ec1d2e26e83
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.