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2013 | 60 | 4 |
Tytuł artykułu

Studies on the formation of O/W nano-emulsions, by low-energy emulsification method, suitable for cosmeceutical applications

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
 The formation of oil/water (O/W) nano-emulsions suitable for cosmeceutical application was studied. Nano-emulsions were prepared by using phase inversion composition (PIC) method, one of the low-energy emulsification methods. The process consist of stepwise water addition to oil/surfactant mixture, at T = 25°C. Caprylic/capric triglycerides (GTCC), propylene glycol dicaprylate/dicaprate (PC) and oleic acid (OA) were applied as an oil phase. Polysorbate 80 was used as the surfactant. Kinetic stability of the nano-emulsions was analyzed by measuring droplet size as a function of time for different oil/surfactant ratio. The particles size distribution was analyzed by means DLS measurement technique (Dynamic Light Scattering), using Zetasizer Nano ZS (Malvern Instruments, UK). One of triterpenoic acid, practically non-water soluble substance was selected as an active and incorporated into the stable formulation. The obtained results proved that the nanoemulsion NE-T80-GTCC-20:80 based on caprylic/capric triglycerides with the oil/surfactant ratio O/S = 2 0:80 and the droplet size r = 25 nm was the most stable one and additionally showed the highest solubilisation capacity for the triterpene.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
60
Numer
4
Opis fizyczny
p.779-782,fig.,ref.
Twórcy
autor
  • Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Krakow, Poland
autor
  • Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Krakow, Poland
autor
  • Faculty of Environmental Engineering, Institute of Water Supply and Environmental Protection, Cracow University of Technology, Krakow, Poland
autor
  • Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Krakow, Poland
Bibliografia
  • Gao XH, Zhang L, Wei H, Chen HD (2008) Efficacy and safety of innovative cosmeceuticals. Clin Dermatol 26: 367-374. 
  • El Maghraby GM (2008) Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants. Int J Pharm 355: 285-292. 
  • Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A (2003) Microemulsions for topical delivery of estradiol. Int J Pharm 254: 99-107. 
  • Teo B, Basri M, Zakaria M, Salleh A, Rahman R, Rahman M (2010) A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals. J Nanobiotechnology 8: 4. 
  • Tadros T, Izquierdo P, Esquena J, Solans C (2004) Formation and stability of nano-emulsions. Adv Colloid Interface Sci 108-109: 303-318. 
  • Gursoy RN, Benita S (2004) Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 58: 173-182. 
  • Hong JY, Kim JK, Song YK, Park JS, Kim CK (2006) A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption. J Controlled Release 110: 332-338. 
  • Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, Kim DD, Jee JP, Lee YB, Woo JS, Yong CS, Choi HG (2009) Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm 374: 66-72. 
  • Rao S, Agarwal P, Shao J (2008) Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs. Int J Pharm 362: 10-15. 
  • Wang G, Tang W, Bidigare RR (2005) Terpenoids as Therapeutic Drugs and Pharmaceutical Agents in Natural Products: Drug Discovery and Therapeutic Medicine, pp 97-227. Humana Press Inc., Totowa, NJ. 
  • Silva M , David J, Silva L, Santos R, David J, Lima L, Reis P, Fontana R (2012) Bioactive oleanane, lupane and ursane triterpene acid derivatives. Molecules 17: 12197-12205. 
  • Sadurni N, Solans C, Azemar N, Garcia-Celma MJ (2005) Eur J Pharm Sci 26: 438-445. 
  • Kelmann R, Kuminek G, Teixeira H, Koester L (2007) Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process. Int J Pharm 342: 231-239. 
  • Yuan Y, Gao Y, Zhao J, Mao L (2008) Characterization and stability evaluation of b-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Res Int 41: 61-68.
  • Saberi Ah, Fang Y, McClements FD (2013) Fabrication of vitamin E-enriched nanoemulsions: Factors affecting particle size using spontaneous emulsification. J Colloid Interface Sci 391: 95-102. 
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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