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2015 | 59 | 1 |
Tytuł artykułu

Effects of intrathecal administration of ketamine HCI in young calves: a clinical trial

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The purpose of the study was to investigate the clinical, biochemical, and cardiovascular effects of intrathecal (IT) administration of ketamine HCl in calves. The study was performed on seven Simmental and three Montofon calves, 1.70± 1.16 weeks old, weighing approximately 37 kg, undergoing surgical procedures including femur fracture repair (one case), atresia anus (five cases), prolapsed rectum (one case), suturing on rear limbs (two cases), and urethrostomy (one case). After administering IT ketamine HCl at a dose of 3 mg/kg to all calves, the level and depth of the anaesthesia was checked with a pinprick test. Each animal was monitored by recording heart rate, arterial blood pressure, respiratory rates, and rectal temperature. Furthermore, certain biochemical parameters, blood gases, oxygen-total haemoglobin, and electrolyte levels were measured. All data were statistically evaluated using Minitab 16 software. Anaesthesia occurred in all calves at an average of 5.00 ± 1.41 min (range: 3-7) and continued for an average of 61.4 ± 40 min (range: 55-70). Sufficient anaesthesia was achieved in all animals for the required operations, and no complications occurred with regard to clinical and haemodynamic measurements. We concluded that in calves, which are not deemed suitable for administration of local anaesthetic via IT due to certain side effects, sufficient anaesthesia can be provided with ketamine by the same method for operations performed in the perineal area and hind extremities, and that this could be a good alternative for anaesthesia under field conditions.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
59
Numer
1
Opis fizyczny
p.155-159,ref.
Twórcy
autor
  • Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36300 Kars, Turkey
autor
  • Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36300 Kars, Turkey
autor
  • Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36300 Kars, Turkey
autor
  • Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36300 Kars, Turkey
autor
  • Department of Biochemistry Faculty of Veterinary Medicine, Kafkas University, 36300 Kars, Turkey
Bibliografia
  • 1. Acosta A.D, Gomar C., Correa-Natalini C., Bopp S., Polydoro A., Sala-Blanch X.: Analgesic effects of epidurally administered levogxral ketamine alone or in combination with morphine on intraoperative and postoperative pain in dogs undergoing ovariohysterectomy. Am J Vet Res 2005, 66, 54-61.
  • 2. Aksoy O., Ozaydin I., Kirmizigul A.H., Kilic E., Ozturk S., Kurt B., Yayla S., Sozmen M., Atakisi E.: Evaluation of experimental subarachnoid analgesia with a combination of detomidine and ropivacaine for flank analgesia in cows. Vet Arhiv 2012, 82, 463-472.
  • 3. Blue J.T., Short C.E.: Preanesthetic evaluation and clinical pathology. In: Principles and Practice of Veterinary Anesthesia, edited by Shot C.E.. Williams & Wilkins, Baltimore, 1987, pp. 3-7.
  • 4. De Rossi R., Almeida R.G., Medeiros U., Righetto F.R., Frazilio F.O.: Subarachnoid butorphanol augments lidocaine sensory anaesthesia in calves. Vet J 2007, 173, 658-663.
  • 5. El-Shobary H.M., Sonbul Z.M., Schricker T.P.: Epidural ketamine for postoperative analgesia in the elderly. M E J Anesth 2008, 19, 1369-1378.
  • 6. Fridericia L.S.: Die systolendauer im electrocardiogramm bei normalen menchen und bei herzkranken. Acta Med Scand 1920, 53, 469-486.
  • 7. Govindan K., Krishnani R., Kaufman M.P., Michael R., Fogler R.J., Gintautus J.: Intrathecal ketamine in surgeries for lower abdomen and lower extremities. Proc Pharmacol Soc 2001, 44, 197-199.
  • 8. Hodgson P.S., Neal J.M., Pollock J.E., Liu S.S.: The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 1999, 88, 797-809.
  • 9. Iida H., Dohi S., Tanahashi T., Watanabe Y., Takenaka M.: Spinal conduction block by intrathecal ketamine in dogs. Anesth Analg 1997, 85, 106-110.
  • 10. Kamiloglu A., Atalan G., Ozturk S., Kilic E.: Epidural injection of ketamine hydrochloride for perineal analgesia in cattle. Ir Vet J 2003, 56, 514-516.
  • 11. Koc Y., Kul M., Alkan F., Ogurtan Z.: The effects of midazolam-ketamine and xylazine-ketamine on arterial blood pressure and blood gases in dogs. Eurasian J Vet Sci 2002 18, 57-62.
  • 12. Kohrs R., Durieux M.E.: Ketamine: teaching an old drug new tricks. Anesth Analg 1998, 87, 1186-1193.
  • 13. Lee I.O., Lee I.H., Lee K.C.: Pre-versus post-formalin effects of intrathecal ketamine on spinal fos-like immunoreactivity in rats. Indian J Med Res 2004, 120, 527-533.
  • 14. Lee I., Yoshiuchi T., Yamagishi N., Oboshi K., Ayukawa Y., Sasaki N., Yamada H.: Analgesic effect of caudal epidural ketamine in cattle. J Vet Sei 2003, 4, 261-264.
  • 15. Lizarraga I., Chambers J.P., Johnson C.B.: Prevention of N-methyl-d-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep. Anesth Analg 2008, 107, 2061-2067.
  • 16. Reich D.L., Silvay G.: Ketamine: an update on the first twenty - five years of clinical experience. Can J Anaesth 1989, 36, 186-197.
  • 17. Samantaray A., Rao M.H.: Evaluation of midazolam as an additive to intrathecal ketamine: J Anaesth Clin Pharmacol 2006, 22, 363-369.
  • 18. Schuszler L., Igna C., Sala A., Brudiu I., Sabau M., Dascalu R.: Intraoperative analgesic effect of butarphanol for ovariohysterectomty in bitches: a dose titration study. L $ M V 2009, 2, 160-163.
  • 19. Vranken J.H., Troost D., Haan P., Pennings F.A., Van Der Vegt M.H., Dijkgraaf M.G.V., Hollmann M.W.: Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservative-free s(+)-ketamine. Anesthesiology 2006, 105, 813-818.
  • 20. Yayla S., E Kilic.: The comparison of clinical, histopathological and some hemodynamic effect of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Univ Vet Fak Derg 2010, 16, 835-840.
  • 21. Yayla S., Kilic E., Aksoy O., Ozaydin I., Ogun M., Steagall P.V.M.: The effects of subarachnoid administration of hyperbaric solutions of bupivacaine or ropivacaine in xylazine- sedated calves undergoing surgery. Vet Ree 2013, 173, 580.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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