Pexophagy in penicillin G secretion by Penicillium chrysogenum PQ-96

• Autorzy: Kurzatkowski W. , Gebska-Kuczerowska A.
• Języki publikacji: EN

Abstrakty

EN

Penicillin G oversecretion by Penicillium chrysogenum PQ96 is associated with a strictly adjusted cellular organization of the mature and senescent mycelial cells. Abundant vacuolar phagy and extended cellular vacuolization combined with vacuolar budding resulting in the formation of vacuolar vesicles that fuse with the cell membrane are the most important characteristic features of those cells. We suggest as follows: if the peroxisomes are integrated into vacuoles, the penicillin G formed in peroxisomes might be transferred to vacuoles and later secreted out of the cells by an exocytosis process. The peroxisomal cells of the mycelium are privileged in penicillin G secretion.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2016
• Tom: 65
• Numer: 3
• Opis fizyczny: p.365-368,fig.,ref.

Twórcy

autor

Kurzatkowski W.

• Independent Laboratory of Streptomycetes and Fungi Imperfecti, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland

autor

Gebska-Kuczerowska A.

• Department of Health Promotion and Postgraduate Education, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland

Bibliografia

• Bartoszewska M., Ł. Opaliński, M. Veenhuis and I.J. van der Klei.2011. The significance of peroxisomes in secondary metabolite biosynthesis in filamentous fungi. Biotechnol. Lett. 33: 1921–1931.
• Garcίa-Estrada C., I. Vaca, M. Lamas-Maceiras and J.F. Martίn. 2007. In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum. Appl. Microbiol. Biotechnol. 76: 169–183.
• Kurzątkowski W., M. Staniszewska, M. Bondaryk and A. Gębska-Kuczerowska. 2014a. Compartmentalization in penicillin G biosynthesis by Penicillium chrysogenum PQ96. Polish J. Microbiol.63: 399–408.
• Kurzątkowski W., M. Staniszewska, M. Bondaryk and A. Gębska-Kuczerowska. 2014b. Penicillin G production by industrial strains of Penicillium chrysogenum. Post. Microbiol. 53: 366–370.
• Kurzątkowski W. and A. Gębska-Kuczerowska. 2015. Compartmentalization in cephalosporin biosynthesis by industrial strains of Acremonium chrysogenum. Post. Microbiol. 54: 374–379.
• Martίn J-F., R.V. Ullán and C. Garcia-Estrada. 2010. Regulation and compartmentalization of βlactam biosynthesis. Microbial. Biotechnol. 3: 285–299.
• Meijer W.H., L. Gidijala, S. Fekken, J.A Kiel, M.A. van den Berg, R. Lascaris, R.A. Bovenberg and I.J. van der Klei. 2010. Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum. Appl. Environ. Microbiol. 76: 5702–5709.
• Sakai Y., M. Oku, I.J. van der Klei and J.A Kiel. 2006. Pexophagy: autophagic degradation of peroxisomes. Biochim. Biophys. Acta1763: 1767–1775.
• Weber S.S., R.A. Bovenberg and A.J. Driessen. 2012. Biosynthetic concepts for the production of βlactam antibiotics in Penicillium chrysogenum. Biotechnol J. 7: 225–236.

Identyfikatory

DOI

10.5604/17331331.1215616