Biochemical changes in the brain of rats with different resistance to hypoxia exposed to cadmium toxicity

• Autorzy: Labudda M.
• Języki publikacji: EN

Abstrakty

EN

Individual resistance to hypoxia is one of the cardinal features of the mammalian body. This resistance is closely related with different enzymatic activity system of metabolizing xenobiotics, in particular, the activity of cytochrome P450 and microsomal oxidation system of liver. Low and high resistance to hypoxia may be an important criterion in the individual approach to the pharmacotherapy of diseases associated with conditions of hypoxia, and can also be used to predict and prevent early and long-term complications of drug therapy. The goal of the study was to estimate the effect of cadmium (II) chloride intoxication, on the activity of some metabolic enzymes (alanine transaminase ALT, aspartate transaminase AST, lactate dehydrogenase LDH and succinate dehydrogenase SDH), and the levels of lipid and protein oxidation processes in the brain of male rats with different resistance to hypoxia. The results suggest that the activity of metabolic enzymes (AST, LDH, SDH) is higher in animals presenting low resistance to hypoxia in the control group, and thus can serve as a compensatory reserve mechanism under unfavorable environmental conditions. However, rats with high resistance to hypoxia display an increased tension of regulatory mechanisms and a decreased ability of antioxidant system, which results in the activation of lipid and protein oxidation precesses under cadmium intoxication. Conclude, the cadmium intoxication decreases the activity of ALT in rats with high resistance to hypoxia, whereas the activity of AST and LDH is higher in the brains of cadmium-exposed rats with low resistance to hypoxia.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 1
• Opis fizyczny: p.152

Twórcy

autor

Labudda M.

• Department of Animal Physiology, Institute of Biology and Environment Protection, Pomeranian University, Slupsk, Poland