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2012 | 59 | 1 |

Tytuł artykułu

Carotenoid composition and in vitro pharmacological activity of rose hips

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the present study was to compare carotenoid extracts of Rose hips (Rosa canina L.) with regard to their phytochemical profiles and their in vitro anti-Helicobacter pylori (H. pylori), cytotoxic, multidrug resistance (MDR) reversal and radical scavenging activity. Carotenoid composition was investigated in the different fractionation of rose hips, using extraction methods. Six main carotenoids - epimers of neochrome, lutein, zeaxanthin, rubixanthin, lycopene, β,β-carotene - were identified from Rose hips by their chromatographic behavior and UV-visible spectra, which is in accordance with other studies on carotenoids in this plant material. The active principles in the carotenoid extract might differ, depending upon the extraction procedures.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

59

Numer

1

Opis fizyczny

p.129-132,ref.

Twórcy

autor
  • Department of Pharmacognosy, University of Pecs, Medical School, Pecs, Hungary
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Bibliografia

  • Britton G, Liaaen-Jensen S, Pfander H (2005) Carotenoids Today and Challenges for the Future. In Carotenoids Vol. 1A: Isolation and Analysis, Britton G, Liaaen-Jensen S, Pfander H, eds, pp 13-26 Birkhäuser Verlag, Basel, Boston, Berlin.
  • Deli J, Molnár P, Ősz E, Tóth G (2000) Analysis of Carotenoids in the Fruits of Asparagus falcatus: Isolation of 5,6-Diepikarpoxanthin. Chromatographia Suppl. 51: 183-187.
  • Garewal HS (1993) Potential role of beta-carotene and antioxidant vitamins in the prevention of oral cancer. Ann NY Acad Sci 669: 260-268. 
  • Kawase M, Motohashi N (2003) New multidrug resistance reversal agents. Curr Drug Targets 4: 31-33. 
  • Kawase M, Motohashi N (2004) Plant-derived leading compounds for eradication of Helicobacter pylori. Current Med Chem-Anti-Infective Agents 3: 89-100.
  • Kessel D (1989) Exploring multidrug resistance using rhodamine 123. Cancer Commun 1: 145-149. 
  • Krinsky N, Johnson E (2005) Carotenoid actions and their relation to health and disease. Mol Aspects Med 26: 459-516.  
  • Maoka T, Mochida K, Kozuka M et al. (2001) Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Lett 172: 103-109. 
  • Molnár J, Mucsi I, Molnár A, Gyémánt N, Szabó M, Varga A, Molnár P, Tóth G (2004) Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In vivo 18: 237-244. 
  • Molnár J, Engi H, Hohmann J, Molnár P, Deli J, Wesolowska O, Michalak K, Wang Q (2010) Reversal of multidrug resistance by natural substances from plants. Curr Top Med Chem 10: 1757-1768. 
  • Molnár P, Deli J, Matus Z, Tóth G (2001) A csipkebogyóban kis mennyiségben előforduló karotinoidok izolálása. J Hung Pharm Soc 45(3): 146.
  • Molnár P, Kawase M, Motohashi N (2005a) Isolation, crystallization and handling of carotenoids and the (E/Z)-isomerization of carotenoids. In Functional Polyphenols and Carotenoids with Antioxidative Action, Motohashi N, ed, pp. 111-133, Research Signpost, Kerala, India.
  • Molnár P, Kawase M, Satoh K, Sohara Y, Tanaka T, Tani S, Sakagami H, Nakashima H, Motohashi N, Gyémánt N, Molnár J (2005b) Biological Activity of Carotenoids of Red Paprika, Valencia Orange and Golden Delicious Apple. Phytother Res 19: 700-707. 
  • Motohashi N, Wakabayashi H, Kurihara T, Takada Y, Maruyama S, Sakagami H et al: (2003) Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper. Phytother Res 17: 348-352.  
  • Sakagami H, Jiang Y, Kusama K, Atsumi T, Ueha T, Toguchi M, Iwakura I, Satoh K, Ito H, Hatano T, Yoshida T (2000) Cytotoxic activity of hydrolyzable tannins against human oral tumor cell lines - a possible mechanism. Phytomedicine 7: 39-47. 
  • Sies H, Stahl W, Sundquist AR (1993) Antioxidant functions of vitamins E and C, beta-carotene and other carotenoids. Ann NY Acad Sci 669: 7-20. 
  • Silvaas A, Sakhi AK, Andersen LF et al. (2004) Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 134: 562-567. 
  • Weaver JL, Szabó G, Pine PS, Gottesman MM, Goldenberg S, Aszalós A (1993) The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. Int J Cancer 54: 456-461.

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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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