Wpływ statusu zdrowotnego zwierząt laboratoryjnych: myszy i szczurów na wiarygodność wyników badań

• Autorzy: Peszynska-Sularz G. , Zylko A. , Muszynska-Furas B. , Paradziej-Lukowicz J.

Warianty tytułu

EN

Influence of the health status of laboratory animals: mice and rats on the credibility of research results

• Języki publikacji: PL

Abstrakty

EN

The study describes the influence of the health condition of laboratory animals used in experiments on the credibility and repeatability of research results obtained. It also presents a classification of animals into health categories depending on their microbiological purity: germ-free animals, specific pathogen-free animals and conventional animals. Detailed conditions which have to be fulfilled by animal quarters with a sanitary-hygienic barrier in order to keep specific pathogen-free animals (SPF) are also discussed. Moreover, the study describes general rules compliant with European standards for monitoring the health of laboratory animals, including a detailed register of detected pathogens specific for mice and rats. Numerous pathways of disease spread and their influence on the course of the experiment are pointed out. What is more, examples of the influence of contamination on animal biology and the results of experiments are presented. The table attached contains specific pathogens of mice and rats, which often significantly influence the course of experiments and should be regularly monitored. Pathogens which may cause zoonoses in people are also marked.

Słowa kluczowe

PL

doswiadczenia na zwierzetach; monitoring; myszy; stan zdrowotny; szczury; wiarygodnosc; wyniki badan; zwierzeta laboratoryjne; zwierzeta SPF

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 11
• Opis fizyczny: s.761-764,tab.,bibliogr.

Twórcy

autor

Peszynska-Sularz G.

• Trójmiejska Akademicka Zwierzętarnia Doświadczalna – Centrum Badawczo-Usługowe, Gdański Uniwersytet Medyczny, ul.Dębinki 1, 80-211 Gdańsk

autor

Zylko A.

autor

Muszynska-Furas B.

autor

Paradziej-Lukowicz J.

Bibliografia

• 1.Anusz Z.: Choroby odzwierzęce. Wyd. ART, Olsztyn 1991.
• 2.Baker G. D.: Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin. Microbiol. Rev. 1998, 233-235.
• 3.Blackmore D. K.: Accidental contamination of a specified-pathogen-free unit. Laboratory Animals 1972, 257-271.
• 4.Brylińska J., Kwiatkowska J.: Zwierzęta laboratoryjne, metody hodowli i doświadczeń. Universitas, Kraków 1996.
• 5.Hau J., van Hoosier G. L.: Handbook of Laboratory Animals Science. Essential Principles and Practices. CRC Press, New York, USA 2003, s. 313.
• 6.Kaliste E.: The welfare of Laboratory Animals. Infections in laboratory animals: importance and control. Kluwer Academic Publishers, Dordrecht, The Netherlands 2007, 23-35.
• 7.Katkiewicz M.: Zwierzęta laboratoryjne - choroby i użytkowanie. Wyd. SGGW-AR, Warszawa 1989, s. 5.
• 8.Krzanowska H., Preibisch J., Korda P.: Zwierzęta laboratoryjne - choroby i użytkowanie. PZWL, Warszawa 1974.
• 9.Russell W. M. S., Burch R. L.: The Principles of Humane Experimental Technique. Methuen, London 1959.

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