Ratio of urinary alpha-amylase activity to creatinine concentration: a new diagnostic marker for pancreatitis in dogs?
The hypothesis that acute pancreatitis in dogs could be diagnosed based on the ratio of urinary α-amylase activity to creatinine concentration (U-A/C) was tested. The study was performed on 292 dogs. Based on clinical, laboratory , and imaging findings, the dogs were divided into the following groups: 34 healthy patients serving as the control, 48 sick dogs with U-A/C>2.9, and 210 sick dogs with U/A-C<2.9. The sick dogs were subsequently divided into subgroups according to their diseases. The results of blood and urine analyses of sick dogs were compared to those of healthy dogs. The subgroups of dogs with U-A/C>2.9 differed from the control group in the same way: their serum and urine α-amylase activity and total urinary protein levels were significantly higher (P>0.001 ), and their urine specific gravity and urinary creatinine concentration were significantly lower (P<0.001). Acute or chronic pancreatitis was confirmed in many of the sick dogs with U-A/C>2.9 that were tested by ultrasonography (48%, 10/21) and histopathology (100%, 7/7). The findings might suggest that U-A/C ratio higher than 2.9 could serve as a cut-off value for diagnosing pancreatitis in dogs (excluding advanced chronic pancreatitis), regardless of concurrent diseases.
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