Metabotropic glutamate receptor ligands as a possible targets for treatment of anxiety and depression

• Autorzy: Pilc A. , Branski P. , Palucha-Poniewiera A. , Stachowicz K. , Wierunska J.
• Języki publikacji: EN

Abstrakty

EN

Preclinical data indicated that antagonists of group I mGlu receptors, particularly antagonists of mGlu5 receptors, produced both anxiolytic-like and antidepressant-like effects. Clinical data also demonstrated that mGlu5 receptor antagonist, fenobam, was an active anxiolytic drug. The anxiolytic effects exerted by mGlu5 receptor antagonists are profound, comparable to or stronger than those of benzodiazepines. Among all mGlu receptor ligands, group II mGlu receptor agonists seem to be drugs with promising therapeutic potential and good safety profi le. Animal studies showed anxiolytic-like effects of group II mGlu receptor agonists. Currently, group II mGlu receptor agonists are in phase III clinical trials for potential treatment of anxiety disorders. On the other hand, data have been accumulated indicating that antagonists of group II mGlu receptors have an antidepressant potential. Group III mGlu receptor ligands represent the least investigated group of mGlu receptors. The preclinical data, however, indicate that a selective agonist of mGlu4 and Glu8 receptors- ACPT-I produced anxiolytic but not antidepressant effects after peripheral administration, while the selective positive allosteric modulator of Glu7 receptors, AMN082 produced both anxiolytic and antidepressantlike. The data show that the effects of group III mGlu receptor ligands may differ dependently of their receptor subtype specifi city

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.288

Twórcy

autor

Pilc A.

• Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Branski P.

• Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Palucha-Poniewiera A.

• Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Stachowicz K.

• Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland

autor

Wierunska J.

• Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland