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2012 | 59 | 4 |
Tytuł artykułu

Role of heat-shock proteins and cobalamine in maintaining methionine synthase activity

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
 Atheromatous plaque is one of the most common cardiovascular-related diseases. Reports show a connection between its development and the levels of homocysteine. In pathological states high levels of homocysteine in the organism can be caused by the malfunction of the methionine synthase pathway. Bacterial methionine synthase (MetH) is a homologue of the human methionine syntase (MS). In this study we aimed to investigate the functional relations between MetH and its cofactor - cobalamine - under stress conditions. We have demonstrated that heat shock proteins (Hsp 70/100 system or HtpG) can protect MetH activity under stress conditions. Moreover, in the presence of cobalamine they can restore the activity of partially denatured methionine synthase.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
59
Numer
4
Opis fizyczny
p.489-493,fig.,ref.
Twórcy
autor
  • Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland
autor
  • Department of Biotechnology, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland
autor
  • Department of Microbiology, University of Szczecin, Szczecin, Poland
  • Department of Molecular Biology University of Gdańsk, Poland
autor
  • Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland
  • Department of Neurology, Medical University of Gdańsk, Poland
autor
  • Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland
Bibliografia
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