Wpływ nienasyconych kwasów tłuszczowych n-3 i n-6 na metabolizm tkanki kostnej

• Autorzy: Grabos D. , Gawlowska A.

Warianty tytułu

EN

The effect of unsaturated fatty acids n-3 and n-6 on bone tissue metabolism

• Języki publikacji: PL

Abstrakty

PL

Kości są aktywną metabolicznie tkanką podlegającą trwającemu przez całe życie procesowi modelowania. Metabolizm kości kontrolują czynniki systemowe, jak również i lokalne, a znaczącą rolę ogrywa także odpowiednio zbilansowana dieta. Wielo- nienasycone kwasy tłuszczowe (WKT) budzą zainteresowanie jako naturalne substancje, które mogą oddziaływać na komórki tkanki kostnej modyfikując ich metabolizm. Są one prekursorami eikozanoidów, które uczestniczą w wielu mechanizmach regulacyjnych. Przy udziale COX powstają prostaglandyny, prostacykliny i tromboksany, natomiast pod wpły­wem LOX leukotrieny. Z kwasu arachidonowego (AA) pod wpływem COX powstaje m.in. PGE2, która pośredni­czy w oddziaływaniu na tkankę kostną hormonów kalcytropowych, cytokin proresorbcyj- nych i czynników wzrostu. Prawidłowa suplementacja ogranicza działanie AA, czego skut­kiem jest obniżenie poziomu PGE2, a tym samym osłabienie intensywności zmian zaniko­wych tkanki kostnej. W świetle przeprowadzonych badań dotyczących leczenia, a przede wszystkim profilaktyki, suplementacja diety WKT odgrywa znaczącą rolę w metabolizmie tkanki kostnej zwierząt i ludzi.

EN

Bones are metabolically active tissues, which undergo a lifelong process of mod­eling. Bone metabolism is controlled by system factors as well as by local ones, besides balanced diet plays a significant role. Polyunsaturated fatty acids (PUFA) raise an interest as natural substances that can affect bone cells and modify their metabolism. They are the precursors of eicosanoids which are involved in a number of regulatory mechanisms, among others, at the level of bone tissue. With the participation of COX there appear pros­taglandins, prostacyclins and monoenes thromboxanes, while under the influence of LOX leukotrienes. From arachidonic acid (AA) under the influence of COX is formed PGE2, which in turn mediates in the impact on calciotropic hormones bone tissue, proresorptive cytokines and growth factors. Adequate supplementation reduces the activity of AA result­ing in a diminution of PGE2 level, thereby weakening the intensity of atrophic changes in bone tissue. In the light of conducted research on the treatment and in particular on the prevention, PUFA diet supplementation plays a significant role in the metabolism of both animal and human bone tissue.

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Medicina Veterinaria
• Rocznik: 2011
• Tom: 10
• Numer: 4
• Opis fizyczny: s.23-34,tab.,bibliogr.

Twórcy

autor

Grabos D.

• Uniwersytet Przyrodniczy w Lublinie, Lublin

autor

Gawlowska A.

• Uniwersytet Przyrodniczy w Lublinie, Lublin

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