Electrical activity of limbic structures during classical fear conditioning after temporal blockade de basolateral complex of amygdale in rats

• Autorzy: Rejniak K. , Olszewski M. , Kasicki S.
• Języki publikacji: EN

Abstrakty

EN

BACKGROUND AND AIMS: The basolateral complex of amygdala (BLA) and nucleus accumbens (NAc) are involved in acquisition and extinction of the conditioned fear. The aim of our study was to verify if the electrical activity of these structures is correlated with the behavior of rats during fear conditioning after tetrodotoxin (TTX) blockade of BLA. The disturbances of cognitive function (learning) were estimated on the basis of the conditioned fear response. METHODS: Male Wistar rats were implanted with electrodes in right NAc and BLA, guides bilaterally in BLA and divided in 2 groups: A-TTX group (TTX infused before acquisition sessions), E-TTX group (TTX before the first 3 extinction sessions). As a CS we used a tone associated at the end with electric shock (acquisition) or a tone alone (extinction). During each session we recorded local field potentials (LFPs) in NAc and BLA. The number of boli and rat behavior (video) were also recorded. RESULTS: Infusion of TTX resulted in longest freezing duration both in A-TTX and E-TTX groups. In the A-TTX group the number of boli in acquisition sessions was smaller than in extinction sessions, while in the E-TTX group it was greater than in extinction sessions. The number of boli in all sessions was higher in the E-TTX group. Analysis of LFPs showed that in the A-TTX group there were practically no differences in frequency bands power between all sessions. The same analysis for the E-TTX group showed many differences between all sessions. CONCLUSIONS: Our results are in line with previous data that blockade of BLA during acquisition sessions prevents conditioning, and at LFP level the activity was not different between sessions. Results of the group E-TTX show that the activity in BLA and NAc is changing parallel to changes in behavior what may reflect neural processes involved in acquisition and extinction of conditioned response. Project funded by the National Center of Science DEC-2011/03/B/ NZ4/03768.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S84-S85

Twórcy

autor

Rejniak K.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Olszewski M.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

autor

Kasicki S.

• Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland