Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus

• Autorzy: Valdovska A. , Pilmane M.
• Języki publikacji: EN

Abstrakty

EN

Parvovirus of Aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. In mink farms of Latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. The goal of this study was to examine probability of liver damage and regeneration of mink infected with Aleutian disease virus. Liver injury was assessed histologically. The mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. In immunohistochemistry, during liver regeneration the matrix metalloproteinases MMP-9, vascular endothelial growth factor and β-defensin 2 expressions were lower, but MMP-2 and nerve growth factor receptor p75 expression was increased.

Słowa kluczowe

EN

Aleutian disease; Aleutian mink disease parvovirus; animal infection; beta-defensin-2; histopathology; immunohistochemistry; liver; liver parenchyma; mink; nerve growth factor receptor; metalloproteinase

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2011
• Tom: 14
• Numer: 1
• Opis fizyczny: p.69-76,fig.,ref.

Twórcy

autor

Valdovska A.

• Faculty of Veterinary Medicine, Latvian University of Agriculture, 8 K.Helmana street, Jelgava, LV – 3004, Latvia

autor

Pilmane M.

Bibliografia

• Arthur MJ (1997) Matrix degradation in liver: a role in injury and repair. Hepatology 26: 1069-1071.
• Arthur MJ (1998) Fibrosis and altered matrix degradation. Digestion 59: 376-380.
• Asai K, Tamakawa S, Yamamoto M, Yoshie M, Tokusashi Y, Yaginuma Y, Kasai S, Ogawa K (2006) Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation. Liver Int 26: 595-603.
• Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA (1993) Matrix metalloproteinase: a review. Crit Rev Oral Biol Med 4: 197-250.
• Blechacz B, Russell SJ (2004) Parvovirus vectors: use and optimisation in cancer gene therapy. Expert Rev Mol Med 6: 1-24.
• Brogden KA, Ackermann M, McCray PB Jr, Tack BF (2003) Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents 22: 465-478.
• Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF (2006) The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng 12: 519-526.
• Coenjaerts FE, van der Flier M, Mwinzi PN, Brouwer AE, Scharringa J, Chaka WS, Aarts M, Rajanuwong A, van de Vijver DA, Harrison TS, Hoepelman AI (2004) Intrathecal production and secretion of vascular endothelial growth factors during Cryptococcal Meningitis. J Infect Dis 190: 1310-1317.
• Ensoli B, Sgadari C, Barillari G, Monini P (2003) The fibroblast growth factors. In: Thomson AW, Lotze MT (eds) The Citokine Handbook. vol II, Academic Press, Boston, pp 747-771.
• Esser S, Wolburg K, Wolburg H, Breier G, Kurzchalia T, Risau W (1998) Vascular endothelial growth factor induces endothelial fenestrations in vitro. J Cell Biol 140: 947-959.
• Frappier BL (2006) Digestive System. In: Eurell JA, Frappier BL (eds) Dellmann’s Textbook of Veterinary Histology. 6th ed., Blackwell Publishing, Ames, pp 201-206.
• Friedman SL (1999) Cytokines and fibrogenesis. Semin Liver Dis 19: 129-140.
• Friedman SL (2003) Liver fibrosis – from bench to bedside. J Hepatol 1: S38-S53.
• Friedman SL (2005) Mac the knife? Macrophages – the double-edged sword of hepatic fibrosis. J Clin Invest 115: 29-32.
• Green DR (1998) Apoptotic pathways: the roads to ruin. Cell 94: 695-698.
• Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
• Hanumegowda UM, Copple BL, Shibuya M, Malle E, Ganey PE, Roth RA (2003) Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicol Sci 76: 237-246.
• Makino H, Shimizu H, Ito H, Kimura F, Ambiru S, Togawa A, Ohtsuka M, Yoshidome H, Kato A, Yoshitomi H, Sawada S, Miyazaki M (2006) Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy. World J Gastroenterol 12: 2053-2059.
• Hunter DB (1996) Aleutian disease. In: Hunter DB, Lemieux N (eds) Mink: Biology, health and disease. University of Guelph, Ontario, pp 21-27.
• Hsu SM, Raine L, Fanger H (1981) The use of antiavidin antibody and avidin-biotin – peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75: 816-821.
• Ishikawa KS, Masui T, Ishikawa K, Shiojiri N (2001) Immunolocalization of hepatocyte growth factor and its receptor (c-Met) during mouse liver development. Histochem Cell Biol 116: 453-462.
• Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP (2001) Apoptosis of hepatic stellate cells: involvement in resolution of billiary fibrosis and regulation by soluble growth factors. Gut 48: 548-557.
• Jepsen OR, Poulsen FS, Jorgensen G (1981) Collection of blood, sedation and anaesthesia in mink. Nord Vet Med 1: 1-99.
• Joplin R, Hishida T, Tsubouchi H, Daikuhara Y, Ayres R, Neuberger JM, Strain AJ (1992) Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor. J Clin Invest 90: 1284-1289.
• Kelly RW (1993) The liver and biliary system.In: Jubb KV, Kennedy PC, Palmer N (eds) Pathology of domestic animals. Academic Press, California, pp 319-362.
• Klatskin G, Conn HO (1993) Histopathology of the Liver, vol 1, Oxford University Press, New York.
• Laskin DL (1990) Nonparenchymal cells and hepatotoxicity. Semin Liver Dis 10: 293-304.
• Lehmann J, Retz M, Harder J, Krams M, Kellner U, Hartmann J, Hohgrawe K, Raffenberg U, Gerber M, Loch T, Weichert-Jacobsen K, Stockle M (2002) Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection. BMC Infect Dis 18: 2-20.
• Lehrer RI, Ganz T (2002) Defensins of vertebrate animals. Curr Opin Immunol 14: 96-102.
• Lindroos PM, Zarnegar R, Michalopoulos GK (1991) Hepatocyte growth factors (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 13: 743-750.
• Maher JJ (1993) Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest 91: 2244-2252.
• Murphy CJ, Foster BA, Mannis MJ, Selsted ME, Reid TW (1993) Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 155: 408-413.
• Negoescu A, Guillermet C, Lorimier P, Brambilla E, Labat-Moleur F (1998) Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomed Pharmacother 52: 252-258.
• Nolan A, Weiden MD, Thurston G, Gold JA (2004) Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis. Inflammation 28: 271 278.
• Oakley F, Trim N, Constandinou CM, Ye W, Gray AM, Frantz G, Hillan K, Kendall T, Benyon RC, Mann DA, Iredale JP (2003) Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis. Am J Pathol 163: 1849-1858.
• Passino MA, Adams RA, Sikorski SL, Akassoglou K (2007) Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75 NTR. Science 315: 1853-1856.
• Pilmane M, Luts A, Sundler F (1995) Changes in neuroendocrine elements in bronchial mucosa in chronic lung diseases in adults. Thorax 50: 551-554.
• Rajkumar T (2001) Growth factors and growth factor receptors in cancer. Curr Sci India 81: 535-541.
• Reif S, Somech R, Brazovski E, Reich R, Belson A, Konikoff FM, Kessler A (2005) Matrix metalloproteinases 2 and 9 are markers of inflammation but not of the degree of fibrosis in chronic hepatitis C. Digestion 71: 124-130.
• Schulte-Hermann R, Bursch W, Low-Baselli A, Wagner A, Grasl-Kraupp B (1997) Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol Toxicol 13: 339-348.
• De Smet K, Contreras R (2005) Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett 27: 1337-1347.
• Taniguchi E, Sakisaka S, Matsuo K, Tanikawa K, Sata M (2001) Expression and role of vascular endothelial growth factors in liver regeneration after partial hepatectomy in rats. J Histochem Cytochem 49: 121-130.
• Thannickal VJ, Fanburg BL (2000) Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279: L1005-L1028.
• Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J (2000) Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerwe growth factor stimulation. Am J Pathol 156: 1235-1243.
• Twining SS (1994) Regulation of proteolytic activity in tissues. Crit Rev Biochem Mol Biol 29: 315-383.
• Ueda T, Takeyama Y, Yasuda T, Matsumura N, Sawa H, Nakajima T, Kuroda Y (2006) Vascular endothelial growth factor increases in serum and protects against the organ injuries in severe acute pancreatitis. J Surg Res 134: 223-230.
• Visse R, Nagase H (2003) Matrix metalloproteinases and Tissue inhibitors of metalloproteinases: structure, function and biochemistry. Circ Res 92: 827-839.
• Watanabe H, Sumi S, Kitamura Y, Nio Y, Higami T (2003) Immunohistochemical analysis of vascular endothelial growth factor and hepatocyte growth factor, and their receptors, in transplanted islets in rats. Surg Today 33: 854-860.
• Wu J, Zern MA (2000) Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 35: 665-672.