Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats

• Autorzy: Yildizhan E. , Ozesmer H. , Inan M.M. , Tatli F. , Rencber M. , Akbas A. , Kamar M. , Gunduz E. , Baksi N. , Ulger B.V. , Akkus M. , Kaydu A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study is to determine the protective efficacy of anise in cerebral ischemia and reperfusion injury in rats. In this study, 28 Wistar Albino rats, weighing 250-300 grams (g), were used. Four groups were formed with 7 rats in each group. Group 1 (n=7): Control group, Group 2 (n=7): Anise group, 5 mL/kg/day of anise aqueous extract prepared according to Gamberini’s protocol was given orally by gavage for 30 days. Group 3 (n=7): Cerebral ischemia reperfusion (CIR) group, at the beginning of the experiment, 30 minutes of cerebral ischemia and 1 hour of reperfusion were induced and the animals were sacrificed by exanguination. Group 4 (n=7): Anise+ CIR group, After administering 30 days of anise’s aqueous extract, CIR was induced and the study was terminated. TOS values of the Anise+ CIR group was significantly lower than that of the CIR group (p<0.05). Il-6 and TNF-α values of the CIR group were significantly higher than the Anise+CIR group (p<0,05). Our study revealed that anise ameliorates oxidative damage and inflammation due to cerebral ischemia/reperfusion, by reducing the levels of inflammatory cytokines (TNF-α, Il-6).

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2023
• Tom: 26
• Numer: 3
• Opis fizyczny: p.343-347,fig.,ref.

Twórcy

autor

Yildizhan E.

• Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Ozesmer H.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Inan M.M.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Tatli F.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Rencber M.

• Department of General Surgery, Viransehir State Hospital, 63700, Viransehir, Şanlıurfa, Turkey

autor

Akbas A.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Kamar M.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Gunduz E.

• Department of Emergency Medicine, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Baksi N.

• Department of Laboratuary Animals, Faculty of Veterinary, Dicle University, 21280, Diyarbakır, Turkey

autor

Ulger B.V.

• Department of General Surgery, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Akkus M.

• Department of Histology and Embryology, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

autor

Kaydu A.

• Department of Anesthesia, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

Identyfikatory

DOI

10.24425/pjvs.2023.145038