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2013 | 73 | Suppl.1 |

Tytuł artykułu

Effects of neonatal maternal separation on LTP saturation and LTD saturation in lateral amygdala of the rat

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The maternal separation (MS) procedure represents a paradigm to study disturbances in brain function that might occur in response to stressful events during postnatal development. However, mechanisms by which early life stress affects synaptic plasticity in the amygdala are poorly understood. This study was aimed at finding the effects of repeated MS on saturation of LTP and LTD in the cortical (CoI) and the thalamic input (ThI) to the lateral amygdala (LA) of rats. Wistar dams with their offspring were housed under 12:12 L/D conditions with food and water available ad libitum. On each postnatal day (PND) 1–21 rats were subjected to MS (3 h/day). For ex vivo electrophysiological experiments rats between PND 35 and PND 55 were used. The animals were anesthetized and brain slices containing LA (450 µm) were cut. Field potentials (FPs) were evoked by the stimulation of CoI or ThI to LA. LTP was induced using theta-burst stimulation (TBS) and LTD was induced using low frequency stimulation (LFS). Both protocols were repeated every 45 minutes until maximum level of LTP or LTD was reached. In CoI we observed impairment of maximum LTP and enhancement of maximum LTD in slices prepared from MS subjected rats, however in ThI, both maximum LTP and maximum LTD was impaired when compared to control, animal facility reared (AFR) rats.

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-

Rocznik

Tom

73

Numer

Opis fizyczny

p.58-59

Twórcy

  • Institute of Zoology, Jagiellonian University, Krakow, Poland
  • Institute of Zoology, Jagiellonian University, Krakow, Poland
autor
  • Institute of Zoology, Jagiellonian University, Krakow, Poland
  • Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

Bibliografia

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Bibliografia

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